Uterine Artery Embolization for Heavy Menstrual Bleeding

Uterine artery embolization (UAE) as a treatment option for fibroids was first reported by Ravina in 1995. Although rapidly adopted by enthusiasts, many were skeptical and its introduction varied widely across the globe. It was not until randomized controlled trials and registries were published and national guidance statements issued that UAE was accepted as a safe and proven treatment for fibroids. The technique is now established as one of the treatment options to be discussed with patients as an alternative to surgery for fibroid-associated heavy menstrual bleeding. Research is on-going to evaluate the relative merits of UAE compared with other medical and surgical treatment options for heavy menstrual bleeding, particularly for women wishing to maintain their fertility.

[1]  J. Reekers,et al.  Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids: 10-year outcomes from the randomized EMMY trial. , 2007, American journal of obstetrics and gynecology.

[2]  L. Murray,et al.  Randomized Comparison of Uterine Artery Embolization (UAE) with Surgical Treatment in Patients with Symptomatic Uterine Fibroids (REST Trial): Subanalysis of 5-Year MRI Findings , 2013, CardioVascular and Interventional Radiology.

[3]  I. Osterloh,et al.  Ulipristal acetate versus leuprolide acetate for uterine fibroids. , 2012, The New England journal of medicine.

[4]  J. Moss,et al.  Clinical Results of Fibroid Embolisation, Trials and Registries , 2012 .

[5]  M. Hickey,et al.  Uterine artery embolization for symptomatic uterine fibroids. , 2012, The Cochrane database of systematic reviews.

[6]  Jessica S. Horst,et al.  Uterine Artery Embolization versus Myomectomy: Impact on Quality of Life—Results of the FUME (Fibroids of the Uterus: Myomectomy versus Embolization) Trial , 2012, CardioVascular and Interventional Radiology.

[7]  Z. Min,et al.  Uterine artery embolization versus surgery for symptomatic uterine fibroids: a randomized controlled trial and a meta-analysis of the literature , 2012, Archives of Gynecology and Obstetrics.

[8]  J. Reekers,et al.  Uterine artery embolization versus surgery in the treatment of symptomatic fibroids: a systematic review and metaanalysis. , 2011, American journal of obstetrics and gynecology.

[9]  M. Lumsden,et al.  Randomised comparison of uterine artery embolisation (UAE) with surgical treatment in patients with symptomatic uterine fibroids (REST trial): 5‐year results , 2011, BJOG : an international journal of obstetrics and gynaecology.

[10]  L. Bonomo,et al.  Long-term effects of uterine fibroid embolization on ovarian reserve: a prospective cohort study. , 2010, Fertility and sterility.

[11]  K. Cooper,et al.  The effects of uterine artery embolisation and surgical treatment on ovarian function in women with uterine fibroids , 2010, BJOG : an international journal of obstetrics and gynaecology.

[12]  H. Manninen,et al.  Uterine artery embolisation versus hysterectomy for leiomyomas: primary and 2-year follow-up results of a randomised prospective clinical trial , 2010, European Radiology.

[13]  H. Homer,et al.  Uterine artery embolization for fibroids is associated with an increased risk of miscarriage. , 2010, Fertility and sterility.

[14]  J. Reekers,et al.  Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids: 5-year outcome from the randomized EMMY trial. , 2010, American journal of obstetrics and gynecology.

[15]  M. Mára,et al.  Midterm Clinical and First Reproductive Results of a Randomized Controlled Trial Comparing Uterine Fibroid Embolization and Myomectomy , 2007, CardioVascular and Interventional Radiology.

[16]  J. Reekers,et al.  Loss of ovarian reserve after uterine artery embolization: a randomized comparison with hysterectomy. , 2007, Human reproduction.

[17]  L. Murray,et al.  Uterine-artery embolization versus surgery for symptomatic uterine fibroids. , 2007, The New England journal of medicine.

[18]  M. A. de la Cal,et al.  Uterine fibroids: uterine artery embolization versus abdominal hysterectomy for treatment--a prospective, randomized, and controlled clinical trial. , 2003, Radiology.