Diagnosis and Definition of Locally Advanced and Borderline Pancreas Cancer

Review Article [1] | July 15, 2016 | Oncology Journal [2], Gastrointestinal Cancer [3], Pancreatic Cancer [4] By William Small, Jr, MD [5], John P. Hayes, MD [6], W. Warren Suh, MD, MPH [7], May Abdel-Wahab, MD, PhD [8], Ross A. Abrams, MD [9], Nilofer Azad, MD [10], Prajnan Das, MD, MS, MPH [11], Jadranka Dragovic, MD [12], Karyn A. Goodman, MD [13], Salma K. Jabbour, MD [14], William E. Jones III, MD [15], Andre A. Konski, MD, MBA, MA [16], Albert C. Koong, MD, PhD [17], Rachit Kumar, MD [18], Percy Lee, MD [19], Timothy M. Pawlik, MD [20], and Joseph M. Herman, MD, MSc [21]

[1]  T. Strom,et al.  Long-term outcomes of induction chemotherapy and neoadjuvant stereotactic body radiotherapy for borderline resectable and locally advanced pancreatic adenocarcinoma , 2015, Acta oncologica.

[2]  Albert C. Koong,et al.  Phase 2 Multi-institutional Trial Evaluating Gemcitabine and Stereotactic Body Radiotherapy for Patients With Locally Advanced Unresectable Pancreatic Adenocarcinoma , 2014, Cancer.

[3]  P. Mishra,et al.  "Radiological and Surgical Implications of Neoadjuvant Treatment With FOLFIRINOX for Locally Advanced and Borderline Resectable Pancreatic Cancer." , 2015, Annals of surgery.

[4]  J. Cameron,et al.  The Role of Stereotactic Body Radiation Therapy for Pancreatic Cancer: A Single-Institution Experience , 2015, Annals of Surgical Oncology.

[5]  Jeffrey W. Clark,et al.  A phase 1/2 and biomarker study of preoperative short course chemoradiation with proton beam therapy and capecitabine followed by early surgery for resectable pancreatic ductal adenocarcinoma. , 2014, International journal of radiation oncology, biology, physics.

[6]  D. Goldstein,et al.  Impact of chemoradiotherapy (CRT) on local control and time without treatment in patients with locally advanced pancreatic cancer (LAPC) included in the international phase III LAP 07 study. , 2014 .

[7]  David Goldstein,et al.  Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. , 2013, The New England journal of medicine.

[8]  E. Fishman,et al.  Recent progress in pancreatic cancer , 2013, CA: a cancer journal for clinicians.

[9]  Edward J. Kim,et al.  A multi‐institutional phase 2 study of neoadjuvant gemcitabine and oxaliplatin with radiation therapy in patients with pancreatic cancer , 2013, Cancer.

[10]  J. Berlin,et al.  Borderline Resectable Pancreatic Cancer: Need for Standardization and Methods for Optimal Clinical Trial Design , 2013, Annals of Surgical Oncology.

[11]  D. Goldstein,et al.  Comparison of chemoradiotherapy (CRT) and chemotherapy (CT) in patients with a locally advanced pancreatic cancer (LAPC) controlled after 4 months of gemcitabine with or without erlotinib: Final results of the international phase III LAP 07 study. , 2013, Journal of Clinical Oncology.

[12]  Daniel Normolle,et al.  A phase I/II trial of intensity modulated radiation (IMRT) dose escalation with concurrent fixed-dose rate gemcitabine (FDR-G) in patients with unresectable pancreatic cancer. , 2012, International journal of radiation oncology, biology, physics.

[13]  K. Behrns FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer , 2012 .

[14]  David Cella,et al.  Gemcitabine alone versus gemcitabine plus radiotherapy in patients with locally advanced pancreatic cancer: an Eastern Cooperative Oncology Group trial. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[15]  T. Desser,et al.  Single-fraction stereotactic body radiation therapy and sequential gemcitabine for the treatment of locally advanced pancreatic cancer. , 2011, International journal of radiation oncology, biology, physics.

[16]  B. Agarwal,et al.  Imaging of pancreatic cancer: An overview. , 2011, Journal of gastrointestinal oncology.

[17]  B. B. Weitner,et al.  Phase II trial of full-dose gemcitabine and bevacizumab in combination with attenuated three-dimensional conformal radiotherapy in patients with localized pancreatic cancer. , 2011, International journal of radiation oncology, biology, physics.

[18]  M. Mino‐Kenudson,et al.  Phase I study of preoperative short-course chemoradiation with proton beam therapy and capecitabine for resectable pancreatic ductal adenocarcinoma of the head. , 2011, International journal of radiation oncology, biology, physics.

[19]  B. Yeap,et al.  Phase I/II study of Proton-based Short Course Chemoradiation and Early Surgery for Adenocarcinoma of the Pancreas , 2010 .

[20]  Tibor Schuster,et al.  Preoperative/Neoadjuvant Therapy in Pancreatic Cancer: A Systematic Review and Meta-analysis of Response and Resection Percentages , 2010, PLoS medicine.

