This information is current as Responses Adenosine A 2 A Receptor-Mediated Human Inflammatory Joint Disease Involves NURR 1 Expression by Methotrexate in Modulation of Orphan Nuclear Receptor

[1]  A. Wunder,et al.  Methotrexate (MTX) and albumin coupled with MTX (MTX-HSA) suppress synovial fibroblast invasion and cartilage degradation in vivo , 2004, Annals of the rheumatic diseases.

[2]  J. Kremer.  Toward a better understanding of methotrexate. , 2004, Arthritis and rheumatism.

[3]  B. Bresnihan,et al.  Cyclooxygenase 2-derived prostaglandin E2 production by corticotropin-releasing hormone contributes to the activated cAMP response element binding protein content in rheumatoid arthritis synovial tissue. , 2004, Arthritis and rheumatism.

[4]  Keesook Lee,et al.  Molecular Mechanism of Suppression of Testicular Steroidogenesis by Proinflammatory Cytokine Tumor Necrosis Factor Alpha , 2004, Molecular and Cellular Biology.

[5]  F. Amalric,et al.  Endothelial cell phenotypes in the rheumatoid synovium: activated, angiogenic, apoptotic and leaky , 2004, Arthritis research & therapy.

[6]  B. Ludewig,et al.  CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2. , 2004, Blood.

[7]  M. Dawson,et al.  Mitogenic Effect of Orphan Receptor TR3 and Its Regulation by MEKK1 in Lung Cancer Cells , 2003, Molecular and Cellular Biology.

[8]  R. Hughes,et al.  Folate supplementation and methotrexate treatment in rheumatoid arthritis: a review. , 2003, Rheumatology.

[9]  I. Zachary,et al.  Vascular Endothelial Growth Factor–Regulated Gene Expression in Endothelial Cells: KDR-Mediated Induction of Egr3 and the Related Nuclear Receptors Nur77, Nurr1, and Nor1 , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[10]  I. Goldman,et al.  Resistance to antifolates , 2003, Oncogene.

[11]  P. Ordentlich,et al.  Identification of the Antineoplastic Agent 6-Mercaptopurine as an Activator of the Orphan Nuclear Hormone Receptor Nurr1* , 2003, Journal of Biological Chemistry.

[12]  T. Mak,et al.  Nur77 as a survival factor in tumor necrosis factor signaling , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[13]  B. Bresnihan,et al.  Increased perivascular synovial membrane expression of myeloid-related proteins in psoriatic arthritis. , 2003, Arthritis and rheumatism.

[14]  M. Sitkovsky,et al.  Targeting G protein-coupled A2a adenosine receptors to engineer inflammation in vivo. , 2003, The international journal of biochemistry & cell biology.

[15]  D. Ettinger,et al.  Novel antifolate drugs , 2003, Current oncology reports.

[16]  L. Badimón,et al.  Neuron-Derived Orphan Receptor-1 (NOR-1) Modulates Vascular Smooth Muscle Cell Proliferation , 2003, Circulation research.

[17]  M. Cutolo,et al.  Methotrexate in psoriatic arthritis. , 2002, Clinical and experimental rheumatology.

[18]  V. de Waard,et al.  Protective Function of Transcription Factor TR3 Orphan Receptor in Atherogenesis: Decreased Lesion Formation in Carotid Artery Ligation Model in TR3 Transgenic Mice , 2002, Circulation.

[19]  B. Bresnihan,et al.  Corticotropin‐Releasing Hormone Signaling in Synovial Tissue Vascular Endothelium Is Mediated through the cAMP/CREB Pathway , 2002, Annals of the New York Academy of Sciences.

[20]  M. Cutolo,et al.  Antiproliferative‐Antiinflammatory Effects of Methotrexate and Sex Hormones on Cultured Differentiating Myeloid Monocytic Cells (THP‐1) , 2002, Annals of the New York Academy of Sciences.

[21]  B. Cronstein,et al.  Molecular action of methotrexate in inflammatory diseases , 2002, Arthritis research.

[22]  B. Bresnihan,et al.  Activation of Nuclear Orphan Receptor NURR1 Transcription by NF-κB and Cyclic Adenosine 5′-Monophosphate Response Element-Binding Protein in Rheumatoid Arthritis Synovial Tissue1 , 2002, The Journal of Immunology.

[23]  S. Weitzman,et al.  Chronic inflammation and cancer. , 2002, Oncology.

[24]  A. Ohta,et al.  Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage , 2001, Nature.

