MUC4 mucin-induced epithelial to mesenchymal transition: a novel mechanism for metastasis of human ovarian cancer cells

[1]  W. Seeger,et al.  Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4. , 2009, Molecular biology of the cell.

[2]  N. Smorodinsky,et al.  ERK and PI3K regulate different aspects of the epithelial to mesenchymal transition of mammary tumor cells induced by truncated MUC1. , 2009, Experimental cell research.

[3]  Yutaka Kawakami,et al.  Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. , 2009, Cancer cell.

[4]  A. Magis,et al.  A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth. , 2008, Journal of medicinal chemistry.

[5]  S. Batra,et al.  MUC4 activates HER2 signalling and enhances the motility of human ovarian cancer cells , 2008, British Journal of Cancer.

[6]  Y. Shintani,et al.  Collagen I–mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1 , 2008, The Journal of cell biology.

[7]  M. Quinn,et al.  Epithelial–mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas: An exception to the norm , 2007, Journal of cellular physiology.

[8]  K. Gravdal,et al.  A Switch from E-Cadherin to N-Cadherin Expression Indicates Epithelial to Mesenchymal Transition and Is of Strong and Independent Importance for the Progress of Prostate Cancer , 2007, Clinical Cancer Research.

[9]  P. Chaturvedi,et al.  Human MUC4 mucin induces ultra-structural changes and tumorigenicity in pancreatic cancer cells , 2007, British Journal of Cancer.

[10]  M. Nachtigal,et al.  BMP4 induces EMT and Rho GTPase activation in human ovarian cancer cells. , 2007, Carcinogenesis.

[11]  Jane L Meza,et al.  MUC4 Mucin Potentiates Pancreatic Tumor Cell Proliferation, Survival, and Invasive Properties and Interferes with Its Interaction to Extracellular Matrix Proteins , 2007, Molecular Cancer Research.

[12]  Lynette M. Smith,et al.  Aberrant expression of MUC4 in ovarian carcinoma: diagnostic significance alone and in combination with MUC1 and MUC16 (CA125) , 2006, Modern Pathology.

[13]  Keith R. Johnson,et al.  Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition , 2005, Journal of Cell Science.

[14]  C. Sommers.  The role of cadherin-mediated adhesion in breast cancer , 1996, Journal of Mammary Gland Biology and Neoplasia.

[15]  J. Massagué,et al.  Epithelial-Mesenchymal Transitions Twist in Development and Metastasis , 2004, Cell.

[16]  R. Hazan,et al.  Cadherin Switch in Tumor Progression , 2004, Annals of the New York Academy of Sciences.

[17]  S. Batra,et al.  Generation and Characterization of Anti-MUC4 Monoclonal Antibodies Reactive with Normal and Cancer Cells in Humans , 2004, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[18]  J. Meza,et al.  Inhibition of MUC4 Expression Suppresses Pancreatic Tumor Cell Growth and Metastasis , 2004, Cancer Research.

[19]  C. A. Carraway,et al.  Muc4/Sialomucin Complex in the Mammary Gland and Breast Cancer , 2001, Journal of Mammary Gland Biology and Neoplasia.

[20]  Michael A. Hollingsworth,et al.  Mucins in cancer: protection and control of the cell surface , 2004, Nature Reviews Cancer.

[21]  S. Truant,et al.  Requirement of both mucins and proteoglycans in cell‐cell dissociation and invasiveness of colon carcinoma HT‐29 cells , 2003, International journal of cancer.

[22]  R. Hazan,et al.  A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor. , 2002, Cancer cell.

[23]  J. Thiery.  Epithelial–mesenchymal transitions in tumour progression , 2002, Nature Reviews Cancer.

[24]  H. Friess,et al.  Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: a potential role of MUC4 as a tumor marker of diagnostic significance. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[25]  F. Alameda,et al.  MUC4 expression is increased in dysplastic cervical disorders. , 2001, Human pathology.

[26]  D. Querleu,et al.  Mucin gene transcripts in benign and borderline mucinous tumours of the ovary: an in situ hybridization study , 2001, The Journal of pathology.

[27]  Stuart A. Aaronson,et al.  Exogenous Expression of N-Cadherin in Breast Cancer Cells Induces Cell Migration, Invasion, and Metastasis , 2000, The Journal of cell biology.

[28]  N. Auersperg,et al.  E-cadherin induces mesenchymal-to-epithelial transition in human ovarian surface epithelium. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[29]  N. Moniaux,et al.  Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin. , 1999, The Biochemical journal.

[30]  R. Dodge,et al.  Mucin gene expression in ovarian cancers. , 1998, Cancer research.

[31]  N. Moniaux,et al.  Human mucin gene MUC4: organization of its 5'-region and polymorphism of its central tandem repeat array. , 1998, The Biochemical journal.

[32]  N. Kohno,et al.  Decreased MUC1 expression induces E-cadherin-mediated cell adhesion of breast cancer cell lines. , 1998, Cancer research.

[33]  R. Hazan,et al.  N-cadherin promotes adhesion between invasive breast cancer cells and the stroma. , 1997, Cell adhesion and communication.

[34]  H. Chen,et al.  E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms. , 1997, Journal of cell science.

[35]  J. Behrens.  Cadherins as determinants of tissue morphology and suppressors of invasion. , 1994, Acta anatomica.

[36]  P. Janmey,et al.  Actin-binding protein requirement for cortical stability and efficient locomotion. , 1992, Science.

[37]  J. Folkman.  Endothelial cells and angiogenic growth factors in cancer growth and metastasis. Introduction. , 1990, Cancer metastasis reviews.

[38]  I. Fidler,et al.  Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture. , 1990, Cancer research.