论文信息 - Liquid handling using expandable microspheres

Liquid handling using expandable microspheres

In this study we introduce two novel concepts for fluid handling in microfluidic systems and show their realization in micromachined test structures: a one-shot micropump and a normally open one-shot valve. Both principles use Expancel/spl reg/ microspheres, which are small spherical plastic particles that, when heated, increase their volume by a factor of about 60. The expansion is irreversible, i.e. when cooled again, the expandable microspheres do not shrink.

[1] Robin H. Liu,et al. Functional hydrogel structures for autonomous flow control inside microfluidic channels , 2000, Nature.

[2] R. Pethig,et al. Applications of dielectrophoresis in biotechnology. , 1997, Trends in biotechnology.

[3] M. Madou,et al. Microactuators toward microvalves for responsive controlled drug delivery , 2000 .

[4] S. Jacobson,et al. High-Speed Separations on a Microchip , 1994 .

[5] O. Guenat,et al. Partial electroosmotic pumping in complex capillary systems: Part 1: Principles and general theoretical approach , 2001 .

[6] R Langer,et al. Microchips as Controlled Drug-Delivery Devices. , 2000, Angewandte Chemie.

[7] Peter Enoksson,et al. A Valve-Less Diffuser Micropump for Microfluidic Analytical Systems , 2001 .

[8] S. Quake,et al. Monolithic microfabricated valves and pumps by multilayer soft lithography. , 2000, Science.

[9] D. J. Harrison,et al. Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip , 1993, Science.

[10] Masayoshi Esashi,et al. Microflow devices and systems , 1994 .

[11] Thomas Schnelle,et al. Travelling wave-driven microfabricated electrohydrodynamic pumps for liquids , 1994 .

[12] P. Bergveld,et al. An Integrated Micromachined Electrochemical Pump and Dosing System , 1999, Biomedical microdevices.

[13] Jens Anders Branebjerg,et al. Microfluidics-a review , 1993 .