[25]  B. Aggarwal,et al.  Methotrexate Suppresses NF-κB Activation Through Inhibition of IκBα Phosphorylation and Degradation1 , 2001, The Journal of Immunology.

[26]  J. Mcpherson,et al.  Adenosine A2A Receptor Stimulation Reduces Inflammation and Neointimal Growth in a Murine Carotid Ligation Model , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[27]  B. Bresnihan,et al.  Involvement of the nuclear orphan receptor NURR1 in the regulation of corticotropin-releasing hormone expression and actions in human inflammatory arthritis. , 2001, Arthritis and rheumatism.

[28]  G. Panayi,et al.  Cytokine pathways and joint inflammation in rheumatoid arthritis. , 2001, The New England journal of medicine.

[29]  S. Tetradis,et al.  Printed in U.S.A. Copyright © 2001 by The Endocrine Society Parathyroid Hormone Induces Expression of the Nuclear Orphan Receptor Nurr1 in Bone Cells* , 2000 .

[30]  B. Bresnihan,et al.  The pathogenesis and prevention of joint damage in rheumatoid arthritis: advances from synovial biopsy and tissue analysis. , 2000, Arthritis and rheumatism.

[31]  A. Sulli,et al.  Antiproliferative and antiinflammatory effects of methotrexate on cultured differentiating myeloid monocytic cells (THP-1) but not on synovial macrophages from patients with rheumatoid arthritis. , 2000, The Journal of rheumatology.

[32]  G. Greenberg,et al.  A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease. North American Crohn's Study Group Investigators. , 2000, The New England journal of medicine.

[33]  C. Faltynek,et al.  Effects of methotrexate on nucleotide pools in normal human T cells and the CEM T cell line. , 2000, Life sciences.

[34]  B. Cronstein,et al.  Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant arthritis. , 2000, Arthritis and rheumatism.

[35]  Beverly H. Koller,et al.  Disruption of the A3 Adenosine Receptor Gene in Mice and Its Effect on Stimulated Inflammatory Cells* , 2000, The Journal of Biological Chemistry.

[36]  G. Chrousos,et al.  Ligand-Activation of the Adenosine A2a Receptors Inhibits IL-12 Production by Human Monocytes , 2000, The Journal of Immunology.

[37]  Bright Rd.  Methotrexate in the treatment of psoriasis. , 1999, The Medical letter on drugs and therapeutics.

[38]  V. Giguère,et al.  Orphan nuclear receptors: from gene to function. , 1999 .

[39]  E. Snyder,et al.  Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes , 1999, Nature Biotechnology.

[40]  P. Loetscher,et al.  Effects of methotrexate on differentiation of monocytes and production of cytokine inhibitors by monocytes. , 1998, Arthritis and rheumatism.

[41]  F. Breedveld,et al.  Microscopic measurement of cellular infiltration in the rheumatoid arthritis synovial membrane: a comparison of semiquantitative and quantitative analysis. , 1998, British journal of rheumatology.

[42]  B. Dijkmans,et al.  Methotrexate reduces inflammatory cell numbers, expression of monokines and of adhesion molecules in synovial tissue of patients with rheumatoid arthritis. , 1998, British journal of rheumatology.

[43]  F. Breedveld,et al.  Quantitative microscopic analysis of inflammation in rheumatoid arthritis synovial membrane samples selected at arthroscopy compared with samples obtained blindly by needle biopsy. , 1998, Arthritis and rheumatism.

[44]  M. Weinblatt,et al.  Longterm prospective study of methotrexate in rheumatoid arthritis: conclusion after 132 months of therapy. , 1998, The Journal of rheumatology.

[45]  D. Furst.  The rational use of methotrexate in rheumatoid arthritis and other rheumatic diseases. , 1997, British journal of rheumatology.

[46]  B J Hoffer,et al.  Dopamine neuron agenesis in Nurr1-deficient mice. , 1997, Science.

[47]  W. Gerald,et al.  Molecular analysis of the fusion of EWS to an orphan nuclear receptor gene in extraskeletal myxoid chondrosarcoma. , 1997, The American journal of pathology.

[48]  B. Cronstein.  Molecular therapeutics. Methotrexate and its mechanism of action. , 1996, Arthritis and rheumatism.

[49]  E. Vizi,et al.  Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. , 1996, Journal of immunology.

[50]  J. Fay,et al.  FK506 in combination with methotrexate for the prevention of graft-versus-host disease after marrow transplantation from matched unrelated donors. , 1996, Blood.

