Studies of the influence of ochratoxin A on immune and defence reactions in the mouse model

Summary. In the mouse model, the mycotoxin ochratoxin A has a non‐selective suppressive effect on various immune and defence reactions. Apart from weight depression, lymphopenia, neutrophilia and eosinophilia, antibody‐producing cells, antibody titres in blood serum and phagocytosis of Escherichia coli by blood phagocytes become suppressed. Moreover, immunized animals show a lower survival rate after experimental infection with Pasteurella multocida as well as an increase in oxygen radicals in blood cells.

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