Dopaminergic modulation of striatal networks in health and Parkinson's disease

In the last couple of years, there have been significant advances in our understanding of how dopamine modulates striatal circuits underlying goal-directed behaviors and how therapeutic interventions intended to normalize disordered dopaminergic signaling can go awry. This review summarizes some of the advances in this field with a translational focus on Parkinson's disease.

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[42]  Bernardo L Sabatini,et al.  Phosphorylation of Ser1166 on GluN2B by PKA Is Critical to Synaptic NMDA Receptor Function and Ca2+ Signaling in Spines , 2014, The Journal of Neuroscience.

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[50]  Joshua L Plotkin,et al.  Differential Excitability and Modulation of Striatal Medium Spiny Neuron Dendrites , 2008, The Journal of Neuroscience.

[51]  D. Surmeier,et al.  Dichotomous Anatomical Properties of Adult Striatal Medium Spiny Neurons , 2008, The Journal of Neuroscience.

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[54]  Alexander Hammers,et al.  Glutamate NMDA receptor dysregulation in Parkinson's disease with dyskinesias. , 2011, Brain : a journal of neurology.

[55]  Joshua L. Plotkin,et al.  Strain-Specific Regulation of Striatal Phenotype in Drd2-eGFP BAC Transgenic Mice , 2012, The Journal of Neuroscience.

[56]  Denis Hervé,et al.  Gαolf Mutation Allows Parsing the Role of cAMP-Dependent and Extracellular Signal-Regulated Kinase-Dependent Signaling in l-3,4-Dihydroxyphenylalanine-Induced Dyskinesia , 2012, The Journal of Neuroscience.

[57]  C. Kellendonk,et al.  Striatal D2 Receptors Regulate Dendritic Morphology of Medium Spiny Neurons via Kir2 Channels , 2012, The Journal of Neuroscience.

[58]  Bryan L Roth,et al.  Direct-Pathway Striatal Neurons Regulate the Retention of Decision-Making Strategies , 2013, The Journal of Neuroscience.

[59]  P. Greengard,et al.  Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia , 2014, Proceedings of the National Academy of Sciences.

[60]  R. Moratalla,et al.  L-DOPA Treatment Selectively Restores Spine Density in Dopamine Receptor D2–Expressing Projection Neurons in Dyskinetic Mice , 2014, Biological Psychiatry.

[61]  C. Konradi,et al.  Maladaptive striatal plasticity in L-DOPA-induced dyskinesia. , 2010, Progress in brain research.

[62]  C. Gerfen,et al.  Modulation of striatal projection systems by dopamine. , 2011, Annual review of neuroscience.

[63]  Steven S. Vogel,et al.  Concurrent Activation of Striatal Direct and Indirect Pathways During Action Initiation , 2013, Nature.

[64]  Anatol C. Kreitzer,et al.  Striatal microcircuitry and movement disorders , 2012, Trends in Neurosciences.

[65]  L. Trudeau,et al.  Dopamine facilitates dendritic spine formation by cultured striatal medium spiny neurons through both D1 and D2 dopamine receptors , 2013, Neuropharmacology.

[66]  R. Gainetdinov,et al.  The Physiology, Signaling, and Pharmacology of Dopamine Receptors , 2011, Pharmacological Reviews.

[67]  J. Kerr,et al.  Dopamine Receptor Activation Is Required for Corticostriatal Spike-Timing-Dependent Plasticity , 2008, The Journal of Neuroscience.

[68]  Anatol C. Kreitzer,et al.  Differential Innervation of Direct- and Indirect-Pathway Striatal Projection Neurons , 2013, Neuron.

[69]  S. Snyder,et al.  Rhes, a striatal–enriched small G–protein, mediates mTOR signaling and L–DOPA–induced dyskinesia , 2011, Nature Neuroscience.

[70]  Steven Finkbeiner,et al.  Rapid Target-Specific Remodeling of Fast-Spiking Inhibitory Circuits after Loss of Dopamine , 2011, Neuron.

[71]  C. Parsons,et al.  GluN2A and GluN2B NMDA receptor subunits differentially modulate striatal output pathways and contribute to levodopa-induced abnormal involuntary movements in dyskinetic rats. , 2013, ACS chemical neuroscience.

[72]  P. Calabresi,et al.  Inhibition of phosphodiesterases rescues striatal long-term depression and reduces levodopa-induced dyskinesia. , 2011, Brain : a journal of neurology.