[51]  G. Firestein,et al.  Inhibition of synoviocyte collagenase gene expression by adenosine receptor stimulation. , 1996, Arthritis and rheumatism.

[52]  G. Firestein,et al.  Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptors. , 1996, Journal of immunology.

[53]  G. Wahl,et al.  A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. , 1996, Genes & development.

[54]  K. Umesono,et al.  The nuclear receptor superfamily: The second decade , 1995, Cell.

[55]  L. Crofford,et al.  Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin‐1: a potential mechanism for inflammatory angiogenesis , 1995, FEBS letters.

[56]  D. Gladman,et al.  Longterm methotrexate therapy in psoriatic arthritis: clinical and radiological outcome. , 1995, The Journal of rheumatology.

[57]  N. Ohkura,et al.  Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells. , 1994, Biochemical and biophysical research communications.

[58]  R. Bravo,et al.  NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3. , 1994, Molecular endocrinology.

[59]  J. V. D. van der Meer,et al.  Circulating concentrations and production of cytokines and soluble receptors in rheumatoid arthritis patients: effects of a single dose methotrexate. , 1994, British journal of rheumatology.

[60]  D. Veale,et al.  Classification of clinical subsets in psoriatic arthritis. , 1994, British journal of rheumatology.

[61]  B. Calnan,et al.  Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas , 1994, Nature.

[62]  B. Cronstein,et al.  The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation. , 1993, The Journal of clinical investigation.

[63]  R Taub,et al.  RNR-1, a nuclear receptor in the NGFI-B/Nur77 family that is rapidly induced in regenerating liver. , 1993, The Journal of biological chemistry.

[64]  B. O’Malley,et al.  Identification of a new brain-specific transcription factor, NURR1. , 1992, Molecular endocrinology.

[65]  D. Schrier,et al.  The effects of (R)-N-(1-methyl-2-phenylethyl) adenosine (L-PIA), a standard A1-selective adenosine agonist on rat acute models of inflammation and neutrophil function , 1991, Agents and Actions.

[66]  M. Johnston,et al.  Identification of the DNA binding site for NGFI-B by genetic selection in yeast. , 1991, Science.

[67]  B. Cronstein,et al.  Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[68]  M. A. van 't Hof,et al.  Judging disease activity in clinical practice in rheumatoid arthritis: first step in the development of a disease activity score. , 1990, Annals of the rheumatic diseases.

[69]  R. Gilbertsen,et al.  The antiinflammatory effects of adenosine receptor agonists on the carrageenan-induced pleural inflammatory response in rats. , 1990, Journal of immunology.

[70]  L. Lau,et al.  A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[71]  Z. Werb,et al.  Commitment to expression of the metalloendopeptidases, collagenase and stromelysin: relationship of inducing events to changes in cytoskeletal architecture , 1986, The Journal of cell biology.

[72]  W. Buchanan,et al.  Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. , 1968, The Quarterly journal of medicine.

[73]  J. Wolff,et al.  Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid. , 1948, The New England journal of medicine.

[74]  H. Eibel,et al.  Characterization of SV40 T antigen immortalized human synovial fibroblasts: maintained expression patterns of EGR-i, HLA-DR and some surface receptors , 2005, Rheumatology International.

[75]  B. Cronstein,et al.  Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68. , 2003, Arthritis and rheumatism.

[76]  J. Jankovic,et al.  Mutations in NR4A2 associated with familial Parkinson disease , 2003, Nature Genetics.

[77]  A. Koch.  Review: angiogenesis: implications for rheumatoid arthritis. , 1998, Arthritis and rheumatism.

[78]  O. Conneely,et al.  Neuroendocrine regulation of the hypothalamic pituitary adrenal axis by the nurr1/nur77 subfamily of nuclear receptors. , 1997, Molecular endocrinology.

[79]  B. Cronstein,et al.  Adenosine A1 receptor promotion of multinucleated giant cell formation by human monocytes: a mechanism for methotrexate-induced nodulosis in rheumatoid arthritis. , 1997, Arthritis and rheumatism.

[80]  O. Conneely,et al.  Differential regulation of transcription by the NURR1/NUR77 subfamily of nuclear transcription factors. , 1996, Gene expression.

[81]  B. Cronstein.  Adenosine, an endogenous anti-inflammatory agent. , 1994, Journal of applied physiology.

[82]  R. Wolf,et al.  Leukocyte adherence in rat mesenteric venules: effects of adenosine and methotrexate. , 1993, Gastroenterology.