[21]  Alison P. Klein,et al.  DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[22]  R. Semelka,et al.  Magnetic Resonance Imaging of Adenocarcinoma of the Pancreas , 2009, Topics in magnetic resonance imaging : TMRI.

[23]  B. Chauffert,et al.  Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer. Definitive results of the 2000-01 FFCD/SFRO study. , 2008, Annals of oncology : official journal of the European Society for Medical Oncology.

[24]  Jeffrey E. Lee,et al.  Preoperative gemcitabine-based chemoradiation for patients with resectable adenocarcinoma of the pancreatic head. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[25]  Jeffrey E. Lee,et al.  Preoperative gemcitabine and cisplatin followed by gemcitabine-based chemoradiation for resectable adenocarcinoma of the pancreatic head. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[26]  K. Campbell,et al.  Evaluating the Impact of a Single-Day Multidisciplinary Clinic on the Management of Pancreatic Cancer , 2008, Annals of Surgical Oncology.

[27]  J. Berlin,et al.  Full-dose gemcitabine with concurrent radiation therapy in patients with nonmetastatic pancreatic cancer: a multicenter phase II trial. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[28]  J. Drebin National Failure to Operate on Early Stage Pancreatic Cancer , 2008 .

[29]  A. Ba-Ssalamah,et al.  State-of-the-Art Magnetic Resonance Imaging of Pancreatic Cancer , 2007, Topics in magnetic resonance imaging : TMRI.

[30]  Douglas B. Evans,et al.  Induction chemotherapy selects patients with locally advanced, unresectable pancreatic cancer for optimal benefit from consolidative chemoradiation therapy , 2007, Cancer.

[31]  D. Tait,et al.  Systematic review, including meta-analyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy , 2007, British Journal of Cancer.

[32]  E. Touboul,et al.  Impact of chemoradiotherapy after disease control with chemotherapy in locally advanced pancreatic adenocarcinoma in GERCOR phase II and III studies. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[33]  P. Philip,et al.  A Multi-Institutional Phase II Trial of Preoperative Full-Dose Gemcitabine and Concurrent Radiation for Patients With Potentially Resectable Pancreatic Carcinoma , 2006, Annals of Surgical Oncology.

[34]  M. Gonen,et al.  Long-Term Survival Is Superior After Resection for Cancer in High-Volume Centers , 2005, Annals of surgery.

[35]  S. Lipsitz,et al.  A randomized phase III study of radiotherapy alone or with 5-fluorouracil and mitomycin-C in patients with locally advanced adenocarcinoma of the pancreas: Eastern Cooperative Oncology Group study E8282. , 2005, International journal of radiation oncology, biology, physics.

[36]  R. Labianca,et al.  Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[37]  D. Tyler,et al.  Neoadjuvant therapy for pancreatic cancer: the Duke experience. , 2004, Surgical oncology clinics of North America.

[38]  Jeffrey W. Clark,et al.  Long-term results of intraoperative electron beam irradiation for patients with unresectable pancreatic cancer , 2003 .

[39]  Jeffrey E. Lee,et al.  Abstracts reprinted from Journal of Clinical Oncology , 2002, Annals of Surgical Oncology.

[40]  R. Talamini,et al.  Radiotherapy and continuous infusion 5-fluorouracil in patients with nonresectable pancreatic carcinoma. , 2001, International journal of radiation oncology, biology, physics.

[41]  Jeffrey E. Lee,et al.  Rapid-fractionation preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for resectable pancreatic adenocarcinoma. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[42]  James H. Stevens,et al.  Combined intraoperative radiation and perioperative chemotherapy for unresectable cancers of the pancreas. , 1995, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[43]  D. Neuberg,et al.  Protracted intravenous fluorouracil infusion with radiation therapy in the management of localized pancreaticobiliary carcinoma: a phase I Eastern Cooperative Oncology Group Trial. , 1995, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[44]  T. Inoue,et al.  Is the long-term survival rate improved by preoperative irradiation prior to Whipple's procedure for adenocarcinoma of the pancreatic head? , 1994, Archives of surgery.

[45]  F. Ames,et al.  Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreas. , 1992, Archives of surgery.

[46]  Treatment of locally unresectable carcinoma of the pancreas: comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone. Gastrointestinal Tumor Study Group. , 1988, Journal of the National Cancer Institute.

[47]  P. Engstrom,et al.  Treatment of locally unresectable cancer of the stomach and pancreas: a randomized comparison of 5-fluorouracil alone with radiation plus concurrent and maintenance 5-fluorouracil--an Eastern Cooperative Oncology Group study. , 1985, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[48]  J. Barkin,et al.  Therapy of locally unresectable pancreatic carcinoma: A randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5‐fluorouracil), and high dose radiation + 5‐fluorouracil. The gastrointestinal tumor study group , 1981, Cancer.

[49]  C. Moertel,et al.  Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer. , 1969, Lancet.