MAPL SUMOylation of Drp1 Stabilizes an ER/Mitochondrial Platform Required for Cell Death.

[1]  Quan Chen,et al.  Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy , 2015, Autophagy.

[2]  Elisa Greotti,et al.  Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling , 2015, Proceedings of the National Academy of Sciences.

[3]  D. Newmeyer,et al.  Mitochondrial shape governs BAX-induced membrane permeabilization and apoptosis. , 2015, Molecular cell.

[4]  Urszula Wasik,et al.  Non-nuclear function of sumoylated proteins. , 2014, Biochimica et biophysica acta.

[5]  Shang-Yi Chiu,et al.  Disruption of SUMO-Specific Protease 2 Induces Mitochondria Mediated Neurodegeneration , 2014, PLoS genetics.

[6]  Xiaodong Wang,et al.  Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis , 2014, Proceedings of the National Academy of Sciences.

[7]  D. Andrews,et al.  Regulating cell death at, on, and in membranes. , 2014, Biochimica et biophysica acta.

[8]  Jina Yun,et al.  MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin , 2014, eLife.

[9]  G. Gillet,et al.  Bcl-wav and the mitochondrial calcium uniporter drive gastrula morphogenesis in zebrafish , 2013, Nature Communications.

[10]  F. Melchior,et al.  Sumoylation: a regulatory protein modification in health and disease. , 2013, Annual review of biochemistry.

[11]  P. Walter,et al.  ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast , 2013, eLife.

[12]  J. Henley,et al.  SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia , 2013, The EMBO journal.

[13]  Stefan R. Pulver,et al.  Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics , 2013, Front. Mol. Neurosci..

[14]  H. Higgs,et al.  An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2 , 2013, Science.

[15]  K. Elgass,et al.  Recent advances into the understanding of mitochondrial fission. , 2013, Biochimica et biophysica acta.

[16]  P. Gluckman,et al.  The ubiquitin ligase Mul1 induces mitophagy in skeletal muscle in response to muscle-wasting stimuli. , 2012, Cell metabolism.

[17]  T. Kuwana,et al.  Bax Activation Initiates the Assembly of a Multimeric Catalyst that Facilitates Bax Pore Formation in Mitochondrial Outer Membranes , 2012, PLoS biology.

[18]  Su-Jae Lee,et al.  Akt is negatively regulated by the MULAN E3 ligase , 2012, Cell Research.

[19]  T. Kuwana,et al.  Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis , 2012, Cell.

[20]  I. Park,et al.  E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53 , 2011, Cell Death and Differentiation.

[21]  D. Bowtell,et al.  Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. , 2011, Molecular cell.

[22]  Matthew West,et al.  ER Tubules Mark Sites of Mitochondrial Division , 2011, Science.

[23]  J. Martinou,et al.  Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. , 2011, Developmental cell.

[24]  I. Ambudkar,et al.  Faculty Opinions recommendation of A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. , 2011 .

[25]  V. Mootha,et al.  Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter , 2011, Nature.

[26]  P. Pinton,et al.  Mitochondria associated membranes (MAMs) as critical hubs for apoptosis , 2011, Communicative & Integrative Biology.

[27]  R. Schwarzenbacher,et al.  Membrane Remodeling Induced by the Dynamin-Related Protein Drp1 Stimulates Bax Oligomerization , 2010, Cell.

[28]  Luca Scorrano,et al.  An intimate liaison: spatial organization of the endoplasmic reticulum–mitochondria relationship , 2010, The EMBO journal.

[29]  V. Mootha,et al.  MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake , 2010, Nature.

[30]  M. Colombini Ceramide channels and their role in mitochondria-mediated apoptosis. , 2010, Biochimica et biophysica acta.

[31]  D. Green,et al.  The BCL-2 family reunion. , 2010, Molecular cell.

[32]  Seamus J. Martin,et al.  Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis. , 2009, Molecular cell.

[33]  H. McBride,et al.  MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission , 2009, EMBO reports.

[34]  H. McBride,et al.  Translocation of SenP5 from the Nucleoli to the Mitochondria Modulates DRP1-dependent Fission during Mitosis* , 2009, The Journal of Biological Chemistry.

[35]  L. Scorrano,et al.  Mitofusin 2 tethers endoplasmic reticulum to mitochondria , 2008, Nature.

[36]  P. Bernardi,et al.  Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria , 2008, Proceedings of the National Academy of Sciences.

[37]  Z. Zhai,et al.  GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth , 2008, Cell Research.

[38]  S. Cullen,et al.  Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release. , 2008, Molecular cell.

[39]  J. Martinou,et al.  Contributions to Bax insertion and oligomerization of lipids of the mitochondrial outer membrane , 2008, Cell Death and Differentiation.

[40]  Akio Matsuda,et al.  Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling , 2008, PloS one.

[41]  Miguel A. Andrade-Navarro,et al.  Cargo-Selected Transport from the Mitochondria to Peroxisomes Is Mediated by Vesicular Carriers , 2008, Current Biology.

[42]  A. Strasser,et al.  The BCL-2 protein family: opposing activities that mediate cell death , 2008, Nature Reviews Molecular Cell Biology.

[43]  S. Strack,et al.  Reversible phosphorylation of Drp1 by cyclic AMP‐dependent protein kinase and calcineurin regulates mitochondrial fission and cell death , 2007, EMBO reports.

[44]  M. Dasso,et al.  Modification in reverse: the SUMO proteases. , 2007, Trends in biochemical sciences.

[45]  H. McBride,et al.  Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death , 2007, The Journal of cell biology.

[46]  H. McBride,et al.  The SUMO protease SENP5 is required to maintain mitochondrial morphology and function , 2007, Journal of Cell Science.

[47]  J. Martinou,et al.  Inhibiting the Mitochondrial Fission Machinery Does Not Prevent Bax/Bak-Dependent Apoptosis , 2006, Molecular and Cellular Biology.

[48]  C. Mannella,et al.  Structural and functional features and significance of the physical linkage between ER and mitochondria , 2006, The Journal of cell biology.

[49]  Sara Cipolat,et al.  OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion , 2006, Cell.

[50]  Qing Zhao,et al.  Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors , 2005, Nature chemical biology.

[51]  H. McBride,et al.  Endoplasmic reticulum BIK initiates DRP1‐regulated remodelling of mitochondrial cristae during apoptosis , 2005, The EMBO journal.

[52]  R. Rizzuto,et al.  Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis. , 2004, Molecular cell.

[53]  H. McBride,et al.  Sumo1 Conjugates Mitochondrial Substrates and Participates in Mitochondrial Fission , 2004, Current Biology.

[54]  Tullio Pozzan,et al.  BAX and BAK Regulation of Endoplasmic Reticulum Ca2+: A Control Point for Apoptosis , 2003, Science.

[55]  S. Frank,et al.  Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis , 2002, The Journal of cell biology.

[56]  Luca Scorrano,et al.  A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. , 2002, Developmental cell.

[57]  S. Frank,et al.  The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. , 2001, Developmental cell.

[58]  Pál Pacher,et al.  Propagation of the apoptotic signal by mitochondrial waves , 2001, The EMBO journal.

[59]  Junying Yuan,et al.  Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis , 1998, Cell.

[60]  Xiaodong Wang,et al.  Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors , 1998, Cell.

[61]  Y. Hsu,et al.  Nonionic Detergents Induce Dimerization among Members of the Bcl-2 Family* , 1997, The Journal of Biological Chemistry.