Type I diabetes mellitus. A chronic autoimmune disease.

DURING the past decade a wealth of information concerning the pathogenesis of Type I diabetes has become available. Two spontaneous animal models of the disease have been discovered and characterized (the Biobreeding rat and the non-obese diabetic mouse); the importance of a gene or genes in the major histocompatibility complex in Type I diabetes of human beings, of mice, and of rats has been appreciated; and the prognostic importance of selected assays for islet-cell antibodies has been defined. T-cell abnormalities that precede diabetes have been discovered. Evidence has suggested that progressive loss of first-phase insulin secretion precedes diabetes, and immunologic . . .

[1]  M. Dorf,et al.  The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. , 1986, Science.

[2]  G. Eisenbarth,et al.  First-degree relatives of patients with type I diabetes mellitus. Islet-cell antibodies and abnormal insulin secretion. , 1985, The New England journal of medicine.

[3]  D. R. Gamble,et al.  In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. , 1985, The New England journal of medicine.

[4]  J. Nerup,et al.  Cytokines Cause Functional and Structural Damage to Isolated Islets of Langerhans , 1985, Allergy.

[5]  J. Seidman,et al.  Major histocompatibility complex restriction fragment length polymorphisms define three diabetogenic haplotypes in BB and BBN rats , 1985, The Journal of experimental medicine.

[6]  R. Dluhy,et al.  Ia-positive T lymphocytes in recently diagnosed idiopathic Addison's disease. , 1984, The American journal of medicine.

[7]  B. Myers,et al.  Cyclosporine-associated chronic nephropathy. , 1984, The New England journal of medicine.

[8]  B. Haynes,et al.  Ia+ T cells in new onset Graves' disease. , 1984, The Journal of clinical endocrinology and metabolism.

[9]  N. Maclaren,et al.  ISLET-CELL ANTIBODIES ARE SELDOM TRANSIENT , 1984, The Lancet.

[10]  R. Akeson,et al.  Characterization of monoclonal antibody 3G5 and utilization of this antibody to immobilize pancreatic islet cell gangliosides in a solid phase radioassay. , 1984, Endocrinology.

[11]  A. Laupacis,et al.  Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset. , 1984, Science.

[12]  T. Starzl,et al.  REVERSIBILITY OF LYMPHOMAS AND LYMPHOPROLIFERATIVE LESIONS DEVELOPING UNDER CYCLOSPORIN-STEROID THERAPY , 1984, The Lancet.

[13]  J. Dausset,et al.  Class II HLA-DC beta-chain DNA restriction fragments differentiate among HLA-DR2 individuals in insulin-dependent diabetes and multiple sclerosis. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[14]  B. Trapp,et al.  IgM in a human neuropathy related to paraproteinemia binds to a carbohydrate determinant in the myelin-associated glycoprotein and to a ganglioside. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[15]  J. Palmer,et al.  Insulin antibodies in insulin-dependent diabetics before insulin treatment. , 1983, Science.

[16]  Å. Lernmark,et al.  Inhibition of insulin release after passive transfer of immunoglobulin from insulin-dependent diabetic children to mice. , 1983, The Journal of clinical endocrinology and metabolism.

[17]  L. Chiovato,et al.  Lectin-induced expression of DR antigen on human cultured follicular thyroid cells , 1983, Nature.

[18]  P. A. Peterson,et al.  HLA-D region β-chain DNA endonuclease fragments differ between HLA-DR identical healthy and insulin-dependent diabetic individuals , 1983, Nature.

[19]  W. Chick,et al.  Passive transfer of diabetes in the BB/W rat. , 1983, Science.

[20]  N. Gregson,et al.  IgM paraproteins with immunological specificity for a Schwann cell component and peripheral nerve myelin in patients with polyneuropathy , 1983, Journal of the Neurological Sciences.

[21]  J. Mordes,et al.  Transfusions of whole blood prevent spontaneous diabetes mellitus in the BB/W rat. , 1983, Science.

