Surface modification with PEG and hirudin for protein resistance and thrombin neutralization in blood contact.

[1]  Liang Wang,et al.  Surfaces having dual fibrinolytic and protein resistant properties by immobilization of lysine on polyurethane through a PEG spacer. , 2009, Journal of biomedical materials research. Part A.

[2]  F. Leermakers,et al.  Why surfaces modified by flexible polymers often have a finite contact angle for good solvents. , 2006, Langmuir : the ACS journal of surfaces and colloids.

[3]  Maria Cristina Tanzi,et al.  Bioactive technologies for hemocompatibility , 2005, Expert review of medical devices.

[4]  M. Brook,et al.  Protein repellant silicone surfaces by covalent immobilization of poly(ethylene oxide). , 2005, Biomaterials.

[5]  Heather Sheardown,et al.  Chemisorption of thiolated poly(ethylene oxide) to gold: surface chain densities measured by ellipsometry and neutron reflectometry. , 2005, Journal of colloid and interface science.

[6]  Buddy D Ratner,et al.  Biomaterials: where we have been and where we are going. , 2004, Annual review of biomedical engineering.

[7]  S. vandeVondele,et al.  Peptide functionalized poly(L-lysine)-g-poly(ethylene glycol) on titanium: resistance to protein adsorption in full heparinized human blood plasma. , 2003, Biomaterials.

[8]  J. Brash,et al.  Synthesis and characterization of thiol‐terminated poly(ethylene oxide) for chemisorption to gold surface , 2003 .

[9]  A. B. Anderson,et al.  Interactions of fibrinolytic system proteins with lysine-containing surfaces. , 2003, Journal of biomedical materials research. Part A.

[10]  M. Horne,et al.  Antithrombin activity of lepirudin adsorbed to silicone (polydimethylsiloxane) tubing. , 2003, Thrombosis research.

[11]  G. Colombo,et al.  Probing the hirudin-thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation. , 2002, Biochemistry.

[12]  M. Grunze,et al.  Grafting of Alkanethiol-Terminated Poly(ethylene glycol) on Gold , 2002 .

[13]  J. Brash,et al.  Identification of apolipoprotein A-I as a major adsorbate on biomaterial surfaces after blood or plasma contact. , 2002, Biomaterials.

[14]  D. Klee,et al.  Universal Approach Towards r‐Hirudin Derivatives with High Anti‐Thrombin Activity Based on Chemical Differentiation of Primary Amino Groups , 2002 .

[15]  Buddy D. Ratner,et al.  PEO-like plasma polymerized tetraglyme surface interactions with leukocytes and proteins: in vitro and in vivo studies , 2002, Journal of biomaterials science. Polymer edition.

[16]  J. Brash,et al.  Protein adsorption to polyethylene glycol modified liposomes from fibrinogen solution and from plasma. , 2001, Biochimica et biophysica acta.

[17]  J. Lahann,et al.  Bioactive immobilization of r-hirudin on CVD-coated metallic implant devices. , 2001, Biomaterials.

[18]  E. Aydil,et al.  Polyethylene glycol-coated biocompatible surfaces. , 2000, Journal of biomedical materials research.

[19]  David A. Russell,et al.  Self-assembled monolayers: a versatile tool for the formulation of bio-surfaces , 2000 .

[20]  J. Brash,et al.  Adsorption of plasminogen from human plasma to lysine-containing surfaces. , 2000, Journal of biomedical materials research.

[21]  J. Brash.  Exploiting the current paradigm of blood–material interactions for the rational design of blood-compatible materials , 2000, Journal of biomaterials science. Polymer edition.

[22]  J. Brash,et al.  Measurement of protein adsorption to gold surface by radioiodination methods: suppression of free iodide sorption , 2000 .

[23]  P. Tengvall,et al.  Peptide modified gold-coated polyurethanes as thrombin scavenging surfaces. , 2000, Journal of biomedical materials research.

[24]  J. Brash,et al.  Modification of liposomes with N-substituted polyacrylamides: identification of proteins adsorbed from plasma. , 1999, Biochimica et biophysica acta.

[25]  I. Kang,et al.  Synthesis and characterization of heparinized polyurethanes using plasma glow discharge. , 1999, Biomaterials.

[26]  D. J. Dempsey,et al.  Covalent linkage of recombinant hirudin to a novel ionic poly(carbonate) urethane polymer with protein binding sites: determination of surface antithrombin activity. , 1998, Artificial organs.

[27]  H. Sheardown,et al.  MEASUREMENT OF PROTEIN ADSORPTION TO METALS USING RADIOIODINATION METHODS : A CAVEAT , 1997 .

[28]  P. Romaniuk,et al.  Covalent immobilization of hirudin improves the haemocompatibility of polylactide-polyglycolide in vitro. , 1997, Biomaterials.

[29]  E. Cera,et al.  A simple activity assay for thrombin and hirudin , 1994, Journal of protein chemistry.

[30]  F. Markwardt.  Hirudin: The Promising Antithrombotic , 1992 .

[31]  W. Bode,et al.  Crystal structure of the thrombin‐hirudin complex: a novel mode of serine protease inhibition. , 1990, The EMBO journal.

[32]  R. Colman,et al.  Mechanism of transient adsorption of fibrinogen from plasma to solid surfaces: role of the contact and fibrinolytic systems. , 1988, Blood.

[33]  L. Knight,et al.  Radiolabeling of Fibrinogen Using the Iodogen Technique , 1981, Thrombosis and Haemostasis.