Resonant Photonic Biosensors with Polarization-Based Multiparametric Discrimination in Each Channel

In this paper, we describe guided-mode resonance biochemical sensor technology. We briefly discuss sensor fabrication and show measured binding dynamics for example biomaterials in use in our laboratories. We then turn our attention to a particularly powerful attribute of this technology not possessed by competing methods. This attribute is the facile generation of multiple resonance peaks at an identical physical location on the sensor surface. These peaks respond uniquely to the biomolecular event, thereby enriching the data set available for event quantification. The peaks result from individual, polarization-dependent resonant leaky modes that are the foundation of this technology. Thus, by modeling the binding event and fitting to a rigorous electromagnetic formalism, we can determine individual attributes of the biolayer and its surroundings and avoid a separate reference site for background monitoring. Examples provide dual-polarization quantification of biotin binding to a silane-coated sensor as well as binding of the cancer biomarker protein calreticulin to its monoclonal IgG capture antibody. Finally, we present dual-polarization resonance response for poly (allylamine hydrochloride) binding to the sensor with corresponding results of backfitting to a simple model; this differentiates the contributions from biolayer adhesion and background changes.

[1]  T. Gaylord,et al.  Analysis and applications of optical diffraction by gratings , 1985, Proceedings of the IEEE.

[2]  Evgeny Popov,et al.  Zero order anomaly of dielectric coated gratings , 1985 .

[3]  H. Raether.  Surface Plasmons on Smooth and Rough Surfaces and on Gratings , 1988 .

[4]  Ivan Avrutsky,et al.  Interference Phenomena in Waveguides with Two Corrugated Boundaries , 1989 .

[5]  Michael T. Gale,et al.  Zero-order diffractive microstructures for security applications , 1990, Photonics West - Lasers and Applications in Science and Engineering.

[6]  R. Magnusson,et al.  New principle for optical filters , 1992 .

[7]  S. S. Wang,et al.  Theory and applications of guided-mode resonance filters. , 1993, Applied optics.

[8]  A A Friesem,et al.  Light modulation with resonant grating-waveguide structures. , 1996, Optics letters.

[9]  S. Peng,et al.  Experimental demonstration of resonant anomalies in diffraction from two-dimensional gratings. , 1996, Optics letters.

[10]  F. Caruso,et al.  2. Assembly of Alternating Polyelectrolyte and Protein Multilayer Films for Immunosensing , 1997 .

[11]  A. Friesem,et al.  Resonant grating waveguide structures , 1997 .

[12]  Theodor Tamir,et al.  Resonant scattering by multilayered dielectric gratings , 1997 .

[13]  T K Gaylord,et al.  Normal-incidence guided-mode resonant grating filters: design and experimental demonstration. , 1998, Optics letters.

[14]  G. M. Morris,et al.  Experimental investigation of resonant-grating filter lineshapes in comparison with theoretical models , 1998 .

[15]  Robert H. Austin,et al.  Introduction to Bioanalytical Sensors , 1998 .

[16]  Sorin Tibuleac,et al.  Thin-film optical filters with diffractive elements and waveguides , 1998 .

[17]  T. J. McCarthy,et al.  Stepwise Polymer Surface Modification: ChemistryLayer-by-Layer Deposition , 1998 .

[18]  S Tibuleac,et al.  High-efficiency guided-mode resonance filter. , 1998, Optics letters.

[19]  Z. S. Liu,et al.  Guided-mode resonance Brewster filter. , 1998, Optics letters.

[20]  S. Tibuleac,et al.  Resonant diffractive structures integrating waveguide-gratings on optical fiber endfaces , 1999, 1999 IEEE LEOS Annual Meeting Conference Proceedings. LEOS'99. 12th Annual Meeting. IEEE Lasers and Electro-Optics Society 1999 Annual Meeting (Cat. No.99CH37009).

[21]  W. Stafford,et al.  Probing the three-dimensional structure of human calreticulin. , 2000, Biochemistry.

[22]  Robert Magnusson,et al.  Optical fiber endface biosensor based on resonances in dielectric waveguide gratings , 2000, Photonics West - Biomedical Optics.

[23]  Koichi Iwata,et al.  Refractive index sensor with a guided-mode resonant grating filter , 2001, Optical Engineering for Sensing and Nanotechnology.

[24]  B. Cunningham,et al.  A plastic colorimetric resonant optical biosensor for multiparallel detection of label-free biochemical interactions , 2002, Proceedings of IEEE Sensors.

[25]  B. Cunningham,et al.  Colorimetric resonant reflection as a direct biochemical assay technique , 2002, Technical Digest. MEMS 2002 IEEE International Conference. Fifteenth IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.02CH37266).

[26]  J. Homola.  Present and future of surface plasmon resonance biosensors , 2003, Analytical and bioanalytical chemistry.

[27]  Robert Magnusson,et al.  Photonic devices enabled by waveguide-mode resonance effects in periodically modulated films , 2003, SPIE Optics + Photonics.

[28]  Robert Magnusson,et al.  Use of nondegenerate resonant leaky modes to fashion diverse optical spectra. , 2004, Optics express.

[29]  Robert Magnusson,et al.  Resonating periodic waveguides as ultraresolution sensors in biomedicine , 2004, SPIE Optics + Photonics.

[30]  R. Magnusson,et al.  Resonant leaky-mode spectral-band engineering and device applications. , 2004, Optics express.

[31]  F. Liu,et al.  Resonant grating filters as refractive index sensors for chemical and biological detections , 2005 .

[32]  Emanuel F Petricoin,et al.  Importance of communication between producers and consumers of publicly available experimental data. , 2005, Journal of the National Cancer Institute.

[33]  Robert Magnusson,et al.  Characteristics of resonant leaky-mode biosensors , 2005, SPIE Optics East.

[34]  Ye Fang,et al.  Probing cytoskeleton modulation by optical biosensors , 2005, FEBS letters.

[35]  Sorin Tibuleac,et al.  Optical Waveguide-mode Resonant Biosensors , 2006 .

[36]  Mark E. Cooper.  Current biosensor technologies in drug discovery , 2006 .

[37]  Elisa Rossi,et al.  Gene expression profile of ovarian serous papillary carcinomas: identification of metastasis-associated genes. , 2007, American journal of obstetrics and gynecology.

[38]  Ye Fang,et al.  Label-free cell-based assays for GPCR screening. , 2008, Combinatorial chemistry & high throughput screening.

[39]  Ibrahim Abdulhalim,et al.  Biosensing Configurations Using Guided Wave Resonant Structures , 2008 .

[40]  Hikmat N. Daghestani,et al.  Theory and Applications of Surface Plasmon Resonance, Resonant Mirror, Resonant Waveguide Grating, and Dual Polarization Interferometry Biosensors , 2010, Sensors.

[41]  Robert Magnusson,et al.  Guided-mode resonance sensor system for early detection of ovarian cancer , 2010, BiOS.