Reduced proliferation of non-megakaryocytic acute myelogenous leukemia and other leukemia and lymphoma cell lines in response to eltrombopag.

[1]  M. Kawahara,et al.  Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome. , 2009, Blood.

[2]  J. Bussel,et al.  Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial , 2009, The Lancet.

[3]  J. Luengo,et al.  Preclinical Activity of Eltrombopag (SB-497115), an Oral, Nonpeptide Thrombopoietin Receptor Agonist , 2009, Stem cells.

[4]  O. Frankfurt,et al.  Growth Factors in Acute Myeloid Leukemia , 2009 .

[5]  E. Morselli,et al.  Control of autophagy by oncogenes and tumor suppressor genes , 2009, Cell Death and Differentiation.

[6]  Randall W. King,et al.  A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion , 2007, Cell.

[7]  J. Bussel,et al.  Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. , 2007, The New England journal of medicine.

[8]  T. Berg,et al.  Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. , 2007, The New England journal of medicine.

[9]  R. Larson,et al.  Phase 1/2 Study of AMG 531 in Thrombocytopenic Patients (pts) with Low-Risk Myelodysplastic Syndrome (MDS): Update Including Extended Treatment. , 2007 .

[10]  E. Estey,et al.  Establishment of baseline toxicity expectations with standard frontline chemotherapy in acute myelogenous leukemia. , 2007, Blood.

[11]  C. Erickson-Miller,et al.  Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. , 2007, Blood.

[12]  H. Kantarjian,et al.  The incidence and impact of thrombocytopenia in myelodysplastic syndromes , 2007, Cancer.

[13]  K. Duffy,et al.  THE DISCOVERY OF ELTROMBOPAG, AN ORALLY BIOAVAILABLE TpoR AGONIST , 2007 .

[14]  Robert A Blake,et al.  Target validation in drug discovery. , 2007, Methods in molecular biology.

[15]  E. Estey Growth factors in acute myeloid leukaemia. , 2001, Best practice & research. Clinical haematology.

[16]  S. Seeber,et al.  Analysis of thrombopoietin receptor (c-mpl) mRNA expression in de novo acute myeloid leukemia. , 2000, Leukemia research.

[17]  T. Miyamoto,et al.  Effect of Thrombopoietin on Acute Myelogenous Leukemia Blasts , 2000, Leukemia & lymphoma.

[18]  M. R. Ricciardi,et al.  Thrombopoietin, Interleukin-11, and Early-Acting Megakaryocyte Growth Factors in Human Myeloid Leukemia Cells , 2000, Leukemia & lymphoma.

[19]  K. Chihara,et al.  Proliferative reaction of myelogenous leukemia cells with cytokines G-CSF, GM-CSF, M-CSF, SCF and TPO. , 1998, Leukemia research.

[20]  R. Ohno,et al.  Quantitative expression of thrombopoietin receptor on leukaemia cells from patients with acute myeloid leukaemia and acute lymphoblastic leukaemia , 1998, British journal of haematology.

[21]  M. Brereton,et al.  The in vitro effect of pegylated recombinant human megakaryocyte growth and development factor (PEG rHuMGDF) on megakaryopoiesis in normal subjects and patients with myelodysplasia and acute myeloid leukaemia , 1997, British journal of haematology.

[22]  H. Hirai,et al.  Effects of thrombopoietin (c‐mpl ligand) on growth of blast cells from patients with transient abnormal myelopoiesis and acute myeloblastic leukemia , 1997, European journal of haematology.

[23]  C. Bloomfield,et al.  Expression of c-mpl mRNA, the receptor for thrombopoietin, in acute myeloid leukemia blasts identifies a group of patients with poor response to intensive chemotherapy. , 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[24]  W. Piacibello,et al.  Megakaryocyte growth and development factor (MGDF)-induced acute leukemia cell proliferation and clonal growth is associated with functional c-mpl , 1997, Leukemia.

[25]  H. Mizoguchi,et al.  Growth stimulatory effect of thrombopoietin on the blast cells of acute myelogenous leukaemia , 1996, British journal of haematology.

[26]  H. Drexler,et al.  Expression of the receptor MPL and proliferative effects of its ligand thrombopoietin on human leukemia cells. , 1996, Leukemia.

[27]  I. Matsumura,et al.  Growth response of acute myeloblastic leukemia cells to recombinant human thrombopoietin. , 1995, Blood.

[28]  V. Ribrag,et al.  Expression of the c-mpl proto-oncogene in human hematologic malignancies. , 1993, Blood.

[29]  H. Gralnick,et al.  Proposals for the classification of the myelodysplastic syndromes , 1982, British journal of haematology.