A geometric approach to characterize rigidity in proteins

Kinematic analysis, in contrast to sophisticated molecular dynamics simulations, can provide high-level insights into conformational diversity of proteins and other biomolecules, with broad implications for human health. Here, we model a protein as a kinematic linkage and present a new geometric method to characterize molecular rigidity. While existing combinatorial constraint counting is limited to generic structures, our geometric approach is also valid for non-generic linkages. (© 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)

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