[22]  G. Eisenbarth,et al.  Islet-cell antibodies and beta-cell function in monozygotic triplets and twins initially discordant for Type I diabetes mellitus. , 1983, The New England journal of medicine.

[23]  D. Pyke,et al.  HLA-DR typing in identical twins with insulin-dependent diabetes: difference between concordant and discordant pairs. , 1983, British medical journal.

[24]  Å. Lernmark,et al.  Plasmapheresis in the initial treatment of insulin-dependent diabetes mellitus in children. , 1983, British medical journal.

[25]  E. Yunis,et al.  Extended HLA/complement allele haplotypes: evidence for T/t-like complex in man. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[26]  H. Birgens,et al.  Identification of a cold agglutinin with anti-Pr3 specificity. , 2009, Scandinavian journal of haematology.

[27]  T. Waldmann,et al.  A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor , 1982, Nature.

[28]  P. Vitti,et al.  Monoclonal antibodies to the thyrotropin receptor: stimulating and blocking antibodies derived from the lymphocytes of patients with Graves disease. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[29]  G. Eisenbarth,et al.  Expression of receptors for tetanus toxin and monoclonal antibody A2B5 by pancreatic islet cells. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[30]  S. Baekkeskov,et al.  Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins , 1982, Nature.

[31]  S. Gupta,et al.  Deficiency of suppressor T-cells in insulin-dependent diabetes mellitus: an analysis with monoclonal antibodies. , 1982, Immunology letters.

[32]  B. Haynes,et al.  Increased circulating Ia-antigen-bearing T cells in type I diabetes mellitus. , 1982, The New England journal of medicine.

[33]  J. McNally,et al.  EVIDENCE FOR A LONG PREDIABETIC PERIOD IN TYPE I (INSULIN-DEPENDENT) DIABETES MELLITUS , 1981, The Lancet.

[34]  T. Seemayer,et al.  Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex , 1981, The Journal of experimental medicine.

[35]  W. Silvers,et al.  Prevention of Diabetes in Rats by Bone Marrow Transplantation , 1981, Annals of surgery.

[36]  J. Shelhamer,et al.  Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes. , 1981, Journal of immunology.

[37]  R. Scearce,et al.  Cytotoxic antibodies to cloned rat islet cells in serum of patients with diabetes mellitus. , 1981, The Journal of clinical investigation.

[38]  F. Ginsberg-Fellner,et al.  Cytotoxic autoantibodies to beta cells in the serum of patients with insulin-dependent diabetes mellitus. , 1980, The New England journal of medicine.

[39]  M. Molitch,et al.  HLA factors in non-insulin-dependent diabetes mellitus. , 1980 .

[40]  T. Onodera,et al.  Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. , 1979, The New England journal of medicine.

[41]  Å. Lernmark,et al.  Islet-cell-surface antibodies in juvenile diabetes mellitus. , 1978, The New England journal of medicine.

[42]  T. Strom,et al.  Specific insulin binding site on T and B lymphocytes as a marker of cell activation , 1978, Nature.

[43]  E. Marliss,et al.  The spontaneously diabetic Wistar rat (the "BB" rat). Studies prior to and during development of the overt syndrome. , 1978, Diabetologia.

[44]  W. Irvine.  CLASSIFICATION OF DIABETES MELLITUS , 1977, The Lancet.

[45]  W. Irvine,et al.  PANCREATIC ISLET-CELL ANTIBODY AS A MARKER FOR ASYMPTOMATIC AND LATENT DIABETES AND PREDIABETES , 1976, The Lancet.

[46]  E. Barnes,et al.  Antibodies to pancreatic islet cells in insulin-dependent diabetics with coexistent autoimmune disease. , 1974, Lancet.

[47]  D. Doniach,et al.  Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. , 1974, Lancet.

[48]  J. Neel.  The genetics of diabetes mellitus. , 1970, Advances in metabolic disorders.

[49]  Attwater Hl.  Surgery of urethral stricture. , 1948 .