Influence of Open Biopsy on Survival of Osteosarcoma Patients

The relationship between enforcement of open biopsy and survival was studied retrospectively in osteosarcoma patients who underwent various kinds of preoperative chemotherapy. Sixty-three patients were included in this study, all of whom had no obvious metastatic lesion at the time of the biopsy. Patients were classified into the following 4 groups by difference of preoperative chemotherapy: group 1, Rosen's T12 protocol; group 2, Methotrexate and Cisplatin protocol; group 3, other chemotherapy; and group 4, no chemotherapy. Patients treated with Rosen's T12 protocol chemotherapy have all survived disease free. Our results suggest that open biopsy does not have a significant influence on the survival of osteosarcoma patients treated with effective adjuvant chemotherapy.

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