Existence and multiplicity of segregated solutions to a cell-growth contact inhibition problem

We study the Dirichlet problem for the cross-diffusion system \[ \partial_tu_i=div(a_iu_i\nabla (u_1+u_2))+f_i(u_1,u_2),\quad i=1,2,\quad a_i=const>0, \] in the cylinder $Q=\Omega\times (0,T]$. It is assumed that the functions $f_1(r,0)$, $f_2(0,s)$ are locally Lipschitz-continuous and $f_1(0,s)=0$, $f_2(r,0)=0$. It is proved that for suitable initial data $u_0$, $v_0$ the system admits segregated solutions $(u_1,u_2)$ such that $u_i\in L^{\infty}(Q)$, $u_1+u_2\in C^{0}(\overline{Q})$, $u_1+u_2>0$ and $u_1\cdot u_2=0$ everywhere in $Q$. We show that the segregated solution is not unique and derive the equation of motion of the surface $\Gamma$ which separates the parts of $Q$ where $u_1>0$, or $u_2>0$. The equation of motion of $\Gamma$ is a modification of the Darcy law in filtration theory.

[1]  Masayasu Mimura,et al.  Modeling contact inhibition of growth: Traveling waves , 2013, Networks Heterog. Media.

[2]  M. Chaplain,et al.  Mathematical modelling of the loss of tissue compression responsiveness and its role in solid tumour development. , 2006, Mathematical medicine and biology : a journal of the IMA.

[3]  S. Shmarev,et al.  Lagrangian Approach to the Study of Level Sets: Application to a Free Boundary Problem in Climatology , 2009 .

[4]  Masayasu Mimura,et al.  A free boundary problem arising in a simplified tumour growth model of contact inhibition , 2010 .

[5]  M E Gurtin,et al.  On interacting populations that disperse to avoid crowding: preservation of segregation , 1985, Journal of mathematical biology.

[6]  Sergei I. Shmarev,et al.  Interfaces in multidimensional diffusion equations with absorption terms , 2003 .

[7]  S. Shmarev,et al.  Lagrangian approach to the study of level sets II: A quasilinear equation in climatology , 2009 .

[8]  Sergei I. Shmarev,et al.  Interfaces in Solutions of Diffusion-absorption Equations in Arbitrary Space Dimension , 2005 .

[9]  O. A. Ladyzhenskai︠a︡,et al.  Linear and quasilinear elliptic equations , 1968 .

[10]  Gonzalo Galiano,et al.  On a cross-diffusion segregation problem arising from a model of interacting particles , 2013, 1311.3276.

[11]  J. Vázquez,et al.  The regularity of solutions of reaction-diffusion equations via Lagrangian coordinates , 1996 .

[12]  Hermano Frid,et al.  Divergence‐Measure Fields and Hyperbolic Conservation Laws , 1999 .

[13]  C C Travis,et al.  Epidemic models with spatial spread due to population migration , 1983, Journal of mathematical biology.

[14]  Danielle Hilhorst,et al.  A NONLINEAR PARABOLIC-HYPERBOLIC SYSTEM FOR CONTACT INHIBITION OF CELL-GROWTH , 2012 .

[15]  P. Grisvard Elliptic Problems in Nonsmooth Domains , 1985 .

[16]  Morton E. Gurtin,et al.  A note on interacting populations that disperse to avoid crowding , 1984 .