Glutathione and drug resistance.

[1]  P. Borst,et al.  Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[2]  R. Ozols,et al.  Role of platinum-DNA adduct formation and removal in cisplatin resistance in human ovarian cancer cell lines. , 1994, Biochemical pharmacology.

[3]  G. Chu,et al.  Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair. , 1994, The Journal of biological chemistry.

[4]  M. Lyttle,et al.  Isozyme-specific glutathione-S-transferase inhibitors: design and synthesis. , 1994, Journal of medicinal chemistry.

[5]  K. Cowan,et al.  Antineoplastic Drug Resistance and Breast Cancer , 1993, Annals of the New York Academy of Sciences.

[6]  D. Noe,et al.  Kinetic analysis of the reaction of melphalan with water, phosphate, and glutathione. , 1993, Drug metabolism and disposition: the biological fate of chemicals.

[7]  R. Ozols,et al.  Cross-resistance to diverse drugs is associated with primary cisplatin resistance in ovarian cancer cell lines. , 1993, Cancer research.

[8]  G. Batist,et al.  Expression of a rat glutathione-S-transferase complementary DNA in rat mammary carcinoma cells: impact upon alkylator-induced toxicity. , 1993, Cancer research.

[9]  A. Conte,et al.  Reversing of chlorambucil resistance by ethacrynic acid in a B‐CLL patient , 1993, British journal of haematology.

[10]  T. Ishikawa,et al.  Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance. , 1993, The Journal of biological chemistry.

[11]  P. Houghton,et al.  Preclinical and Clinical Modulation of Anticancer Drugs , 1993 .

[12]  M. Anderson,et al.  Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase. , 1993, The Journal of biological chemistry.

[13]  S. Egyházi,et al.  Contribution of glutathione transferase M3-3 to 1,3-bis(2-chloroethyl)-1-nitrosourea resistance in a human non-small cell lung cancer cell line. , 1993, Cancer research.

[14]  A. Godwin,et al.  Cloning and characterization of human colon glyoxalase-I. , 1993, The Journal of biological chemistry.

[15]  Bing-he Xu,et al.  Effect of buthionine sulfoximine and ethacrynic acid on cytotoxic activity of mitomycin C analogues BMY 25282 and BMY 25067. , 1992, Cancer research.

[16]  T. Ishikawa,et al.  The ATP-dependent glutathione S-conjugate export pump. , 1992, Trends in biochemical sciences.

[17]  H. Hollema,et al.  Glutathione S-transferase activity and isoenzyme composition in benign ovarian tumours, untreated malignant ovarian tumours, and malignant ovarian tumours after platinum/cyclophosphamide chemotherapy. , 1992, British Journal of Cancer.

[18]  V. Bohr,et al.  ERCC1 and ERCC2 expression in malignant tissues from ovarian cancer patients. , 1992, Journal of the National Cancer Institute.

[19]  G. Wilding,et al.  Increase in gamma-glutamylcysteine synthetase activity and steady-state messenger RNA levels in melphalan-resistant DU-145 human prostate carcinoma cells expressing elevated glutathione levels. , 1992, Cancer research.

[20]  P. O'Connor,et al.  Increased gene-specific repair of cisplatin interstrand cross-links in cisplatin-resistant human ovarian cancer cell lines , 1992, Molecular and cellular biology.

[21]  S. Orrenius,et al.  Demonstration of nuclear compartmentalization of glutathione in hepatocytes. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[22]  A. Godwin,et al.  High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[23]  R. Ozols,et al.  Depletion of glutathione in normal and malignant human cells in vivo by buthionine sulfoximine: clinical and biochemical results. , 1992, Journal of the National Cancer Institute.

[24]  W. Pearson,et al.  Nomenclature for human glutathione transferases. , 1992, The Biochemical journal.

[25]  H. Warenius,et al.  Cellular glutathione (GSH) and glutathione S-transferase (GST) activity in human ovarian tumor biopsies following exposure to alkylating agents. , 1992, International journal of radiation oncology, biology, physics.

