Analysis of pathogenesis of juvenile new‐onset diabetes

Background:  Measurement of anti‐islet autoantibodies at the time of disease onset contributes greatly to the differentiation of Type 1A diabetes with HLA Class II subtyping also contributing.

[1]  Dana Dabelea,et al.  Incidence of diabetes in youth in the United States. , 2007, JAMA.

[2]  T. Wilkin,et al.  Increasing body weight predicts the earlier onset of insulin‐dependant diabetes in childhood: testing the ‘accelerator hypothesis’ (2) , 2005, Diabetic medicine : a journal of the British Diabetic Association.

[3]  T. Jones,et al.  Increase in type 2 diabetes in children and adolescents in Western Australia , 2004, The Medical journal of Australia.

[4]  T. Waldhör,et al.  Type 2 diabetes mellitus is rare but not absent in children under 15 years of age in Austria , 2003, European Journal of Pediatrics.

[5]  M. A. Kelly,et al.  Molecular aspects of type 1 diabetes , 2003, Molecular pathology : MP.

[6]  M. A. Kelly,et al.  Sequencing of the Second Exon of the MHC Class II DQ6 Alleles in Patients with Type 1 Diabetes , 2002, Autoimmunity.

[7]  E. Thorsby,et al.  DR- and DQ-associated protection from type 1A diabetes: comparison of DRB1*1401 and DQA1*0102-DQB1*0602*. , 2000, The Journal of clinical endocrinology and metabolism.

[8]  L. V. Van Gaal,et al.  High frequency of persisting or increasing islet-specific autoantibody levels after diagnosis of type 1 diabetes presenting before 40 years of age. The Belgian Diabetes Registry. , 2000, Diabetes care.

[9]  H J Dean,et al.  Childhood obesity in a population at high risk for type 2 diabetes. , 2000, The Journal of pediatrics.

[10]  G. Eisenbarth,et al.  Islet cell antibody-positive relatives with human leukocyte antigen DQA1*0102, DQB1*0602: identification by the Diabetes Prevention Trial-type 1. , 2000, The Journal of clinical endocrinology and metabolism.

[11]  M. Rewers,et al.  Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[12]  N. Maclaren,et al.  Autoimmunity and diabetes. , 1999, The Journal of clinical endocrinology and metabolism.

[13]  P. Raskin,et al.  Report of the expert committee on the diagnosis and classification of diabetes mellitus. , 1999, Diabetes care.

[14]  P. Zimmet,et al.  Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation , 1998, Diabetic medicine : a journal of the British Diabetic Association.

[15]  J. Widimský,et al.  Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus , 1998, Diabetes Care.

[16]  P. Bingley,et al.  Prediction of IDDM in the General Population: Strategies Based on Combinations of Autoantibody Markers , 1997, Diabetes.

[17]  M. Rewers,et al.  Antiislet autoantibodies usually develop sequentially rather than simultaneously. , 1996, The Journal of clinical endocrinology and metabolism.

[18]  M. Rewers,et al.  Newborn screening for HLA markers associated with IDDM: Diabetes Autoimmunity Study in the Young (DAISY) , 1996, Diabetologia.

[19]  H. Erlich,et al.  HLA-DQB1*0602 Is Associated With Dominant Protection From Diabetes Even Among Islet Cell Antibody–Positive First-Degree Relatives of Patients with IDDM , 1995, Diabetes.

[20]  Å. Lernmark,et al.  Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. , 1995, The Journal of clinical investigation.

[21]  J. Krischer,et al.  Islet cell antibodies predict insulin-dependent diabetes in United States school age children as powerfully as in unaffected relatives. , 1994, The Journal of clinical investigation.

[22]  J. Krischer,et al.  High frequency of abnormal glucose tolerance in DQA1*0102/DQB1*0602 relatives identified as part of the Diabetes Prevention Trial—Type 1 Diabetes , 2004, Diabetologia.

[23]  R. Buzzetti,et al.  Autoantibody negative new onset Type 1 diabetic patients lacking high risk HLA alleles in a Caucasian population: are these Type 1b diabetes cases? , 2000, Diabetes/metabolism research and reviews.