Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells.

[1]  D. Eizirik,et al.  MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA , 2009, Human molecular genetics.

[2]  F. Ortis,et al.  The role of inflammation in insulitis and β-cell loss in type 1 diabetes , 2009, Nature Reviews Endocrinology.

[3]  N. Morgan,et al.  The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes , 2009, Diabetologia.

[4]  J. Ring,et al.  Double-Stranded RNA Induces an Antiviral Defense Status in Epidermal Keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-Mediated Differential Signaling1 , 2008, The Journal of Immunology.

[5]  D. Eizirik,et al.  Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes. , 2008, Biochemical Society transactions.

[6]  C. Mathieu,et al.  Double-Stranded RNA Induces Pancreatic β-Cell Apoptosis by Activation of the Toll-Like Receptor 3 and Interferon Regulatory Factor 3 Pathways , 2008, Diabetes.

[7]  M. Yoneyama,et al.  Cytoplasmic recognition of RNA. , 2008, Advanced drug delivery reviews.

[8]  D. Swinney,et al.  Essential Role of the N-terminal Domain in the Regulation of RIG-I ATPase Activity* , 2008, Journal of Biological Chemistry.

[9]  P. Kovanen,et al.  Cytosolic Antiviral RNA Recognition Pathway Activates Caspases 1 and 31 , 2008, The Journal of Immunology.

[10]  J. Blomberg,et al.  Recent enterovirus infection in type 1 diabetes: Evidence with a novel IgM method , 2007, Journal of medical virology.

[11]  C. Cameron,et al.  5'-Triphosphate-Dependent Activation of PKR by RNAs with Short Stem-Loops , 2007, Science.

[12]  Michael G. Katze,et al.  Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity , 2007, Journal of Virology.

[13]  Annika Olsson,et al.  Interferons induce an antiviral state in human pancreatic islet cells. , 2007, Virology.

[14]  M. Yoneyama,et al.  RIG-I family RNA helicases: cytoplasmic sensor for antiviral innate immunity. , 2007, Cytokine & growth factor reviews.

[15]  K. Fukase,et al.  Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines. , 2007, Molecular immunology.

[16]  U. Boggi,et al.  Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients , 2007, Proceedings of the National Academy of Sciences.

[17]  Shizuo Akira,et al.  Antiviral signaling through pattern recognition receptors. , 2006, Journal of biochemistry.

[18]  Allan R. Brasier,et al.  Retinoic Acid-Inducible Gene I Mediates Early Antiviral Response and Toll-Like Receptor 3 Expression in Respiratory Syncytial Virus-Infected Airway Epithelial Cells , 2006, Journal of Virology.

[19]  Gunther Hartmann,et al.  5'-Triphosphate RNA Is the Ligand for RIG-I , 2006, Science.

[20]  A. Pichlmair,et al.  RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates , 2006, Science.

[21]  L. O’Neill,et al.  TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. , 2006, Trends in immunology.

[22]  K. Gillespie.  Type 1 diabetes: pathogenesis and prevention , 2006, Canadian Medical Association Journal.

[23]  Michael Karin,et al.  Intracellular pattern recognition receptors in the host response , 2006, Nature.

[24]  K. Ishii,et al.  Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses , 2006, Nature.

[25]  D. Al-Khairy,et al.  Innate Immunity at the Mucosal Surface: Role of Toll-Like Receptor 3 and Toll-Like Receptor 9 in Cervical Epithelial Cell Responses to Microbial Pathogens1 , 2006, Biology of reproduction.

[26]  P. Ahlquist.  Parallels among positive-strand RNA viruses, reverse-transcribing viruses and double-stranded RNA viruses , 2006, Nature Reviews Microbiology.

[27]  M. Honeyman.  How robust is the evidence for viruses in the induction of type 1 diabetes? , 2005, Current opinion in immunology.

[28]  S. Akira,et al.  Toll-like Receptor 3 and STAT-1 Contribute to Double-stranded RNA+ Interferon-γ-induced Apoptosis in Primary Pancreatic β-Cells* , 2005, Journal of Biological Chemistry.

[29]  Z. Zhai,et al.  VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling , 2005 .

[30]  Shizuo Akira,et al.  Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity1 , 2005, The Journal of Immunology.

[31]  R. Lahesmaa,et al.  Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets , 2005, Diabetologia.

[32]  Osamu Takeuchi,et al.  Cell type-specific involvement of RIG-I in antiviral response. , 2005, Immunity.

[33]  S. Lemon,et al.  Distinct Poly(I-C) and Virus-activated Signaling Pathways Leading to Interferon-β Production in Hepatocytes* , 2005, Journal of Biological Chemistry.

[34]  S. Akira,et al.  Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease , 2005, Nature Medicine.

[35]  G. Sen,et al.  Transcriptional signaling by double-stranded RNA: role of TLR3. , 2005, Cytokine & growth factor reviews.

[36]  S. Akira,et al.  Toll-like receptors in innate immunity. , 2004, International immunology.

[37]  M. Cnop,et al.  Free Fatty Acids and Cytokines Induce Pancreatic β-Cell Apoptosis by Different Mechanisms: Role of Nuclear Factor-κB and Endoplasmic Reticulum Stress , 2004 .

[38]  L. Malmgaard.  Induction and regulation of IFNs during viral infections. , 2004, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[39]  Shizuo Akira,et al.  The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses , 2004, Nature Immunology.

