Haemodynamic responses to isoflurane anaesthesia and hypovolaemia in the dog, and their modification by propranolol.

In six dogs chronically implanted with flow and pressure transducers, equipotent inspired concentrations of halothane and isoflurane were determined as the minimum inspried concentration of each agent which would abolish an individual dog's response to paw clamping. In equipotent concentration, isoflurane (1.2%, SD 0.2%) caused less myocardial depression than halothane (1.0%, SD 0.1%). Dose-response studies were possible up to a mean inspired isoflurane concentration of 3.0%, both before and after propranolol 0.3 mg kg-1, i.v. After propranolol, sensitive indices of myocardial contractility were depressed at all concentrations of isoflurane, indicating a moderate degree of beta-receptor activation by isoflurane. The haemodynamic response to hypovolaemia during isoflurane anaesthesia was not modified by propranolol.

[1]  C. Prys‐roberts,et al.  Haemodynamic responses to enflurane anaesthesia and hypovolaemia in the dog, and their modification by propranolol. , 1979, British journal of anaesthesia.

[2]  J. Tarnow,et al.  Haemodynamics and myocardial oxygen consumption during isoflurane (forane) anaesthesia in geriatric patients. , 1977, British journal of anaesthesia.

[3]  D. Philbin,et al.  Lack of beta-adrenergic activity of isoflurane in the dog: a comparison of circulatory effects of halothane and isoflurane after propranolol administration. , 1976, British journal of anaesthesia.

[4]  C. Prys‐roberts,et al.  Interaction of Anesthesia, Beta‐receptor Blockade, and Blood Loss in Dogs with Induced Myocardial Infarction , 1976, Anesthesiology.

[5]  P. Foëx,et al.  Haemodynamic interactions of high-dose propranolol pretreatment and anaesthesia in the dog. I: Halothane dose-response studies. , 1976, British journal of anaesthesia.

[6]  P. Foëx,et al.  Proceedings: Methoxyflurane and practolol: a dangerous combination? , 1975, British journal of anaesthesia.

[7]  D. Philbin,et al.  Hemodynamic consequences of the combination of isoflurane anesthesia (1 MAC) and beta-adrenergic blockade in the dog. , 1975, Anesthesiology.

[8]  C L Graves,et al.  Cardiovascular Effects of Isoflurane in Surgical Patients , 1974, Anesthesiology.

[9]  L. B. Perry,et al.  Sympathoadrenal and hemodynamic effects of isoflurane, halothane, and cyclopropane in dogs. , 1974, Anesthesiology.

[10]  O. Kemmotsu,et al.  Inotropic Effects of Isoflurane on Mechanics of Contraction in Isolated Cat Papillary Muscles from Normal and Failing Hearts , 1973, Anesthesiology.

[11]  B. Gersh,et al.  THE EFFECTS OF HALOTHANE ON THE INTERACTIONS BETWEEN MYOCARDIAL CONTRACTILITY , AORTIC IMPEDANCE AND LEFT VENTRICULAR PERFORMANCE , 2005 .

[12]  R. Linden,et al.  The action of propranolol on the dog heart. , 1972, British journal of pharmacology.

[13]  J. Fitzgerald,et al.  The haemodynamic effects of ( )-propranolol, dexpropranolol, oxprenolol, practolol and sotalol in anaesthetised dogs. , 1972, European journal of pharmacology.

[14]  A. Dobkin,et al.  Forane (compound 469): cross-over comparison with enflurane (Ethrane), halothane, and methoxyflurane in dogs. , 1972, Canadian Anaesthetists' Society journal.

[15]  E. Eger,et al.  The Cardiovascular Effects of a New Inhalation Anesthetic, Forane, in Human Volunteers at Constant Arterial Carbon Dioxide Tension , 1971, Anesthesiology.

[16]  C. Hahn,et al.  Physical criteria for measurement of left ventricular pressure and its first derivative. , 1971, Cardiovascular research.

[17]  C. Hahn,et al.  Comparison of oxygen content of blood measured directly with values derived from measurements of oxygen tension. , 1970, British journal of anaesthesia.

[18]  C. Hahn The measurement of oxygen microcathode currents by means of a field-effect transistor operational amplifier system with digital display. , 1969, Journal of scientific instruments.

[19]  L. Jorfeldt,et al.  Cardiovascular Pharmacodynamics of Propranolol During Ether Anaesthesia in Man , 1966, Acta anaesthesiologica Scandinavica. Supplementum.

[20]  N. Craythorne,et al.  Effects of Propranolol on the Cardiovascular Response to Cyclopropane and Halothane , 1966, Anesthesiology.

[21]  G. R. Kelman,et al.  Nomograms for correction of blood Po2, Pco2, pH, and base excess for time and temperature. , 1966, Journal of applied physiology.