Pre-treatment protoporphyrin IX concentration in actinic keratosis lesions may be a predictive biomarker of response to aminolevulinic-acid based photodynamic therapy.

[1]  Acta Dermato-Venereologica Variation in Epidermal Morphology in Human Skin at Different Body Sites as Measured by Reflectance Confocal Microscopy , 2016 .

[2]  R. Dellavalle,et al.  Long-term Efficacy of Topical Fluorouracil Cream, 5%, for Treating Actinic Keratosis: A Randomized Clinical Trial. , 2015, JAMA dermatology.

[3]  A. Armstrong,et al.  Efficacy of photodynamic therapy vs other interventions in randomized clinical trials for the treatment of actinic keratoses: a systematic review and meta-analysis. , 2014, JAMA dermatology.

[4]  R. Anderson,et al.  Temperature-Modulated Photodynamic Therapy for the Treatment of Actinic Keratosis on the Extremities: A Pilot Study , 2014, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[5]  Tayyaba Hasan,et al.  Dual-channel red/blue fluorescence dosimetry with broadband reflectance spectroscopic correction measures protoporphyrin IX production during photodynamic therapy of actinic keratosis , 2014, Journal of biomedical optics.

[6]  G. Kolde Follow‐up analysis of the efficacy of photodynamic therapy in actinic keratosis , 2013, The British journal of dermatology.

[7]  Filippo Piffaretti,et al.  Correlation between Protoporphyrin IX Fluorescence Intensity, Photobleaching, Pain and Clinical Outcome of Actinic Keratosis Treated by Photodynamic Therapy , 2013, Dermatology.

[8]  L. Rhodes,et al.  Prostaglandin E2 and nitric oxide mediate the acute inflammatory (erythemal) response to topical 5‐aminolaevulinic acid photodynamic therapy in human skin , 2013, The British journal of dermatology.

[9]  S. Ibbotson,et al.  The acute inflammatory response to photodynamic therapy , 2013, The British journal of dermatology.

[10]  Sanjay Anand,et al.  Biomodulatory approaches to photodynamic therapy for solid tumors. , 2012, Cancer letters.

[11]  Aditya K. Gupta,et al.  Interventions for actinic keratoses. , 2012, The Cochrane database of systematic reviews.

[12]  R. Bissonnette,et al.  Short incubation photodynamic therapy with methylaminolevulinate and no occlusion for the treatment of actinic keratoses. , 2012, Journal of the American Academy of Dermatology.

[13]  H. Wulf,et al.  The relation between methyl aminolevulinate concentration and inflammation after photodynamic therapy in healthy volunteers , 2012, Photochemical & Photobiological Sciences.

[14]  T. Hasan,et al.  Vitamin D3 enhances the apoptotic response of epithelial tumors to aminolevulinate-based photodynamic therapy. , 2011, Cancer research.

[15]  S. Campbell,et al.  The effect of air cooling pain relief on protoporphyrin IX photobleaching and clinical efficacy during dermatological photodynamic therapy. , 2011, Journal of photochemistry and photobiology. B, Biology.

[16]  S. Feldman,et al.  Progression of actinic keratosis to squamous cell carcinoma revisited: clinical and treatment implications. , 2011, Cutis.

[17]  S. Ibbotson,et al.  A review of pain experienced during topical photodynamic therapy--our experience in Dundee. , 2011, Photodiagnosis and photodynamic therapy.

[18]  S. Campbell,et al.  Protoporphyrin IX photobleaching during the light irradiation phase of standard dermatological methyl-aminolevulinate photodynamic therapy. , 2010, Photodiagnosis and photodynamic therapy.

[19]  Edward V Maytin,et al.  Noninvasive fluorescence monitoring of protoporphyrin IX production and clinical outcomes in actinic keratoses following short-contact application of 5-aminolevulinate. , 2010, Journal of biomedical optics.

[20]  Alison Curnow,et al.  The relationship between protoporphyrin IX photobleaching during real‐time dermatological methyl‐aminolevulinate photodynamic therapy (MAL‐PDT) and subsequent clinical outcome , 2010, Lasers in surgery and medicine.

[21]  A. Enk,et al.  Factors influencing pain intensity during topical photodynamic therapy of complete cosmetic units for actinic keratoses. , 2010, Journal of the American Academy of Dermatology.