[40]  T. Tuvemo,et al.  Enterovirus infections with β‐cell tropic strains are frequent in siblings of children diagnosed with type 1 diabetes children and in association with elevated levels of GAD65 antibodies , 2004, Journal of medical virology.

[41]  G. Eisenbarth,et al.  Interferon alpha--a potential link in the pathogenesis of viral-induced type 1 diabetes and autoimmunity. , 2004, Clinical immunology.

[42]  L. Wen,et al.  The Effect of Innate Immunity on Autoimmune Diabetes and the Expression of Toll-Like Receptors on Pancreatic Islets1 , 2004, The Journal of Immunology.

[43]  T. Ørntoft,et al.  Global profiling of double stranded RNA- and IFN-γ-induced genes in rat pancreatic beta cells , 2003, Diabetologia.

[44]  S. Akira,et al.  Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway , 2003, Science.

[45]  Dongbo Liu,et al.  Double-Stranded RNA Cooperates with Interferon-γ and IL-1β to Induce Both Chemokine Expression and Nuclear Factor-κB-Dependent Apoptosis in Pancreatic β-Cells: Potential Mechanisms for Viral-Induced Insulitis and β-Cell Death in Type 1 Diabetes Mellitus. , 2002, Endocrinology.

[46]  T. Taniguchi,et al.  The interferon-α/β system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors , 2002 .

[47]  B. Decallonne,et al.  An overview of real-time quantitative PCR: applications to quantify cytokine gene expression. , 2001, Methods.

[48]  R. Flavell,et al.  Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 , 2001, Nature.

[49]  D. Eizirik,et al.  Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis. , 2001, Diabetes.

[50]  Dongbo Liu,et al.  Double-Stranded Ribonucleic Acid (RNA) Induces β-Cell Fas Messenger RNA Expression and Increases Cytokine-Induced β-Cell Apoptosis. , 2001, Endocrinology.

[51]  M. Kruhøffer,et al.  Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays. , 2001, Diabetes.

[52]  H. Jun,et al.  The role of viruses in Type I diabetes: two distinct cellular and molecular pathogenic mechanisms of virus-induced diabetes in animals , 2001, Diabetologia.

[53]  F. Pattou,et al.  Persistent Infection of Human Pancreatic Islets by Coxsackievirus B Is Associated with Alpha Interferon Synthesis in β Cells , 2000, Journal of Virology.

[54]  D. Eizirik,et al.  Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokine-induced apoptosis in purified rat pancreatic beta-cells. , 2000, European cytokine network.

[55]  Dongbo Liu,et al.  Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-). , 2000, Diabetes.

[56]  J. Weill,et al.  Increased level of interferon-alpha in blood of patients with insulin-dependent diabetes mellitus: relationship with coxsackievirus B infection. , 2000, The Journal of infectious diseases.

[57]  D. Eizirik,et al.  Interleukin-1beta-induced alteration in a beta-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis. , 2000, Diabetes.

[58]  G. Clements,et al.  Enterovirus variants in the serum of children at the onset of Type 1 diabetes mellitus , 1999, Diabetic medicine : a journal of the British Diabetic Association.

[59]  J. Corbett,et al.  Double-stranded RNA Inhibits β-Cell Function and Induces Islet Damage by Stimulating β-Cell Production of Nitric Oxide* , 1999, The Journal of Biological Chemistry.

[60]  J. Krueger,et al.  Spontaneous release of stable viral double-stranded RNA into the extracellular medium by influenza virus-infected MDCK epithelial cells: implications for the viral acute phase response , 1998, Archives of Virology.

[61]  I. Fajardy,et al.  Coxsackie B virus infection and beta cell autoantibodies in newly diagnosed IDDM adult patients. , 1998, Clinical and diagnostic virology.

[62]  D. Pipeleers,et al.  Cytokines Induce Deoxyribonucleic Acid Strand Breaks and Apoptosis in Human Pancreatic Islet Cells. , 1997, Endocrinology.

[63]  D. Pipeleers,et al.  Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program. , 1996, The Journal of clinical investigation.

[64]  J. Langland,et al.  When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA. , 1996, Virology.

[65]  Å. Lernmark,et al.  Interferon Expression in the Pancreases of Patients With Type I Diabetes , 1995, Diabetes.

[66]  J. Bellanti,et al.  Poly I:C Induces Development of Diabetes Mellitus in BB Rat , 1992, Diabetes.

[67]  P. Muir,et al.  Enterovirus‐specific serum IgA antibody responses in patients with acute infections, chronic cardiac disease, and recently diagnosed insulin‐dependent diabetes mellitus , 1990, Journal of medical virology.

[68]  A. Meager,et al.  IMMUNOREACTIVE α-INTERFERON IN INSULIN-SECRETING β CELLS IN TYPE 1 DIABETES MELLITUS , 1987, The Lancet.

[69]  D. Eizirik,et al.  PTPN2 and MDA5, two candidate genes for type 1 diabetes, modify beta cell responses to double-stranded RNA , 2009 .

[70]  S. Tracy,et al.  The CVB and etiology of type 1 diabetes. , 2008, Current topics in microbiology and immunology.

[71]  M. Gale,et al.  CARD games between virus and host get a new player. , 2006, Trends in immunology.