LYMPHOID NEOPLASIA Reed-Sternberg cell – derived lymphotoxin- a activates endothelial cells to enhance T-cell recruitment in classical Hodgkin lymphoma

in involved lymph nodes from cHL patients. Our study also shows that although NF- k B and AP-1 are involved, the cyclooxygenase (COX) pathway is the dominant regulator of LT a production in HRS cells. Using pharmacologicalinhibitors,ourdatasuggestthatactivityofCOX1,butnotofCOX2,directlyregulatestheexpressionofnuclearc-Fos in HRS cells. Our findings suggest that HRS cell-derived LT a is an important mediator that contributes to T cell recruitment into lesional lymph nodes in cHL. ( Blood . 2014;124(19):2973-2982)