[26]  T. Hamilton,et al.  Ovarian cancer, Part I: Biology. , 1992, Current problems in cancer.

[27]  K. Tew,et al.  Immunohistochemical localization of glutathione S-transferases alpha, mu, and pi in normal tissue and carcinomas from human colon. , 1991, Carcinogenesis.

[28]  R. Ozols,et al.  Phase I study of thiotepa in combination with the glutathione transferase inhibitor ethacrynic acid. , 1991, Cancer Research.

[29]  W. Zeller,et al.  Augmentation of cisplatin (DDP) cytotoxicity in vivo by DL-buthionine sulfoximine (BSO) in DDP-sensitive and-resistant rat ovarian tumors and its relation to DNA interstrand cross links. , 1991, Anticancer research.

[30]  K. Tew,et al.  Enzymatic conjugation of chlorambucil with glutathione by human glutathione S-transferases and inhibition by ethacrynic acid. , 1991, Biochemical pharmacology.

[31]  L. Kèlland,et al.  The relationships between glutathione, glutathione-S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines. , 1991, British Journal of Cancer.

[32]  N. Saijo,et al.  Metallothionein content correlates with the sensitivity of human small cell lung cancer cell lines to cisplatin. , 1991, Cancer research.

[33]  D. Crowther,et al.  Metallothionein levels in ovarian tumours before and after chemotherapy. , 1991, British Journal of Cancer.

[34]  M. Wainberg,et al.  Increased DNA synthesis and repair-enzyme expression in lymphocytes from patients with chronic lymphocytic leukemia resistant to nitrogen mustards. , 1991, Journal of the National Cancer Institute.

[35]  B. Ketterer,et al.  Theta, a new class of glutathione transferases purified from rat and man. , 1991, The Biochemical journal.

[36]  A. Eastman,et al.  Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation. , 1991, The Journal of clinical investigation.

[37]  B. Teicher,et al.  Characteristics of five human tumor cell lines and sublines resistant to cis‐diamminedichloroplatinum(II) , 1991, International journal of cancer.

[38]  A. Meister.  Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy. , 1991, Pharmacology & therapeutics.

[39]  J. Hansson,et al.  Sensitization of human melanoma cells to the cytotoxic effect of melphalan by the glutathione transferase inhibitor ethacrynic acid. , 1991, Cancer research.

[40]  C. Wolf,et al.  Molecular mechanisms of drug resistance. , 1990, The Biochemical journal.

[41]  A. Eastman,et al.  Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia. , 1990, Biochemical pharmacology.

[42]  B. Hill,et al.  An evaluation of the role of glutathione and its associated enzymes in the expression of differential sensitivities to antitumour agents shown by a range of human tumour cell lines. , 1990, Biochemical pharmacology.

[43]  P. van Bladeren,et al.  Inhibition of rat and human glutathione S-transferase isoenzymes by ethacrynic acid and its glutathione conjugate. , 1990, Biochemical pharmacology.

[44]  V. Ling,et al.  Identification of a membrane glycoprotein overexpressed in murine lymphoma sublines resistant to cis-diamminedichloroplatinum(II). , 1990, The Journal of biological chemistry.

[45]  N. Mulder,et al.  The role of glutathione in resistance to cisplatin in a human small cell lung cancer cell line. , 1990, British Journal of Cancer.

[46]  C. Townsend,et al.  Changes in glutathione content and resistance to anticancer agents in human stomach cancer cells induced by treatments with melphalan in vitro. , 1990, Cancer research.

[47]  K. Tew,et al.  Characterization of glutathione S-transferase expression in lymphocytes from chronic lymphocytic leukemia patients. , 1990, Cancer research.

[48]  C. Sorenson,et al.  Analysis of events associated with cell cycle arrest at G2 phase and cell death induced by cisplatin. , 1990, Journal of the National Cancer Institute.

[49]  A. Monks,et al.  Metallothionein gene expression and resistance to cisplatin in human ovarian cancer , 1990, International journal of cancer.

