Mutagenicity, carcinogenicity, and teratogenicity of acrylonitrile.

[1]  G. Swaen,et al.  Mortality Update of Workers Exposed to Acrylonitrile in The Netherlands , 2004, Scandinavian journal of work, environment & health.

[2]  S. Miller,et al.  Exposure to toxic air contaminants in environmental tobacco smoke: an assessment for California based on personal monitoring data. , 1998, Journal of exposure analysis and environmental epidemiology.

[3]  Gary M Williams,et al.  Formation of 8-oxodeoxyguanosine in brain DNA of rats exposed to acrylonitrile , 1998, Archives of Toxicology.

[4]  S. Felter,et al.  Acrylonitrile: a reevaluation of the database to support an inhalation cancer risk assessment. , 1997, Regulatory toxicology and pharmacology : RTP.

[5]  T. Fennell,et al.  Urinary metabolites from F344 rats and B6C3F1 mice coadministered acrylamide and acrylonitrile for 1 or 5 days. , 1997, Chemical research in toxicology.

[6]  Junyu Li,et al.  Dose dependence of covalent binding of acrylonitrile to tissue protein and globin in rats. , 1997, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[7]  E. Bergmark,et al.  Hemoglobin adducts of acrylamide and acrylonitrile in laboratory workers, smokers and nonsmokers. , 1997, Chemical research in toxicology.

[8]  G. Sweetman,et al.  Monitoring of exposure to acrylonitrile by determination of N-(2-cyanoethyl)valine at the N-terminal position of haemoglobin. , 1996, Carcinogenesis.

[9]  Robert F. Herrick,et al.  Exposure Assessment for a Study of Workers Exposed to Acrylonitrile. III: Evaluation of Exposure Assessment Methods , 1996 .

[10]  K. Steenland,et al.  Review of occupational lung carcinogens. , 1996, American journal of industrial medicine.

[11]  A. E. Ahmed,et al.  Intestinal toxicity of acrylonitrile: in vitro metabolism by intestinal cytochrome P450 2E1. , 1995, Toxicology and applied pharmacology.

[12]  G. L. Kedderis,et al.  Conjugation of acrylonitrile and 2-cyanoethylene oxide with hepatic glutathione. , 1995, Toxicology and applied pharmacology.

[13]  M E Andersen,et al.  A physiologically based dosimetry description of acrylonitrile and cyanoethylene oxide in the rat. , 1995, Toxicology and applied pharmacology.

[14]  Robert F. Herrick,et al.  Exposure Assessment for a Study of Workers Exposed to Acrylonitrile. II. A Computerized Exposure Assessment Program , 1995 .

[15]  W. Wu,et al.  [An epidemiological study on reproductive effects in female workers exposed to acrylonitrile]. , 1995, Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine].

[16]  J A Swenberg,et al.  Monitoring exposure to acrylonitrile using adducts with N-terminal valine in hemoglobin. , 1994, Carcinogenesis.

[17]  K. Rothman Cancer occurrence among workers exposed to acrylonitrile. , 1994, Scandinavian journal of work, environment & health.

[18]  Ahmed E. Ahmed,et al.  Molecular interaction of [2,3-14C] acrylonitrile with DNA in gastric tissue of rat. , 1994, Journal of biochemical toxicology.

[19]  K. Crofton,et al.  Relationships between biomarkers of exposure and neurological effects in a group of workers exposed to acrylamide. , 1994, Toxicology and applied pharmacology.

[20]  J. Bonaventura,et al.  Application of electrospray ionization mass spectrometry for analysis of haemoglobin adducts with acrylonitrile. , 1994, Biochemical Society Transactions.

[21]  R. Schiestl,et al.  Evaluation of the yeast DEL assay with 10 compounds selected by the International Program on Chemical Safety for the evaluation of short-term tests for carcinogens. , 1994, Mutation research.

[22]  T. Fennell,et al.  Characterization of phosphodiester adducts produced by the reaction of cyanoethylene oxide with nucleotides. , 1994, Carcinogenesis.

[23]  G. L. Kedderis,et al.  Epoxidation of acrylonitrile by rat and human cytochromes P450. , 1993, Chemical research in toxicology.

