Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction

[1]  Marilyne Labasque,et al.  GPI‐anchored proteins at the node of Ranvier , 2010, FEBS letters.

[2]  Xianlin Han,et al.  Absence of oligodendroglial glucosylceramide synthesis does not result in CNS myelin abnormalities or alter the dysmyelinating phenotype of CGT‐deficient mice , 2010, Glia.

[3]  Y. Matsuoka,et al.  Elimination of GD3 synthase improves memory and reduces amyloid-β plaque load in transgenic mice , 2009, Neurobiology of Aging.

[4]  F. Barrantes,et al.  Sphingolipid/cholesterol regulation of neurotransmitter receptor conformation and function. , 2009, Biochimica et biophysica acta.

[5]  R. Ledeen,et al.  Sialidase occurs in both membranes of the nuclear envelope and hydrolyzes endogenous GD1a , 2009, Journal of neurochemistry.

[6]  R. Ledeen,et al.  Sodium-calcium exchanger complexed with GM1 ganglioside in nuclear membrane transfers calcium from nucleoplasm to endoplasmic reticulum , 2009, Proceedings of the National Academy of Sciences.

[7]  N. Matsumoto,et al.  Mice lacking ganglioside GM3 synthase exhibit complete hearing loss due to selective degeneration of the organ of Corti , 2009, Proceedings of the National Academy of Sciences.

[8]  M. Mattson,et al.  Tumor necrosis factor‐α‐induced neutral sphingomyelinase‐2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors , 2009, Journal of neurochemistry.

[9]  Y. Hannun,et al.  Roles and regulation of secretory and lysosomal acid sphingomyelinase. , 2009, Cellular signalling.

[10]  K. Yuyama,et al.  Late endocytic dysfunction as a putative cause of amyloid fibril formation in Alzheimer’s disease , 2009, Journal of neurochemistry.

[11]  E. Masliah,et al.  Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies. , 2009, The American journal of pathology.

[12]  A. Salminen,et al.  Siglec receptors and hiding plaques in Alzheimer's disease , 2009, Journal of Molecular Medicine.

[13]  E. Hogan,et al.  Ceramide and neurodegeneration: Susceptibility of neurons and oligodendrocytes to cell damage and death , 2009, Journal of the Neurological Sciences.

[14]  K. Itoh,et al.  Tyrosine Kinase Activity of Epidermal Growth Factor Receptor Is Regulated by GM3 Binding through Carbohydrate to Carbohydrate Interactions* , 2009, Journal of Biological Chemistry.

[15]  B. Benitez,et al.  Regulation of ceramide-induced neuronal death: Cell metabolism meets neurodegeneration , 2009, Brain Research Reviews.

[16]  G. Ming,et al.  Axonal Protective Effects of the Myelin-Associated Glycoprotein , 2009, The Journal of Neuroscience.

[17]  Takako Sasaki,et al.  Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth , 2009, Journal of Cell Science.

[18]  W. Lencer,et al.  Ceramide activates JNK to inhibit a cAMP‐gated K+ conductance and Cl‐ secretion in intestinal epithelia , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[19]  A. Cerasa,et al.  Anti-GM1 antibodies are not associated with cerebral atrophy in patients with multiple sclerosis , 2009, Multiple sclerosis.

[20]  E. Gulbins,et al.  Ceramide-enriched membrane domains--structure and function. , 2009, Biochimica et biophysica acta.

[21]  F. Goñi,et al.  Effects of ceramide and other simple sphingolipids on membrane lateral structure. , 2009, Biochimica et biophysica acta.

[22]  G. Kroemer,et al.  Autophagy in aging, disease and death: the true identity of a cell death impostor , 2009, Cell Death and Differentiation.

[23]  K. Iwabuchi,et al.  Role of very long fatty acid-containing glycosphingolipids in membrane organization and cell signaling: the model of lactosylceramide in neutrophils , 2009, Glycoconjugate Journal.

