Antimicrobial Peptides of Multicellular Organisms: My Perspective.

Antimicrobial peptides of multicellular organisms were first characterized in the 1980s by investigators who felt that known systems of immunity could not explain what they observed: the resistance to bacterial infection of a Cecropia moth pupa lacking antibodies or lymphocytes (cecropins (Steiner 1981)), the potent microbicidal activity of neutrophils from a rabbit (defensins (Selsted et al. 1985)), and the healing of a wound on the skin of the African clawed frog without infection in a non-sterile aquarium (magainins (Zasloff 1987)). Since then AMPs have been discovered in diverse species of fungi, plants, and animals (Seshadri Sundararajan et al. 2012; Fan et al. 2016; Waghu et al. 2016; Wang et al. 2016). It is likely that we will discover that every multicellular organism expresses antimicrobial peptides as a key element of their immune system. Why are antimicrobial peptides so popular in Nature?

[1]  K. Brogden.  Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? , 2005, Nature Reviews Microbiology.

[2]  M. Selsted,et al.  Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils. , 1985, The Journal of biological chemistry.

[3]  C. B. Park,et al.  Structure-activity analysis of buforin II, a histone H2A-derived antimicrobial peptide: the proline hinge is responsible for the cell-penetrating ability of buforin II. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[4]  Hanmei Xu,et al.  DRAMP: a comprehensive data repository of antimicrobial peptides , 2016, Scientific Reports.

[5]  Vladimir B. Bajic,et al.  DAMPD: a manually curated antimicrobial peptide database , 2011, Nucleic Acids Res..

[6]  M. Welsh,et al.  Reduced Airway Surface pH Impairs Bacterial Killing in the Porcine Cystic Fibrosis Lung , 2012, Nature.

[7]  B. Thomma,et al.  Defensins from Insects and Plants Interact with Fungal Glucosylceramides* , 2004, Journal of Biological Chemistry.

[8]  T. Golde,et al.  Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21 , 2005, Nature Immunology.

[9]  Xia Li,et al.  APD3: the antimicrobial peptide database as a tool for research and education , 2015, Nucleic Acids Res..

[10]  T. Wassenaar,et al.  A secreted antibacterial neuropeptide shapes the microbiome of Hydra , 2017, Nature Communications.

[11]  M. Zasloff.  Antimicrobial peptides of multicellular organisms , 2002, Nature.

[12]  M. Zasloff,et al.  The nervous system and innate immunity: the neuropeptide connection. , 2005, Nature immunology.

[13]  M. Zasloff,et al.  Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor , 1987 .

[14]  Faiza Hanif Waghu,et al.  CAMPR3: a database on sequences, structures and signatures of antimicrobial peptides , 2015, Nucleic Acids Res..

[15]  D. Hultmark,et al.  Sequence and specificity of two antibacterial proteins involved in insect immunity , 1981, Nature.

[16]  M. Weichenthal,et al.  Reduced Paneth cell α-defensins in ileal Crohn's disease , 2005 .

[17]  Søren Neve,et al.  Plectasin, a Fungal Defensin, Targets the Bacterial Cell Wall Precursor Lipid II , 2010, Science.