[24]  T. Starr,et al.  Comparison of cancer risks projected from animal bioassays to epidemiologic studies of acrylonitrile-exposed workers. , 1993, Regulatory toxicology and pharmacology : RTP.

[25]  G. L. Kedderis,et al.  Induction of rat liver microsomal epoxide hydrolase by thiazole and pyrazine: hydrolysis of 2-cyanoethylene oxide. , 1993, Carcinogenesis.

[26]  G. L. Kedderis,et al.  Rodent tissue distribution of 2-cyanoethylene oxide, the epoxide metabolite of acrylonitrile. , 1993, Toxicology letters.

[27]  T. Fennell,et al.  Characterization of an adduct and its degradation product produced by the reaction of cyanoethylene oxide with deoxythymidine and DNA. , 1993, Carcinogenesis.

[28]  G. L. Kedderis,et al.  Dose-dependent urinary excretion of acrylonitrile metabolites by rats and mice. , 1993, Toxicology and applied pharmacology.

[29]  L. Costa,et al.  Determination of hemoglobin adducts in humans occupationally exposed to acrylamide. , 1993, Toxicology and applied pharmacology.

[30]  G. L. Kedderis,et al.  Species differences in the hydrolysis of 2-cyanoethylene oxide, the epoxide metabolite of acrylonitrile. , 1993, Carcinogenesis.

[31]  A. Saillenfait,et al.  Relative Developmental Toxicities of Inhaled Aliphatic Mononitriles in Rats , 1993 .

[32]  D Zaebst,et al.  Exposure assessment for a study of workers exposed to acrylonitrile. , 1992, Scandinavian journal of work, environment & health.

[33]  S. Z. Abdel‐Rahman,et al.  Pulmonary toxicity of acrylonitrile: covalent interaction and effect on replicative and unscheduled DNA synthesis in the lung. , 1992, Toxicology.

[34]  F. Sturmans,et al.  Mortality of workers exposed to acrylonitrile. , 1992, Journal of occupational medicine. : official publication of the Industrial Medical Association.

[35]  S. Z. Abdel‐Rahman,et al.  Acrylonitrile interaction with testicular DNA in rats. , 1992, Journal of biochemical toxicology.

[36]  G. L. Kedderis,et al.  Urinary metabolites of [1,2,3-13C]acrylonitrile in rats and mice detected by 13C nuclear magnetic resonance spectroscopy. , 1991, Chemical research in toxicology.

[37]  M. Farooqui,et al.  Assessment of the acute acrylonitrile-induced neurotoxicity in rats. , 1991, Neurotoxicology and teratology.

[38]  F. Guengerich,et al.  Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. , 1991, Chemical research in toxicology.

[39]  G. L. Kedderis,et al.  Species comparison of acrylonitrile epoxidation by microsomes from mice, rats and humans: relationship to epoxide concentrations in mouse and rat blood. , 1991, Carcinogenesis.

[40]  C. Osgood,et al.  Aneuploidy in Drosophila, IV. Inhalation studies on the induction of aneuploidy by nitriles. , 1991, Mutation research.

[41]  I. Gut,et al.  Effects of inhaled acrylic acid derivatives in rats. , 1990, Toxicology.

[42]  N. Page,et al.  Assessment of risk from exposure to acrylonitrile: the general approach used by a consultant. , 1990, Science of the Total Environment.

[43]  D. Salsburg Estimating dose response in chronic toxicity studies: 24-month administration of acrylonitrile in drinking water of Fischer 344 rats. , 1990, The Science of the total environment.

[44]  G. Stoner,et al.  Acrylonitrile-induced sister-chromatid exchanges and DNA single-strand breaks in adult human bronchial epithelial cells. , 1990, Mutation research.

[45]  L. Simionescu,et al.  Testosterone in sera of workers exposed to acrylonitrile. , 1990, Endocrinologie.

[46]  F. Zimmermann,et al.  Detection of induced mitotic chromosome loss in Saccharomyces cerevisiae--an interlaboratory assessment of 12 chemicals. , 1990, Mutation research.

