Effect of transfusion on immune function in a traumatized animal model.

Blood transfusions repeatedly have been shown to prolong allograft survival, probably by stimulating suppressor T lymphocytes. The effects of transfusions on immune function in traumatized patients has not previously been investigated. We investigated the effects of transfusions on the immune system using a burned rat model. The transfusions were found to have no effect on the white blood cell counts, differential cell count, or neutrophil migration and bactericidal index. Those animals that received transfusion did exhibit impaired cell-mediated immunity and macrophage migration. Blood transfusions seem to increase further the immunosuppression seen with trauma and surgery.

[1]  J. Gitlin,et al.  Diminished helper/suppressor lymphocyte ratios and natural killer activity in recipients of repeated blood transfusions. , 1984, Blood.

[2]  N. Zoumbos,et al.  Immunologic abnormalities in patients receiving multiple blood transfusions. , 1984, Annals of internal medicine.

[3]  B. Rabin,et al.  Decreased helper/suppressor cell ratios after treatment with factor VIII and IX concentrates and fresh frozen plasma. , 1984, The American journal of medicine.

[4]  J. Thomas,et al.  Long-term incompatible kidney survival in outbred higher primates without chronic immunosuppression. , 1983, Annals of surgery.

[5]  G. Reaman,et al.  ALTERED DISTRIBUTION OF T-LYMPHOCYTE SUBPOPULATIONS IN CHILDREN AND ADOLESCENTS WITH HAEMOPHILIA , 1983, The Lancet.

[6]  J. Hansbrough,et al.  Postburn immunosuppression in an animal model: monocyte dysfunction induced by burned tissue. , 1983, Surgery.

[7]  M. Lederman,et al.  Impaired cell-mediated immunity in patients with classic hemophilia. , 1983, The New England journal of medicine.

[8]  R. Aster,et al.  T-lymphocyte subpopulations in patients with classic hemophilia treated with cryoprecipitate and lyophilized concentrates. , 1983, The New England journal of medicine.

[9]  P. Tartter,et al.  EFFECT OF BLOOD TRANSFUSIONS ON COLONIC MALIGNANCY RECURRENCE RATE , 1982, The Lancet.

[10]  D. Francis,et al.  BLOOD TRANSFUSION AND TUMOUR GROWTH: EVIDENCE FROM LABORATORY ANIMALS , 1981, The Lancet.

[11]  R. Stoney,et al.  Deliberate Donor‐specific Blood Transfusions Prior to Living Related Renal Transplantation: A New Approach , 1980, Annals of surgery.

[12]  A. Kluge,et al.  Blood transfusion-induced suppression of cellular immunity in man. , 1980, Human immunology.

[13]  J. Briggs,et al.  ENDOGENOUS CELL-MEDIATED IMMUNITY, BLOOD TRANSFUSION, AND OUTCOME OF RENAL TRANSPLANTATION , 1979, The Lancet.

[14]  J. Turinsky,et al.  Macrophage Dysfunction After Burn Injury , 1979, Infection and immunity.

[15]  J. Meakins,et al.  Delayed hypersensitivity and neutrophil chemotaxis: effect of trauma. , 1978, The Journal of trauma.

[16]  J. Meakins,et al.  Host Resistance in Sepsis and Trauma , 1975, Annals of surgery.

[17]  R. Simmons,et al.  Immunodepression after major surgery in normal patients. , 1975, Surgery.

[18]  Alexander Jw,et al.  Improved tests for the evaluation of neutrophil function in human disease. , 1968 .