Arterial stiffness and the development of hypertension

Evidence is accumulating in support of the plausible notion that lower arterial elasticity is associated with an increased risk of cardiovascular disease manifestations. Conventional indices of arterial stiffness are compared to a newer method (blood pressure-adjusted pulsatile arterial diameter change) in terms of blood pressure dependence. Impaired elasticity of larger arteries is an antecedent factor in the natural history of blood pressure elevation at the population level. Strong evidence supports the notion that lower arterial elasticity in the medium-sized arteries is associated with the development of hypertension.

[1]  F. Cambien,et al.  Influence of angiotensin-converting enzyme and angiotensin II type 1 receptor gene polymorphisms on aortic stiffness in normotensive and hypertensive patients. , 1996, Circulation.

[2]  E. Lakatta,et al.  Another Modifiable Risk Factor for Cardiovascular Disease? Some Evidence Points to Arterial Stiffness , 1995, Journal of the American Geriatrics Society.

[3]  V. Dzau.  Cell biology and genetics of angiotensin in cardiovascular disease , 1994, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

[4]  R W Barnes,et al.  Ultrasonic Measurement of the Elastic Modulus of the Common Carotid Artery The Atherosclerosis Risk in Communities ( ARIC ) Study , 2005 .

[5]  V. Salomaa,et al.  Non-insulin-dependent diabetes mellitus and fasting glucose and insulin concentrations are associated with arterial stiffness indexes. The ARIC Study. Atherosclerosis Risk in Communities Study. , 1995, Circulation.

[6]  Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group. , 1991, JAMA.

[7]  L. Chambless,et al.  Arterial stiffness and the development of hypertension. The ARIC study. , 1999, Hypertension.

[8]  M. Safar,et al.  Aortic collagen, aortic stiffness, and AT1 receptors in experimental and human hypertension. , 1996, Canadian journal of physiology and pharmacology.

[9]  H G SCHEIE,et al.  Evaluation of ophthalmoscopic changes of hypertension and arteriolar sclerosis. , 1953, A.M.A. archives of ophthalmology.

[10]  R. C. Hansoti.  Arterial pulse in health and disease. , 1961, Indian journal of medical sciences.

[11]  W. Riley,et al.  Arterial stiffness: a new cardiovascular risk factor? , 1994, American journal of epidemiology.