[47]  R. Lauwerys,et al.  Lipid peroxidation in acrylonitrile‐treated rats, evidenced by elevated ethane production , 1989, Journal of applied toxicology : JAT.

[48]  S. Lacy,et al.  Metabolism of acrylonitrile to 2-cyanoethylene oxide in F-344 rat liver microsomes, lung microsomes, and lung cells. , 1989, Drug metabolism and disposition: the biological fate of chemicals.

[49]  G. Swaen,et al.  Mortality patterns among workers exposed to acrylamide. , 1989, Journal of occupational medicine. : official publication of the Industrial Medical Association.

[50]  Collins Jj,et al.  Mortality patterns among employees exposed to acrylonitrile. , 1989, Journal of occupational medicine. : official publication of the Industrial Medical Association.

[51]  W. Fayerweather,et al.  Mortality study of workers exposed to dimethylformamide and/or acrylonitrile. , 1988, Journal of occupational medicine. : official publication of the Industrial Medical Association.

[52]  W. Fayerweather,et al.  Cancer incidence of workers exposed to dimethylformamide and/or acrylonitrile. , 1988, Journal of occupational medicine. : official publication of the Industrial Medical Association.

[53]  T. Skopek,et al.  Mutagenicity of acrylonitrile and its metabolite 2-cyanoethylene oxide in human lymphoblasts in vitro. , 1988, Mutation research.

[54]  A. E. Roberts,et al.  Effect of glutathione depletion on the uptake of acrylonitrile vapors and on its irreversible association with tissue macromolecules. , 1988, Toxicology and applied pharmacology.

[55]  S. Szabó,et al.  Neoplasms in Rats Ingesting Acrylonitrile for Two Years , 1988 .

[56]  H. Savolainen,et al.  Consequences of acrylonitrile metabolism in rat hepatocytes: effects on lipid peroxidation and viability of the cells. , 1988, Environmental research.

[57]  D. K. Saxena,et al.  Testicular effects of acrylonitrile in mice. , 1988, Toxicology letters.

[58]  C. Maltoni,et al.  Long‐Term Carcinogenicity Bioassays on Acrylonitrile Administered by Inhalation and by Ingestion to Sprague‐Dawley Rats a , 1988, Annals of the New York Academy of Sciences.

[59]  R. Kraska,et al.  Acrylonitrile as a Carcinogen , 1988 .

[60]  R. Tardif,et al.  Urinary excretion of mercapturic acids and thiocyanate in rats exposed to acrylonitrile: influence of dose and route of administration. , 1987, Toxicology letters.

[61]  T. Shimada,et al.  SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: examination with 151 chemicals. , 1987, Mutation research.

[62]  J. Kopecký,et al.  2-Cyanoethylmercapturic acid (CEMA) in the urine as a possible indicator of exposure to acrylonitrile. , 1987, British journal of industrial medicine.

[63]  P. Working,et al.  Comparison of the dominant lethal effects of acrylonitrile and acrylamide in male Fischer 344 rats. , 1987, Mutagenesis.

[64]  S. Banerjee,et al.  In vitro transformation of C3H/10T1/2 and NIH/3T3 cells by acrylonitrile and acrylamide. , 1986, Cancer letters.

[65]  Guengerich Fp,et al.  In Vivo Interaction of Acrylonitrile and 2-Cyanoethylene Oxide with DNA in Rats , 1986 .

[66]  D. Bigner,et al.  Primary brain tumours in Fischer 344 rats chronically exposed to acrylonitrile in their drinking-water. , 1986, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[67]  M. O'berg,et al.  Epidemiologic study of workers exposed to acrylonitrile: an update. , 1985, Journal of occupational medicine. : official publication of the Industrial Medical Association.

[68]  J. Solomon,et al.  Direct alkylation of calf thymus DNA by acrylonitrile. Isolation of cyanoethyl adducts of guanine and thymine and carboxyethyl adducts of adenine and cytosine. , 1985, Environmental health perspectives.

[69]  P. Boor,et al.  Acrylonitrile-induced gastric mucosal necrosis: role of gastric glutathione. , 1985, The Journal of pharmacology and experimental therapeutics.