[24]  Toshinori Sato,et al.  Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid beta-protein fibrillogenesis. , 2008, Biochimica et biophysica acta.

[25]  T. Bártfai,et al.  A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta. , 2008, Brain : a journal of neurology.

[26]  Eigen R. Peralta,et al.  Ceramide starves cells to death by downregulating nutrient transporter proteins , 2008, Proceedings of the National Academy of Sciences.

[27]  E. Schuchman,et al.  The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[28]  B. Schraven,et al.  The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1 , 2008, The Journal of cell biology.

[29]  M. Wiznitzer,et al.  Ganglioside depletion and EGF responses of human GM3 synthase-deficient fibroblasts. , 2008, Glycobiology.

[30]  Jeffrey H. Chuang,et al.  Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria , 2008, Journal of neurochemistry.

[31]  M. P. McDonald,et al.  Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease--a review. , 2008, Journal of lipid research.

[32]  R. Ledeen,et al.  Thematic Review Series: Sphingolipids. Nuclear sphingolipids: metabolism and signaling** This study was supported by National Institutes of Health grant 2RO1 NS033912. Published, JLR Papers in Press, March 9, 2008. , 2008, Journal of Lipid Research.

[33]  L. Puglielli,et al.  Aging of the brain, neurotrophin signaling, and Alzheimer's disease: Is IGF1-R the common culprit? , 2008, Neurobiology of Aging.

[34]  B. Kedjouar,et al.  Functions of sphingolipid metabolism in mammals--lessons from genetic defects. , 2008, Biochimica et biophysica acta.

[35]  Yoshiyuki Suzuki,et al.  Enhanced autophagy and mitochondrial aberrations in murine G(M1)-gangliosidosis. , 2008, Biochemical and biophysical research communications.

[36]  A. Duchemin,et al.  GM1‐induced activation of phosphatidylinositol 3‐kinase: involvement of Trk receptors , 2008, Journal of neurochemistry.

[37]  S. Hakomori,et al.  Functional role of glycosphingolipids and gangliosides in control of cell adhesion, motility, and growth, through glycosynaptic microdomains. , 2008, Biochimica et biophysica acta.

[38]  M. Colombini,et al.  Ceramide synthesis in the endoplasmic reticulum can permeabilize mitochondria to proapoptotic proteins Published, JLR Papers in Press, December 11, 2007. , 2008, Journal of Lipid Research.

[39]  P. V. Van Veldhoven,et al.  Anomalous surface distribution of glycosyl phosphatidyl inositol-anchored proteins in neurons lacking acid sphingomyelinase. , 2007, Molecular biology of the cell.

[40]  S. Kar,et al.  Internalization of β-Amyloid Peptide by Primary Neurons in the Absence of Apolipoprotein E* , 2007, Journal of Biological Chemistry.

[41]  J. Sutcliffe,et al.  Glycolipid and ganglioside metabolism imbalances in Huntington's disease , 2007, Neurobiology of Disease.

[42]  Y. Hathout,et al.  Alteration of ganglioside synthesis by GM3 synthase knockout in murine embryonic fibroblasts. , 2007, Biochimica et biophysica acta.

[43]  P. Matarrese,et al.  Do mitochondria act as “cargo boats” in the journey of GD3 to the nucleus during apoptosis? , 2007, FEBS letters.

[44]  Y. Igarashi,et al.  Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance , 2007, Proceedings of the National Academy of Sciences.

[45]  K. Yanagisawa Role of gangliosides in Alzheimer's disease. , 2007, Biochimica et biophysica acta.

[46]  M. Nowycky,et al.  Induction of Calcium Influx through TRPC5 Channels by Cross-Linking of GM1 Ganglioside Associated with α5β1 Integrin Initiates Neurite Outgrowth , 2007, The Journal of Neuroscience.

[47]  M. Mattson,et al.  Associative and predictive biomarkers of dementia in HIV-1–infected patients , 2007, Neurology.

[48]  K. Hirata,et al.  Gangliosides contribute to stability of paranodal junctions and ion channel clusters in myelinated nerve fibers , 2007, Glia.

