Smallpox and the Native American

&NA; With the arrival of Europeans in the Western Hemisphere, Native American populations were exposed to new infectious diseases, diseases for which they lacked immunity. These communicable diseases, including smallpox and measles, devastated entire native populations. In this article, we focus on the effect of smallpox on the Native Americans from the 15th through the 19th centuries. Among the “new” infectious diseases brought by the Europeans, smallpox was one of the most feared because of the high mortality rates in infected Native Americans. This fear may have been well‐founded, because the Native Americans were victims of what was probably one of the earliest episodes of biological warfare. Fortunately, they were also major beneficiaries of early vaccination programs. Thus, the arrival of smallpox and the decline of the Native American populations are inexorably linked, as the history summarized here illustrates.

[1]  A. E. Stearn,et al.  The Effect of Smallpox on the Destiny of the Amerindian , 1946 .

[2]  F. Fenner.  Smallpox and its eradication , 1988 .

[3]  H. Simpson.  The impact of disease on American history. , 1954, The New England journal of medicine.

[4]  A. Macnalty.  A History of Immunization , 1965, Medical History.

[5]  John E. Bennett,et al.  Principles and practice of infectious diseases. Vols 1 and 2. , 1979 .

[6]  G. E. Smith.  The Negro in the New World , 1910, Nature.

[7]  M. Ravenel.  How the President, Thomas Jefferson, and Doctor Benjamin Waterhouse Established Vaccination at a Public Health Procedure , 1937 .

[8]  F. H. Garrison.  Four Centuries of Medical History in Canada, and a Sketch of the Medical History of Newfoundland , 1930 .

[9]  F. Fenner.  Smallpox, “the most dreadful scourge of the human species” , 1984, The Medical journal of Australia.

[10]  H. Zinsser,et al.  How the President, Thomas Jefferson, and Doctor Benjamin Waterhouse Established Vaccination as a Public Health Procedure , 1936 .

[11]  R. Maulitz,et al.  The Cambridge World History of Human Disease , 1993 .

[12]  W. Wanklyn.  How TO Diagnose Smallpox , 1914 .

[13]  Francis Parkman,et al.  The conspiracy of Pontiac , 1908 .

[14]  K. Warren,et al.  Algorithms in the diagnosis and management of exotic diseases. XIX. Major tropical viral infections: smallpox, yellow fever, and Lassa fever. , 1977, The Journal of infectious diseases.

[15]  J. J. Heagerty.  Four Centuries of Medical History in Canada and a Sketch of the Medical History of Newfoundland, Vol. 2 , 2017 .

[16]  Frost Rh.  The Pueblo Indian smallpox epidemic in New Mexico, 1898-1899. , 1990 .

[17]  L. Wilkinson.  Jenner's smallpox vaccine. The riddle of vaccinia virus and its origin , 1982, Medical History.

[18]  J. B. Blake,et al.  Epidemics in Colonial America , 1953, The Yale Journal of Biology and Medicine.

[19]  G. H. Smith.  A Brief Rule to Guide the Common People of New-England How to Order Themselves and Theirs in the Small Pocks, or Measles , 1938, The Yale Journal of Biology and Medicine.

[20]  Kugel Rb.  The University of Kansas Medical Center. , 1977 .

[21]  R. Frost.  The Pueblo Indian smallpox epidemic in New Mexico, 1898-1899. , 1990, Bulletin of the history of medicine.