[70]  K. Decker,et al.  In vitro alkylation of calf thymus DNA by acrylonitrile. Isolation of cyanoethyl-adducts of guanine and thymine and carboxyethyl-adducts of adenine and cytosine. , 1984, Chemico-biological interactions.

[71]  M. Duverger-van Bogaert,et al.  Genotoxic properties of acrylonitrile. , 1984, Mutation research.

[72]  A. Buchter,et al.  Clinical toxicology of acrylonitrile. , 1984, Giornale italiano di medicina del lavoro.

[73]  R. Jaeger,et al.  Effects of acrylonitrile on tissue glutathione concentrations in rat, mouse, and hamster. , 1984, Research communications in chemical pathology and pharmacology.

[74]  M. Farooqui,et al.  The effects of acrylonitrile on hemoglobin and red cell metabolism. , 1983, Journal of toxicology and environmental health.

[75]  F. Guengerich,et al.  Metabolism of acrylonitrile by isolated rat hepatocytes. , 1983, Cancer research.

[76]  S. Bolognesi,et al.  Increase of sister chromatid exchange and unscheduled synthesis of deoxyribonucleic acid by acrylonitrile in human lymphocytes in vitro. , 1982, Scandinavian journal of work, environment & health.

[77]  G. Williams,et al.  Hepatocyte-mediated production of sister chromatid exchange in co-cultured cells by acrylonitrile: evidence for extra cellular transport of a stable reactive intermediate. , 1982, Cancer letters.

[78]  F. Poncelet,et al.  In vitro covalent binding of acrylonitrile to rat liver proteins. , 1982, Toxicology letters.

[79]  R. Monson,et al.  Mortality among rubber workers: VI. Men with potential exposure to acrylonitrile. , 1982, Journal of occupational medicine. : official publication of the Industrial Medical Association.

[80]  M. Hassan,et al.  Structural considerations in the metabolism of nitriles to cyanide in vivo. , 1982, Drug metabolism and disposition: the biological fate of chemicals.

[81]  S. Szabó,et al.  Possible role of lipid peroxidation in the actions of acrylonitrile on the adrenals, liver and gastrointestinal tract. , 1982, Research communications in chemical pathology and pharmacology.

[82]  Guengerich Fp,et al.  In Vitro Metabolism of Acrylonitrile to 2-Cyanoethylene Oxide, Reaction with Glutathione, and Irreversible Binding to Proteins and Nucleic Acids , 1981 .

[83]  A. Smith,et al.  Distinct Changes in the Expression TAZ are Associated with Normal Cervix and Human Cervical Cancer , 2018, Journal of Cancer.

[84]  J. B. Werner,et al.  Mortality of United Kingdom acrylonitrile polymerisation workers. , 1981, British journal of industrial medicine.

[85]  C. Willhite,et al.  Teratogenic effects of aliphatic nitriles. , 1981, Teratology.

[86]  C. Willhite,et al.  Morphogenesis of axial skeletal (dysraphic) disorders induced by aliphatic nitriles. , 1981, Teratology.

[87]  P. van Bladeren,et al.  Formation of mercapturic acids from acrylonitrile, crotononitrile, and cinnamonitrile by direct conjugation and via an intermediate oxidation process. , 1981, Drug metabolism and disposition: the biological fate of chemicals.

[88]  A. E. Ahmed,et al.  Acrylonitrile: in vivo metabolism in rats and mice. , 1981, Drug metabolism and disposition: the biological fate of chemicals.

[89]  B. Rollmann,et al.  Identification of two urinary metabolites of rats treated with acrylonitrile; influence of several inhibitors on the mutagenicity of those urines. , 1981, Toxicology letters.

[90]  V. Garny,et al.  Mutagenicity of acrylonitrile in mouse. , 1981, Toxicology letters.

[91]  A. E. Ahmed,et al.  Acrylonitrile: in vivo cytogenetic studies in mice and rats. , 1980, Mutation research.

[92]  和夫 橋本 アクリロニトリル(AN)の毒性 , 1980 .