[49]  T. Baram,et al.  New Roles for Interleukin-1 Beta in the Mechanisms of Epilepsy , 2007, Epilepsy currents.

[50]  Min Zhu,et al.  GM1 Specifically Interacts with α-Synuclein and Inhibits Fibrillation† , 2007 .

[51]  Min Zhu,et al.  GM1 specifically interacts with alpha-synuclein and inhibits fibrillation. , 2007, Biochemistry.

[52]  M. Cabot,et al.  Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. , 2006, Biochimica et biophysica acta.

[53]  P. Brophy,et al.  Disruption of neurofascin localization reveals early changes preceding demyelination and remyelination in multiple sclerosis. , 2006, Brain : a journal of neurology.

[54]  T. Bártfai,et al.  IL‐1β induces a MyD88‐dependent and ceramide‐mediated activation of Src in anterior hypothalamic neurons , 2006, Journal of neurochemistry.

[55]  R. Pagano,et al.  Distinct mechanisms of clathrin-independent endocytosis have unique sphingolipid requirements. , 2006, Molecular biology of the cell.

[56]  S. Sonnino,et al.  Plasma membrane production of ceramide from ganglioside GM3 in human fibroblasts , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[57]  R. Kolesnick,et al.  Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations. , 2006, Mitochondrion.

[58]  T. Bártfai,et al.  Ceramide mediates the rapid phase of febrile response to IL-1beta. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[59]  E. Posse de Chaves Sphingolipids in apoptosis, survival and regeneration in the nervous system. , 2006, Biochimica et biophysica acta.

[60]  E. Gulbins,et al.  Physiological and pathophysiological aspects of ceramide. , 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

[61]  J. Joseph,et al.  Age-related changes in neutral sphingomyelin-specific phospholipase C activity in striatum, hippocampus, and frontal cortex: Implication for sensitivity to stress and inflammation , 2005, Neurochemistry International.

[62]  P. Schwille,et al.  Lipids as Modulators of Proteolytic Activity of BACE , 2005, Journal of Biological Chemistry.

[63]  I. Mocchetti Exogenous gangliosides, neuronal plasticity and repair, and the neurotrophins , 2005, Cellular and Molecular Life Sciences CMLS.

[64]  T. Crawford,et al.  Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: Neuropathology and behavioral deficits in single- and double-null mice , 2005, Experimental Neurology.

[65]  M. Heneka,et al.  Inhibition of Glycosphingolipid Biosynthesis Reduces Secretion of the β-Amyloid Precursor Protein and Amyloid β-Peptide*[boxs] , 2005, Journal of Biological Chemistry.

[66]  C. Dotti,et al.  Asymmetric membrane ganglioside sialidase activity specifies axonal fate , 2005, Nature Neuroscience.

[67]  I. Roberts,et al.  Gangliosides for acute spinal cord injury. , 2005, The Cochrane database of systematic reviews.

[68]  M. Heneka,et al.  Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide. , 2005, The Journal of biological chemistry.

[69]  K. Törnquist,et al.  Tumor necrosis factor alpha and ceramide depolarise the resting membrane potential of thyroid FRTL-5 cells via a protein kinase Czeta-dependent regulation of K+ channels. , 2004, Cellular signalling.

[70]  R. Dwek,et al.  Infantile-onset symptomatic epilepsy syndrome caused by a homozygous loss-of-function mutation of GM3 synthase , 2004, Nature Genetics.

[71]  K. Beyreuther,et al.  GM1 ganglioside regulates the proteolysis of amyloid precursor protein , 2004, Molecular Psychiatry.

[72]  S. Fujita,et al.  Accelerated Aβ aggregation in the presence of GM1‐ganglioside‐accumulated synaptosomes of aged apoE4‐knock‐in mouse brain , 2004, FEBS letters.

[73]  R. Simari,et al.  Selective stimulation of caveolar endocytosis by glycosphingolipids and cholesterol. , 2004, Molecular biology of the cell.

