论文信息 - A CASE OF BREAST FIBROMATOSIS INCLUDING A PORTION DIFFICULT TO DIFFERENTIATE FROM CLEAR CELL CARCINOMA

A CASE OF BREAST FIBROMATOSIS INCLUDING A PORTION DIFFICULT TO DIFFERENTIATE FROM CLEAR CELL CARCINOMA

Clear cell carcinomaは乳腺原発として稀に発生する一方,多臓器からの転移としても起こりうる.今回clear cell carcinomaと鑑別を要した乳腺腫瘤の1例を経験したので報告する.症例は41歳,女性.右乳房腫瘤を主訴に来院.右乳房A領域に1.5cm大の硬結を触知.画像検査も含め乳癌を疑いcore needle biopsyを2回施行したが,確定診断に至らなかったため,最終的に切除生検を施行した.病理所見では,主病巣はfibromatosisであったが,脂肪組織内にclear cell carcinomaも疑わせる細胞塊を認めた.連続切片にて小葉への連続性を認めたため,小葉のclear cell metaplasiaと診断することができた. Clear cell metaplasiaはその疾患概念を理解していないと,一見clear cell carcinomaと診断することもあるので注意を要するものと考えられた.

K. Hatakeyama | Y. Koyama | C. Kanbayashi | K. Kaneko

[1] 誠一玉井,et al. 乳腺glycogen-rich clear cell carcinomaの1例 , 1998 .

[2] M. Hayes,et al. Glycogen‐Rich Clear Cell Carcinoma of the Breast A Clinicopathologic Study of 21 Cases , 1995, The American journal of surgical pathology.

[3] L. Guillou,et al. Gynecomastia with unusual intraductal "clear cell" changes mimicking pagetoid ductal spread of lobular neoplasia. , 1995, Pathology, research and practice.

[4] C. Wells,et al. Clear cell metaplasia of the breast: A lesion showing eccrine differentiation , 1989, Histopathology.

[5] B. Fisher,et al. Glycogen-rich, clear cell breast cancer: with comments concerning other clear cell variants. , 1985, Human pathology.

[6] E. Marquet,et al. Solid glycogen-rich clear cell carcinoma of the breast (a light and ultrastructural study). , 1983, American journal of clinical pathology.

[7] M. Kashgarian,et al. "Clear-cell" change within duct and lobular epithelium of the human breast. , 1982, Pathology annual.

[8] J. Urban,et al. Cancers metastatic to the breast , 1972, Cancer.