[93]  M. O'berg Epidemiologic study of workers exposed to acrylonitrile. , 1980, Journal of occupational medicine. : official publication of the Industrial Medical Association.

[94]  J. Young,et al.  Identification of the major urinary metabolites of acrylonitrile in the rat. , 1980, Journal of toxicology and environmental health.

[95]  T. Zwingers,et al.  [Acrylonitrile--epidemiological study--Bayer 1977: a report on a prospective epidemiological study with a past beginning of coworkers at the Leverkusen plant of Bayer AG with acrylonitrile (ACN) exposure]. , 1979, Zentralblatt fur Arbeitsmedizin, Arbeitsschutz und Prophylaxe.

[96]  W. W. Nichols,et al.  Short-term tests for carcinogens and mutagens. , 1979, Mutation research.

[97]  K. Hemminki,et al.  Embryotoxicity of acrolein, acrylonitrile and acryl-amide in developing chick embryos , 1979 .

[98]  B. Casto,et al.  Effect of acrylonitrile on primary Syrian golden hamster embryo cells in culture: transformation and DNA fragmentation. , 1979, Journal of the National Cancer Institute.

[99]  B. Schwetz,et al.  Teratogenicity of acrylonitrile given to rats by gavage or by inhalation. , 1978, Food and cosmetics toxicology.

[100]  S. Venitt Mutagenic studies with acrylonitrile. , 1978, Mutation research.

[101]  E. Žuškin,et al.  Respiratory-function changes in textile workers exposed to synthetic fibers. , 1977, Archives of environmental health.

[102]  S. Venitt,et al.  Mutagenicity of acrylonitrile (cyanoethylene) in Escherichia coli. , 1977, Mutation research.

[103]  C. Maltoni,et al.  Carcinogenicity bioassays on rats of acrylonitrile administered by inhalation and by ingestion. , 1977, La Medicina del lavoro.

[104]  M. Wolff,et al.  Mutagenic studies with acrylonitrile. , 1977, Mutation research.

[105]  R. Sram,et al.  Mutagenic activity of some pesticides in Drosophila melanogaster. , 1968, IMS, Industrial medicine and surgery.

[106]  E. Spoerl,et al.  A SURVEY OF EFFECTS OF CHEMICALS ON DIVISION AND GROWTH OF YEAST AND ESCHERICHIA COLI , 1954, Journal of bacteriology.

[107]  H. Smith,et al.  COMPARATIVE EFFECTS OF CERTAIN CHEMICALS ON TRADESCANTIA CHROMOSOMES AS OBSERVED AT POLLEN TUBE MITOSIS , 1954 .

[108]  A. Loveless Qualitative Aspects of the Chemistry and Biology of Radiomimetic (Mutagenic) Substances , 1951, Nature.

[109]  T. Benn,et al.  Mortality of United Kingdom acrylonitrile workers--an extended and updated study. , 1998, Scandinavian journal of work, environment & health.

[110]  Esmen Na Exposure estimation in four major epidemiologic studies in the acrylonitrile industry. , 1998 .

[111]  R. Woutersen Toxicologic profile of acrylonitrile. , 1998, Scandinavian journal of work, environment & health.

[112]  P. Buffler,et al.  Mortality and morbidity of workers exposed to acrylonitrile in fiber production. , 1998, Scandinavian journal of work, environment & health.

[113]  J. Lubin,et al.  Mortality of industrial workers exposed to acrylonitrile. , 1998, Scandinavian journal of work, environment & health.

[114]  Makoto Hayashi,et al.  Evaluation of the rat micronucleus test with bone marrow and peripheral blood: Summary of the 9th collaborative study by CSGMT/JEMS·MMS , 1998, Environmental and molecular mutagenesis.

[115]  K. G. Darrall,et al.  Determination of benzene and associated volatile compounds in mainstream cigarette smoke. , 1998, The Analyst.

[116]  Collins Jj,et al.  Review and Meta-Analysis of Studies of Acrylonitrile Workers , 1998 .

[117]  N. Venkataprasad,et al.  Acrylonitrile Potentiates Oxidative Stress in Rat Alveolar Macrophages , 1997, Bulletin of environmental contamination and toxicology.