[74]  C. Bauvy,et al.  Ceramide-mediated Macroautophagy Involves Inhibition of Protein Kinase B and Up-regulation of Beclin 1* , 2004, Journal of Biological Chemistry.

[75]  M. Mattson,et al.  Perturbation of sphingolipid metabolism and ceramide production in HIV‐dementia , 2004, Annals of neurology.

[76]  G. Tettamanti Ganglioside/glycosphingolipid turnover: New concepts , 2003, Glycoconjugate Journal.

[77]  N. Loberto,et al.  Synthesis of radioactive and photoactivable ganglioside derivatives for the study of ganglioside-protein interactions , 2003, Glycoconjugate Journal.

[78]  H. Koga,et al.  Stable Transfection of GM1 Synthase Gene into GM1-Deficient NG108-15 Cells, CR-72 Cells, Rescues the Responsiveness of TRK-Neurotrophin Receptor to Its Ligand, NGF , 2002, Neurochemical Research.

[79]  Fu-yu Yang,et al.  Mechanistic study of modulation of SR Ca2+-ATPase activity by gangliosides GM1 and GM3 through some biophysical measurements , 1999, Glycoconjugate Journal.

[80]  N. Loberto,et al.  Interactions between gangliosides and proteins in the exoplasmic leaflet of neuronal plasma membranes: A study performed with a tritium-labeled GM1 derivative containing a photoactivable group linked to the oligosaccharide chain , 2004, Glycoconjugate Journal.

[81]  Stefani N. Thomas,et al.  Aberrant sphingomyelin/ceramide metabolic-induced neuronal endosomal/lysosomal dysfunction: potential pathological consequences in age-related neurodegeneration. , 2003, Advanced drug delivery reviews.

[82]  F. Platt,et al.  Inhibition of Calcium Uptake via the Sarco/Endoplasmic Reticulum Ca2+-ATPase in a Mouse Model of Sandhoff Disease and Prevention by Treatment with N-Butyldeoxynojirimycin* , 2003, Journal of Biological Chemistry.

[83]  R. Proia,et al.  Enhanced insulin sensitivity in mice lacking ganglioside GM3 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[84]  M. Pender,et al.  Increased circulating T cell reactivity to GM3 and GQ1b gangliosides in primary progressive multiple sclerosis , 2003, Journal of Clinical Neuroscience.

[85]  M. Verheij,et al.  Ceramide: second messenger or modulator of membrane structure and dynamics? , 2003, The Biochemical journal.

[86]  C. Lemere,et al.  Novel Therapeutic Approach for the Treatment of Alzheimer's Disease by Peripheral Administration of Agents with an Affinity to β-Amyloid , 2003, The Journal of Neuroscience.

[87]  C. Lemere,et al.  Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid. , 2003, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[88]  F. Malisan,et al.  GD3 ganglioside and apoptosis. , 2002, Biochimica et biophysica acta.

[89]  A. Bachis,et al.  Gangliosides Activate Trk Receptors by Inducing the Release of Neurotrophins* , 2002, The Journal of Biological Chemistry.

[90]  J. Fantini,et al.  Lipid rafts: structure, function and role in HIV, Alzheimer's and prion diseases , 2002, Expert Reviews in Molecular Medicine.

[91]  E. Miljan,et al.  Regulation of Growth Factor Receptors by Gangliosides , 2002, Science's STKE.

[92]  F. Goñi,et al.  Role of sphingomyelinase and ceramide in modulating rafts: do biophysical properties determine biologic outcome? , 2002, FEBS letters.

[93]  G. Bråne,et al.  Alzheimer Disease – Effect of Continuous Intracerebroventricular Treatment with GM1 Ganglioside and a Systematic Activation Programme , 2002, Dementia and Geriatric Cognitive Disorders.

[94]  M Zappia,et al.  Anti‐GM1 ganglioside antibodies in Parkinson's disease , 2002, Acta neurologica Scandinavica.