[22]  E. Maytin,et al.  Pain associated with aminolevulinic acid-photodynamic therapy of skin disease. , 2009, Journal of the American Academy of Dermatology.

[23]  T. Hasan,et al.  Low-Dose Methotrexate Enhances Aminolevulinate-Based Photodynamic Therapy in Skin Carcinoma Cells In vitro and In vivo , 2009, Clinical Cancer Research.

[24]  A. Ros,et al.  Short incubation with methyl aminolevulinate for photodynamic therapy of actinic keratoses , 2009, Journal of the European Academy of Dermatology and Venereology : JEADV.

[25]  P. van Erp,et al.  Pretreatment to Enhance Protoporphyrin IX Accumulation in Photodynamic Therapy , 2008, Dermatology.

[26]  T. Hasan,et al.  Prospects for the use of differentiation‐modulating agents as adjuvant of photodynamic therapy for proliferative dermatoses , 2008, The Journal of dermatology.

[27]  V. von Felbert,et al.  Photodynamic Therapy in the Treatment of Actinic Keratosis † , 2008, Photochemistry and photobiology.

[28]  Ann-Marie Wennberg,et al.  Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus. International Society for Photodynamic Therapy in Dermatology, 2005. , 2007, Journal of the American Academy of Dermatology.

[29]  J. Rao,et al.  Photodynamic therapy for actinic keratoses. , 2007, Dermatologic clinics.

[30]  E. Tschen,et al.  Photodynamic therapy using aminolaevulinic acid for patients with nonhyperkeratotic actinic keratoses of the face and scalp: phase IV multicentre clinical trial with 12‐month follow up , 2006, The British journal of dermatology.

[31]  S. Ibbotson,et al.  Characteristics of 5‐aminolaevulinic acid‐induced protoporphyrin IX fluorescence in human skin in vivo , 2006, Photodermatology, photoimmunology & photomedicine.

[32]  P. V. D. van de Kerkhof,et al.  Correlation between macroscopic fluorescence and protoporphyrin IX content in psoriasis and actinic keratosis following application of aminolevulinic acid. , 2005, The Journal of investigative dermatology.

[33]  K. Svanberg,et al.  A randomized multicenter study to compare two treatment regimens of topical methyl aminolevulinate (Metvix)-PDT in actinic keratosis of the face and scalp. , 2005, Acta dermato-venereologica.

[34]  Barbara A Gilchrest,et al.  A trial of short incubation, broad-area photodynamic therapy for facial actinic keratoses and diffuse photodamage. , 2004, Archives of dermatology.

[35]  E. Jeffes,et al.  Photodynamic therapy with aminolevulinic acid topical solution and visible blue light in the treatment of multiple actinic keratoses of the face and scalp: investigator-blinded, phase 3, multicenter trials. , 2004, Archives of dermatology.

[36]  D. Piacquadio,et al.  Short incubation PDT versus 5-FU in treating actinic keratoses. , 2003, Journal of drugs in dermatology : JDD.

[37]  L E Rhodes,et al.  The effect of an iron chelating agent on protoporphyrin IX levels and phototoxicity in topical 5‐aminolaevulinic acid photodynamic therapy , 2003, The British journal of dermatology.

[38]  J. Moan,et al.  Temperature Effect on Accumulation of Protoporphyrin IX After Topical Application of 5-Aminolevulinic Acid and its Methylester and Hexylester Derivatives in Normal Mouse Skin¶ , 2002, Photochemistry and photobiology.

[39]  E. Jeffes Levulan ® : the first approved topical photosensitizer for the treatment of actinic keratosis , 2002, The Journal of dermatological treatment.

[40]  E. Jeffes,et al.  Photodynamic therapy of actinic keratoses with topical aminolevulinic acid hydrochloride and fluorescent blue light. , 2001, Journal of the American Academy of Dermatology.

[41]  J. Kennedy,et al.  The Monitoring of ALA-Induced Protoporphyrin IX Accumulation and Clearance in Patients with Skin Lesions by In Vivo Surface-Detected Fluorescence Spectroscopy , 1999, Lasers in Medical Science.

[42]  H Stepp,et al.  Pharmacokinetics of 5-aminolevulinic acid-induced protoporphyrin IX in skin and blood. , 1997, Journal of photochemistry and photobiology. B, Biology.