A vision and a prescription for big data–enabled medicine

Genetic, environmental and socioeconomic factors render humanity remarkably diverse. '-Omic' and sensor technologies permit the capture of this diversity with unprecedented precision. Leveraging these technologies in clinical decision making will help to bring about the long-heralded personalization of medicine.

[1]  Bastian R. Angermann,et al.  Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses , 2008, The Journal of experimental medicine.

[2]  Bijoya Chatterjee,et al.  Prakriti-based medicine: A step towards personalized medicine , 2011, Ayu.

[3]  Damien Chaussabel,et al.  Democratizing systems immunology with modular transcriptional repertoire analyses , 2014, Nature Reviews Immunology.

[4]  H M Buckland,et al.  The Reith lectures , 1981 .

[5]  J. Mege,et al.  Chronic hepatitis E virus infection is specifically associated with an interferon-related transcriptional program. , 2013, The Journal of infectious diseases.

[6]  N. Friedman,et al.  Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis , 2011, Cell.

[7]  S. Brenner Sequences and consequences , 2010, Philosophical Transactions of the Royal Society B: Biological Sciences.

[8]  Dirk Koczan,et al.  Interferon-beta therapy in multiple sclerosis: the short-term and long-term effects on the patients’ individual gene expression in peripheral blood , 2013, Molecular Neurobiology.

[9]  Michel Galinier,et al.  Blood Signature of Pre-Heart Failure: A Microarrays Study , 2011, PloS one.

[10]  Virginia Pascual,et al.  A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus. , 2008, Immunity.

[11]  Rui Mei,et al.  Type I interferon signaling genes in recurrent major depression: increased expression detected by whole-blood RNA sequencing , 2013, Molecular Psychiatry.

[12]  Virginia Pascual,et al.  Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood , 2003, The Journal of experimental medicine.

[13]  Eva K. Lee,et al.  Systems Biology of Seasonal Influenza Vaccination in Humans , 2011, Nature Immunology.

[14]  Eva K. Lee,et al.  Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans , 2009, Nature Immunology.

[15]  Shuzhao Li,et al.  Vaccine Activation of the Nutrient Sensor GCN2 in Dendritic Cells Enhances Antigen Presentation , 2014, Science.

[16]  Michaela Oswald,et al.  Modular Analysis of Peripheral Blood Gene Expression in Rheumatoid Arthritis Captures Reproducible Gene Expression Changes in Tumor Necrosis Factor Responders , 2015, Arthritis & Rheumatology.

[17]  Olli Simell,et al.  Innate Immune Activity Is Detected Prior to Seroconversion in Children With HLA-Conferred Type 1 Diabetes Susceptibility , 2014, Diabetes.

[18]  Virginia Pascual,et al.  Modular Transcriptional Repertoire Analyses of Adults With Systemic Lupus Erythematosus Reveal Distinct Type I and Type II Interferon Signatures , 2014, Arthritis & rheumatology.

[19]  Helder I Nakaya,et al.  TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination. , 2014, Immunity.

[20]  Kelly Domico,et al.  Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines. , 2013, Immunity.

[21]  Nathan D. Wolfe,et al.  Common and Divergent Immune Response Signaling Pathways Discovered in Peripheral Blood Mononuclear Cell Gene Expression Patterns in Presymptomatic and Clinically Apparent Malaria , 2006, Infection and Immunity.

[22]  M. J. Pearce,et al.  Presymptomatic Prediction of Sepsis in Intensive Care Unit Patients , 2008, Clinical and Vaccine Immunology.

[23]  R. Mott,et al.  Genomewide analysis of the host response to malaria in Kenyan children. , 2005, The Journal of infectious diseases.

[24]  Aaron R Quinlan,et al.  A reference bacterial genome dataset generated on the MinION™ portable single-molecule nanopore sequencer , 2014, GigaScience.

[25]  P. Parrilla,et al.  Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients. , 2008, The Journal of clinical investigation.

[26]  B. Pulendran Systems vaccinology: Probing humanity’s diverse immune systems with vaccines , 2014, Proceedings of the National Academy of Sciences.

[27]  Sandra Romero-Steiner,et al.  Molecular signatures of antibody responses derived from a systems biological study of 5 human vaccines , 2013, Nature Immunology.

[28]  J. Broderick,et al.  Gene Expression Profiling of Blood for the Prediction of Ischemic Stroke , 2010, Stroke.

[29]  M. Suthanthiran,et al.  Identification of a B cell signature associated with renal transplant tolerance in humans. , 2010, The Journal of clinical investigation.

[30]  Virginia Pascual,et al.  An Interferon-Inducible Neutrophil-Driven Blood Transcriptional Signature in Human Tuberculosis , 2010, Nature.

[31]  J. Banchereau,et al.  Whole Blood Gene Expression Profiles to Assess Pathogenesis and Disease Severity in Infants with Respiratory Syncytial Virus Infection , 2013, PLoS medicine.

[32]  L. Carin,et al.  A Host Transcriptional Signature for Presymptomatic Detection of Infection in Humans Exposed to Influenza H1N1 or H3N2 , 2013, PloS one.

[33]  F. Marincola,et al.  Gene-expression profiling of the response of peripheral blood mononuclear cells and melanoma metastases to systemic IL-2 administration , 2002, Genome Biology.

[34]  Virginia Pascual,et al.  How the study of children with rheumatic diseases identified interferon‐α and interleukin‐1 as novel therapeutic targets , 2008, Immunological reviews.