[50]  T. Tanaka,et al.  Increased removal of DNA-bound platinum in a human ovarian cancer cell line resistant to cis-diamminedichloroplatinum(II). , 1990, Cancer research.

[51]  K. Kohno,et al.  Drug resistance to cis-diamminedichloroplatinum (II) in Chinese hamster ovary cell lines transfected with glutathione S-transferase pi gene. , 1990, Biochemical and biophysical research communications.

[52]  A. Pa,et al.  Cellular pharmacology of cisplatin: perspectives on mechanisms of acquired resistance. , 1990 .

[53]  S. Mirski,et al.  Alterations in glutathione and glutathione-related enzymes in a multidrug-resistant small cell lung cancer cell line. , 1990, Molecular pharmacology.

[54]  R. Ozols,et al.  Resistance to alkylating agents and cisplatin: insights from ovarian carcinoma model systems. , 1990, Pharmacology & therapeutics.

[55]  E. Katz,et al.  The effect of DNA polymerase inhibitors on the cytotoxicity of cisplatin in human ovarian carcinoma cells. , 1990, Cancer communications.

[56]  J. Doroshow,et al.  Role of the glutathione-glutathione peroxidase cycle in the cytotoxicity of the anticancer quinones. , 1990, Pharmacology & therapeutics.

[57]  H. Lohrer,et al.  Overexpression of metallothionein in CHO cells and its effect on cell killing by ionizing radiation and alkylating agents. , 1989, Carcinogenesis.

[58]  F. Ali-Osman.  Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione. , 1989, Cancer research.

[59]  R. Sutherland,et al.  Changes in cellular glutathione content during adriamycin treatment in human ovarian cancer--a possible indicator of chemosensitivity. , 1989, British Journal of Cancer.

[60]  B. Mannervik,et al.  Denitrosation of 1,3-bis(2-chloroethyl)-1-nitrosourea by class mu glutathione transferases and its role in cellular resistance in rat brain tumor cells. , 1989, Cancer research.

[61]  R. Ozols,et al.  Effect of glutathione on DNA repair in cisplatin-resistant human ovarian cancer cell lines. , 1989, Journal of the National Cancer Institute.

[62]  J. Endicott,et al.  The biochemistry of P-glycoprotein-mediated multidrug resistance. , 1989, Annual review of biochemistry.

[63]  A. Fojo,et al.  Mechanisms of resistance to cisplatin and alkylating agents. , 1989, Cancer treatment and research.

[64]  R. Ozols,et al.  Enhanced DNA repair and resistance to cisplatin in human ovarian cancer. , 1988, Biochemical pharmacology.

[65]  A. Fojo,et al.  Increased DNA repair as a mechanism of acquired resistance to cis-diamminedichloroplatinum (II) in human ovarian cancer cell lines. , 1988, Cancer research.

[66]  D. Hamer,et al.  Overexpression of metallothionein confers resistance to anticancer drugs. , 1988, Science.

[67]  C. Wolf,et al.  Glutathione and glutathione-dependent enzymes in ovarian adenocarcinoma cell lines derived from a patient before and after the onset of drug resistance: intrinsic differences and cell cycle effects. , 1988, Carcinogenesis.

[68]  A. Eastman,et al.  Enhanced DNA repair as a mechanism of resistance to cis-diamminedichloroplatinum(II). , 1988, Biochemistry.

[69]  H. Schuitemaker,et al.  cis-diamminedichloroplatinum(II)-resistant sublines derived from two human ovarian tumor cell lines. , 1988, Cancer research.

[70]  K. Tew,et al.  9 – Glutathione S-Transferases and Anticancer Drug Resistance , 1988 .

[71]  N. Oleinick,et al.  Inhibition of radiation-induced DNA-protein cross-link repair by glutathione depletion with L-buthionine sulfoximine. , 1988, NCI monographs : a publication of the National Cancer Institute.

[72]  A. Sancar,et al.  DNA repair enzymes. , 1988, Annual review of biochemistry.

[73]  E. Vries,et al.  Mechanisms of cellular resistance to cisplatin , 1988, Medical oncology and tumor pharmacotherapy.

