Severe hypothermia, bradycardia and cardiac arrest in association with risperidone

Antipsychotic medications, including risperidone, are widely used in the treatment of psychiatric disorders, including schizophrenia. While hyperthermia is an establish adverse effect of these medications, less is known about the rare occurrence of hypothermia. We present two patients who developed hypothermia, bradycardia and cardiac arrest in association with risperidone. We briefly review previously similarly reported cases.

[1]  J. Bueno-de-Mesquita,et al.  Hypothermia due to Antipsychotic Medication: A Systematic Review , 2017, Front. Psychiatry.

[2]  R. Freudenmann,et al.  Mild Hypothermia in a Child with Low-Dose Risperidone. , 2017, Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie.

[3]  Masaru Nakamura,et al.  Prolactin Levels After Switching to Paliperidone Palmitate in Patients with Schizophrenia. , 2016, Innovations in clinical neuroscience.

[4]  D. Kamp,et al.  Hypothermia in a patient with Alzheimer’s disease receiving a combination therapy with risperidone and pipamperone , 2016, Therapeutic advances in psychopharmacology.

[5]  J. Asensio,et al.  Management of accidental hypothermia and cold injury. , 2014, Current problems in surgery.

[6]  M. Perera,et al.  De Novo delayed onset hypothermia secondary to therapeutic doses of risperidone in bipolar affective disorder , 2014, Therapeutic advances in psychopharmacology.

[7]  D. Fein,et al.  1235: A fatal case of risperidone induced hypothermia , 2013 .

[8]  P. Bookstaver,et al.  Possible long‐acting risperidone‐induced hypothermia precipitating phenytoin toxicity in an elderly patient , 2011, Journal of clinical pharmacy and therapeutics.

[9]  E. Beers,et al.  Hypothermia following antipsychotic drug use , 2007, European Journal of Clinical Pharmacology.

[10]  Christopher M. Whinney,et al.  Hypothermia in a patient receiving risperidone and paroxetine. , 2006, Journal of clinical psychopharmacology.

[11]  F. López-Muñoz,et al.  History of the discovery and clinical introduction of chlorpromazine. , 2005, Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists.

[12]  D. Farver,et al.  Atypical antipsychotic induced mild hypothermia. , 2003, South Dakota journal of medicine.

[13]  C. Nemeroff,et al.  The role of neurotensin in the pathophysiology of schizophrenia and the mechanism of action of antipsychotic drugs , 2001, Biological Psychiatry.

[14]  M. Hersch,et al.  Hypothermia Induced by risperidone and olanzapine in a patient with Prader‐Willi syndrome , 1998, The Medical journal of Australia.

[15]  D. Paterson,et al.  Should third‐generation cephalosporins be the empirical treatment of choice for severe community‐acquired pneumonia in adults? , 1998, The Medical journal of Australia.

[16]  C. Nemeroff,et al.  CSF neurotensin concentrations and antipsychotic treatment in schizophrenia and schizoaffective disorder. , 1997, The American journal of psychiatry.

[17]  M. Lin,et al.  Haloperidol produces hypothermic effects in rats , 1979, Experientia.

[18]  C. Chai,et al.  THE ENHANCEMENT OF CHLORPROMAZINE‐INDUCED HYPOTHERMIA BY LESIONS IN THE ANTERIOR HYPOTHALAMUS , 1977, British journal of pharmacology.

[19]  J. Dundee,et al.  CHLORPROMAZINE AND THE PRODUCTION OF HYPOTHERMIA , 1954, Anaesthesia.

[20]  T. Nagamine.  Complete Recovery from Cardiac Arrest Caused by Risperidone-induced Hypothermia. , 2016, Innovations in clinical neuroscience.