[118]  J. Rueff,et al.  Evaluation of some biomonitoring markers in occupationally exposed populations to acrylonitrile. , 1996, Teratogenesis, carcinogenesis, and mutagenesis.

[119]  J. M. Mason,et al.  Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. , 1994, Environmental and molecular mutagenesis.

[120]  T. Kawai,et al.  Biological monitoring of acrylonitrile exposure through a new analytical approach to hemoglobin and plasma protein adducts and urinary metabolites in rats and humans , 1993, International archives of occupational and environmental health.

[121]  M. Nivard,et al.  Performance of 181 chemicals in a Drosophila assay predominantly monitoring interchromosomal mitotic recombination. , 1993, Mutagenesis.

[122]  G. Mastrangelo,et al.  Mortality from tumours in workers in an acrylic fibre factory. , 1993, Occupational medicine.

[123]  P. Working,et al.  Tissue‐specific genotoxic effects of acrylamide and acrylonitrile , 1992, Environmental and molecular mutagenesis.

[124]  T. Muto,et al.  Health profiles of workers exposed to acrylonitrile. , 1992, The Keio journal of medicine.

[125]  K. Omae,et al.  Effect of chronic exposure to acrylonitrile on subjective symptoms. , 1992, The Keio journal of medicine.

[126]  A. Sehgal,et al.  Aneuploidy in drosophila. III: Aneuploidogens inhibit in vitro assembly of taxol‐purified drosophila microtubules , 1990, Environmental and molecular mutagenesis.

[127]  M. Nosko,et al.  [Changes in the liver function of workers exposed to petroleum products]. , 1989, Problemi na khigienata.

[128]  M. O'berg,et al.  Cancer incidence and mortality among workers exposed to acrylonitrile. , 1987, American journal of industrial medicine.

[129]  Guengerich Fp,et al.  Metabolism and covalent binding of vic-dihaloalkanes, vinyl halides and acrylonitrile. , 1986 .

[130]  A. Stead,et al.  Sister chromatid exchange and chromosome aberration analyses in mice after in vivo exposure to acrylonitrile, styrene, or butadiene monoxide. , 1986, Environmental mutagenesis.

[131]  D. Anderson,et al.  Suitability of the P388F mouse lymphoma system for detecting potential carcinogens and mutagens. , 1985, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[132]  B. Rollmann,et al.  Metabolism and mutagenicity of acrylonitrile: an in vivo study. , 1985, Environmental mutagenesis.

[133]  A. E. Ahmed,et al.  Effect of acute acrylonitrile exposure on metrazol induced seizures in the rat. , 1985, Neurotoxicology.

[134]  H. Bolt,et al.  Irreversible binding of acrylonitrile to nucleic acids. , 1983, Xenobiotica; the fate of foreign compounds in biological systems.

[135]  A. E. Ahmed,et al.  Distribution and covalent interactions of [1-14C]acrylonitrile in the rat. , 1982, Toxicology.

[136]  A. Sapota The disposition of [14C]acrylonitrile in rats. , 1982, Xenobiotica; the fate of foreign compounds in biological systems.

[137]  J. Kopecký,et al.  Mutagenic Activity of Oxiranecarbonitrile (Glycidonitrile) , 1981 .

[138]  W. Lijinsky,et al.  Mutagenicity of vinyl compounds in Salmonella typhimurium. , 1980, Teratogenesis, carcinogenesis, and mutagenesis.

[139]  T. Heinonen,et al.  Decrease of reduced glutathione in isolated rat hepatocytes caused by acrolein, acrylonitrile, and the thermal degradation products of styrene copolymers. , 1980, Toxicology.

[140]  M. Bogaert,et al.  Mutagenicity of urine from rats and mice treated with acrylonitrile. , 1980, Toxicology.

[141]  M. Roberfroid,et al.  Liver extract mediated mutagenicity of acrylonitrile. , 1979, Toxicology.

[142]  M. Roberfroid,et al.  Mutagenicity of acrylonitrile. , 1978, Toxicology.