Induction of seizures by transcranial magnetic stimulation in epileptic patients

normalities observed on the brain M R I in three of five patients were stable as were somatosensory and brainstem auditory EPs, which were and remained abnormal in four and three patients respectively. Moreover , the percentage of lymphoid cells with abnormal nuclei and of activated T-cell ( D R + ) , which are considered to be correlated with the viral load [1], remained stable. These findings suggest that zidovudine does not affect the encephalomyelopathic process associated with HTLV-1 , in the dose range used. Further studies must assess the clinical outcome of a longer t reatment to account for the possibility of a clinically stable state of a few years. Moreover, higher dosages in less disabled patients (i.e. at the onset of the disease) may help to control the chronic evolution of this disease.