Neural correlates of saccade planning in infants: a high-density ERP study.

Neural correlates of saccade planning in 6-month-old infants were investigated by high-density event-related potentials. Subjects made saccades to a target stimulus following a time gap from fixation stimulus offset (gap trials) or with the fixation stimulus still present (overlap trials). Like adults, infants were slower to make a saccade to the target when the fixation stimulus was still present. Strikingly, infants did not show clear evidence of the pre-saccadic components observed in adults which are thought to reflect cortical saccade planning processes. They did, however, show a left frontal positivity, which we suggest reflects cortical disinhibition of the colliculus initiated by fixation stimulus offset, and clear post-saccadic lambda waves. These results indicate that the frontal cortex already plays a role in action control by 6 months of age, while other aspects of cortical action planning may not yet be present in certain task situations.

[1]  G. Stechler,et al.  SOME OBSERVATIONS ON ATTENTION AND AROUSAL IN THE HUMAN INFANT , 1966 .

[2]  G. Bronson.  The postnatal growth of visual capacity. , 1974, Child development.

[3]  J. Schall,et al.  Neural Control of Voluntary Movement Initiation , 1996, Science.

[4]  G. Thickbroom,et al.  Saccade onset and offset lambda waves: relation to pattern movement visually evoked potentials , 1991, Brain Research.

[5]  Gergely Csibra,et al.  Attention and oculomotor control: A high-density ERP study of the gap effect , 1997, Neuropsychologia.

[6]  L B Stelmach,et al.  Viewing behavior: Ocular and attentional disengagement , 1993, Perception & psychophysics.

[7]  P. Kellaway,et al.  Problems and concepts in developmental neurophysiology , 1989 .

[8]  Steven A. Hillyard,et al.  Effects of spatial cuing on luminance detectability: Psychophysical and electrophysiological evidence for early selection. , 1994 .

[9]  J. Atkinson,et al.  Possible blindsight in infants lacking one cerebral hemisphere , 1992, Nature.

[10]  D. Lehmann,et al.  Principles of spatial analysis , 1987 .

[11]  Mark H. Johnson,et al.  Components of Visual Orienting in Early Infancy: Contingency Learning, Anticipatory Looking, and Disengaging , 1991, Journal of Cognitive Neuroscience.

[12]  Carey D. Balaban,et al.  The human pre-saccadic spike potential: Influences of a visual target, saccade direction, electrode laterality and instructions to perform saccades , 1985, Brain Research.

[13]  Mark H. Johnson.  Cortical Maturation and the Development of Visual Attention in Early Infancy , 1990, Journal of Cognitive Neuroscience.

[14]  R. Wurtz,et al.  Role of the rostral superior colliculus in active visual fixation and execution of express saccades. , 1992, Journal of neurophysiology.

[15]  C. Rovee-Collier,et al.  Advances in infancy research , 1981 .

[16]  F. Perrin,et al.  Spherical splines for scalp potential and current density mapping. , 1989, Electroencephalography and clinical neurophysiology.

[17]  C. Nelson,et al.  Recognition of the mother's face by six-month-old infants: a neurobehavioral study. , 1997, Child development.

[18]  P. Stratton.  Psychobiology of the Human Newborn , 1982 .

[19]  Janette Atkinson,et al.  Disengaging visual attention in the infant and adult , 1993 .

[20]  Diane Kurtzberg,et al.  Topographic analysis of human cortical potentials preceding self-initiated and visually triggered saccades , 1982, Brain Research.

[21]  M. Johnson,et al.  The inhibition of automatic saccades in early infancy. , 1995, Developmental psychobiology.

[22]  P. Reuter-Lorenz,et al.  The reduction of saccadic latency by prior offset of the fixation point: An analysis of the gap effect , 1991, Perception & psychophysics.

[23]  Daphne Maurer,et al.  The development of the temporal and nasal visual fields during infancy , 1992, Vision Research.

[24]  S. Hillyard,et al.  Modulations of sensory-evoked brain potentials indicate changes in perceptual processing during visual-spatial priming. , 1991, Journal of experimental psychology. Human perception and performance.

[25]  R. Wurtz,et al.  Visual and oculomotor functions of monkey substantia nigra pars reticulata. I. Relation of visual and auditory responses to saccades. , 1983, Journal of neurophysiology.

[26]  Richard N. Aslin,et al.  Saccadic localization of visual targets by the very young human infant , 1975 .

[27]  D. Tucker.  Spatial sampling of head electrical fields: the geodesic sensor net. , 1993, Electroencephalography and clinical neurophysiology.

[28]  H. Sohmer,et al.  Analysis of the middle latency evoked potentials to angular acceleration impulses in man. , 1996, Electroencephalography and clinical neurophysiology.

[29]  G. Goldberg,et al.  Topography of scalp potentials preceding self‐initiated saccades , 1990, Neurology.

[30]  C. C. Wood,et al.  Scalp distributions of event-related potentials: an ambiguity associated with analysis of variance models. , 1985, Electroencephalography and clinical neurophysiology.

[31]  D. Maurer,et al.  Influence of a central stimulus on infants' visual fields , 1997 .

[32]  Alan Kingstone,et al.  Visual offsets facilitate saccadic latency: Does predisengagement of visuospatial attention mediate this gap effect? , 1993 .

[33]  M. Posner,et al.  The development of attentional mechanisms. , 1980, Nebraska Symposium on Motivation. Nebraska Symposium on Motivation.

[34]  D. Lehmann,et al.  Handbook of electroencephalography and clinical neurophysiology , 1976 .

[35]  S M Ross,et al.  Saccade latency and warning signals: Stimulus onset, offset, and change as warning events , 1980, Perception & psychophysics.

[36]  Mark H. Johnson,et al.  Visual attention in infants with perinatal brain damage: Evidence of the importance of anterior lesions , 1998 .

[37]  B. J. Casey,et al.  Heart rate variability during attention phases in young infants. , 1991, Psychophysiology.