[74]  B. Mannervik,et al.  Glutathione transferases--structure and catalytic activity. , 1988, CRC critical reviews in biochemistry.

[75]  P C Hanawalt,et al.  Heterogeneous DNA damage and repair in the mammalian genome. , 1987, Cancer research.

[76]  V. Bohr,et al.  DNA repair in the metallothionein gene increases with transcriptional activation. , 1987, Nucleic acids research.

[77]  A. Harris,et al.  Reduced levels of drug-induced DNA cross-linking in nitrogen mustard-resistant Chinese hamster ovary cells expressing elevated glutathione S-transferase activity. , 1987, Cancer research.

[78]  A. Fojo,et al.  Multidrug resistance in ovarian cancer , 1987, Cancer.

[79]  K. Tew,et al.  Glutathione S-transferases in human prostate. , 1987, Biochimica et biophysica acta.

[80]  W. Bodell,et al.  Glutathione and related enzymes in rat brain tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea and nitrogen mustard. , 1987, Cancer research.

[81]  A. Eastman.  Cross-linking of glutathione to DNA by cancer chemotherapeutic platinum coordination complexes. , 1987, Chemico-biological interactions.

[82]  R C Young,et al.  Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues. , 1987, Cancer research.

[83]  E. Friedberg.  The Molecular Biology of Nucleotide Excision Repair of DNA: Recent Progress , 1987, Journal of Cell Science.

[84]  B. Czernobilsky.  Common Epithelial Tumors of the Ovary , 1987 .

[85]  R. Ozols,et al.  Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione. , 1987, Biochemical pharmacology.

[86]  P. Hanawalt,et al.  Characterization of a DNA repair domain containing the dihydrofolate reductase gene in Chinese hamster ovary cells. , 1986, The Journal of biological chemistry.

[87]  R. Ozols,et al.  Serial determinations of glutathione levels and glutathione-related enzyme activities in human tumor cells in vitro. , 1986, Biochemical pharmacology.

[88]  B. Mannervik.  The isoenzymes of glutathione transferase. , 2006, Advances in enzymology and related areas of molecular biology.

[89]  M. Winker,et al.  Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion. , 1985, Biochemical pharmacology.

[90]  Wang Al,et al.  Increased glutathione-S-transferase activity in a cell line with acquired resistance to nitrogen mustards. , 1985 .

[91]  Barnett Rosenberg,et al.  Charles F. Kettring prize. Fundamental studies with cisplatin , 1985 .

[92]  M. Winker,et al.  Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine. , 1985, Cancer research.

[93]  P. Hanawalt,et al.  DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall , 1985, Cell.

[94]  R. Ozols,et al.  Potentiation of melphalan cytotoxicity in human ovarian cancer cell lines by glutathione depletion. , 1984, Cancer research.

[95]  G. Goldenberg,et al.  Membrane transport, sulfhydryl levels and DNA cross-linking in Chinese hamster ovary cell mutants sensitive and resistant to melphalan. , 1983, Biochemical pharmacology.

[96]  J. Byfield,et al.  Carrier-dependent and carrier-independent transport of anti-cancer alkylating agents , 1981, Nature.

[97]  M. Edgren,et al.  Induction and repair of single-strand DNA breaks after X-irradiation of human fibroblasts deficient in glutathione. , 1981, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[98]  N. Kaplowitz,et al.  Binding of ethacrynic acid to hepatic glutathione S-transferases in vivo in the rat. , 1980, Biochemical pharmacology.

[99]  A. Meister,et al.  Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). , 1979, The Journal of biological chemistry.

[100]  D. Vistica.  Cytotoxicity as an indicator for transport mechanism: evidence that melphalan is transported by two leucine-preferring carrier systems in the L1210 murine leukemia cell. , 1979, Biochimica et biophysica acta.

[101]  W B Jakoby,et al.  The glutathione S-transferases: a group of multifunctional detoxification proteins. , 1978, Advances in enzymology and related areas of molecular biology.