[95]  Ken Jacobson,et al.  A Role for Lipid Shells in Targeting Proteins to Caveolae, Rafts, and Other Lipid Domains , 2002, Science.

[96]  A. Caricasole,et al.  β-Amyloid-Induced Synthesis of the Ganglioside Gd3 Is a Requisite for Cell Cycle Reactivation and Apoptosis in Neurons , 2002, The Journal of Neuroscience.

[97]  Kazuro Furukawa,et al.  Overexpression of Ganglioside GM1 Results in the Dispersion of Platelet-derived Growth Factor Receptor from Glycolipid-enriched Microdomains and in the Suppression of Cell Growth Signals* , 2002, The Journal of Biological Chemistry.

[98]  Y. Hannun,et al.  Mitochondria and ceramide: intertwined roles in regulation of apoptosis. , 2002, Advances in enzyme regulation.

[99]  R. Campenot,et al.  Ceramide Inhibits Axonal Growth and Nerve Growth Factor Uptake without Compromising the Viability of Sympathetic Neurons* , 2001, The Journal of Biological Chemistry.

[100]  M. Mattson,et al.  Sphingomyelin and ceramide as regulators of development and lifespan , 2001, Mechanisms of Ageing and Development.

[101]  N. Loberto,et al.  Changes in the Lipid Turnover, Composition, and Organization, as Sphingolipid-enriched Membrane Domains, in Rat Cerebellar Granule Cells Developing in Vitro * , 2001, The Journal of Biological Chemistry.

[102]  Tadashi Yamamoto,et al.  Involvement of Gangliosides in Glycosylphosphatidylinositol-anchored Neuronal Cell Adhesion Molecule TAG-1 Signaling in Lipid Rafts* , 2000, The Journal of Biological Chemistry.

[103]  S. Sonnino,et al.  Ganglioside molecular species containing C18- and C20-sphingosine in mammalian nervous tissues and neuronal cell cultures. , 2000, Biochimica et biophysica acta.

[104]  W. Oertel,et al.  Systemic Treatment with GM1 Ganglioside Improves Survival and Function of Cryopreserved Embryonic Midbrain Grafted to the 6-Hydroxydopamine-Lesioned Rat Striatum , 2000, Experimental Neurology.

[105]  W. Zundel,et al.  Caveolin 1-Mediated Regulation of Receptor Tyrosine Kinase-Associated Phosphatidylinositol 3-Kinase Activity by Ceramide , 2000, Molecular and Cellular Biology.

[106]  T. Bártfai,et al.  ACTIVATION OF NEUTRAL SPHINGOMYELINASE BY IL-1β REQUIRES THE TYPE 1 INTERLEUKIN 1 RECEPTOR , 2000 .

[107]  T. Crawford,et al.  Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[108]  J. Schneider GM1 ganglioside in the treatment of Parkinson's disease. , 2008, Annals of the New York Academy of Sciences.

[109]  J. Schneider GM1 Ganglioside in the Treatment of Parkinson's Disease a , 1998 .

[110]  Milton Alter GM1 Ganglioside for Acute Ischemic Stroke: Trial Design Issues , 1998, Annals of the New York Academy of Sciences.

[111]  F. Lang,et al.  Tyrosine kinase-dependent activation of a chloride channel in CD95-induced apoptosis in T lymphocytes. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[112]  F. Maxfield,et al.  Sphingomyelinase Treatment Induces ATP-independent Endocytosis , 1998, The Journal of cell biology.

[113]  M. Hamaguchi,et al.  Ganglioside GM1 binds to the Trk protein and regulates receptor function. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[114]  L. Svennerholm,et al.  Membrane Lipids of Adult Human Brain: Lipid Composition of Frontal and Temporal Lobe in Subjects of Age 20 to 100 Years , 1994, Journal of neurochemistry.

[115]  B. Hempstead,et al.  Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation , 1992, Neuron.

[116]  R. Brady,et al.  Deficient Ganglioside Biosynthesis: a novel human sphingolipidosis. , 1975, Science.