Design, synthesis and biological evaluation of novel N-(methyl-d3) pyridazine-3-carboxamide derivatives as TYK2 inhibitors.
暂无分享,去创建一个
Fei Liu | Hongjian Xu | Xiayun Chang | Ying Zhang | Bin Wang | Yan-Li Liu | Wei-Kang Shi | Ying‐Hui He | Zhongyuan Hu | Xujing Tang | Bin Wang
[1] Sheridan M. Hoy. Deucravacitinib: First Approval , 2022, Drugs.
[2] Fei Liu,et al. Novel TYK2 Inhibitors with an N-(Methyl-d 3)pyridazine-3-carboxamide Skeleton for the Treatment of Autoimmune Diseases. , 2022, ACS medicinal chemistry letters.
[3] Stanley B. Cohen,et al. Oral surveillance and JAK inhibitor safety: the theory of relativity , 2022, Nature Reviews Rheumatology.
[4] Xiaoying Hu,et al. The JAK/STAT signaling pathway: from bench to clinic , 2021, Signal Transduction and Targeted Therapy.
[5] T. Matsuda,et al. Therapeutic Advantage of Tyk2 Inhibition for Treating Autoimmune and Chronic Inflammatory Diseases. , 2021, Biological & pharmaceutical bulletin.
[6] Subhashish Banerjee,et al. Selectivity Profile of the Tyrosine Kinase 2 Inhibitor Deucravacitinib Compared with Janus Kinase 1/2/3 Inhibitors , 2021, Dermatology and Therapy.
[7] C. Harrison,et al. Current and future status of JAK inhibitors , 2021, The Lancet.
[8] T. Torres,et al. Baricitinib for the treatment of atopic dermatitis , 2021, The Journal of dermatological treatment.
[9] P. Leszczyński,et al. TYK2 as a therapeutic target in the treatment of autoimmune and inflammatory diseases. , 2021, Immunotherapy.
[10] Baohui Song,et al. Targeting JAK/STAT signaling pathways in treatment of inflammatory bowel disease , 2021, Inflammation Research.
[11] James Lin,et al. Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2. , 2020, Journal of medicinal chemistry.
[12] D. Mccole,et al. The JAK-Inhibitor Tofacitinib Rescues Human Intestinal Epithelial Cells and Colonoids from Cytokine-Induced Barrier Dysfunction. , 2019, Inflammatory bowel diseases.
[13] S. Spergel,et al. Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. , 2019, Journal of medicinal chemistry.
[14] S. Spergel,et al. Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2). , 2019, Journal of medicinal chemistry.
[15] K. Yamaoka. Tofacitinib for the treatment of rheumatoid arthritis: an update , 2019, Expert review of clinical immunology.
[16] James Lin,et al. Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors. , 2019, ACS medicinal chemistry letters.
[17] M. González-Gay,et al. The effect of JAK1/JAK2 inhibition in rheumatoid arthritis: efficacy and safety of baricitinib. , 2019, Clinical and experimental rheumatology.
[18] H. Hoffman,et al. JAK inhibitors in autoinflammation. , 2018, The Journal of clinical investigation.
[19] J. Tokarski,et al. Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling. , 2017, MedChemComm.
[20] Yuka Kanno,et al. Mechanisms and consequences of Jak–STAT signaling in the immune system , 2017, Nature Immunology.
[21] R. Roskoski. Janus kinase (JAK) inhibitors in the treatment of inflammatory and neoplastic diseases. , 2016, Pharmacological research.
[22] Stephen R. Johnson,et al. Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain* , 2015, The Journal of Biological Chemistry.
[23] F. Powrie,et al. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. , 2006, Immunity.