Laser Acceleration of Ions for Radiation Therapy

Ion beam therapy for cancer has proven to be a successful clinical approach, affording as good a cure as surgery and a higher quality of life. However, the ion beam therapy installation is large and expensive, limiting its availability for public benefit. One of the hurdles is to make the accelerator more compact on the basis of conventional technology. Laser acceleration of ions represents a rapidly developing young field. The prevailing acceleration mechanism (known as target normal sheath acceleration, TNSA), however, shows severe limitations in some key elements. We now witness that a new regime of coherent acceleration of ions by laser (CAIL) has been studied to overcome many of these problems and accelerate protons and carbon ions to high energies with higher efficiencies. Emerging scaling laws indicate possible realization of an ion therapy facility with compact, cost-efficient lasers. Furthermore, dense particle bunches may allow the use of much higher collective fields, reducing the size of beam ...

[1]  T. Sokollik,et al.  Efficient ion acceleration by collective laser-driven electron dynamics with ultra-thin foil targets , 2009, 0909.2334.

[2]  G. Kraft.  [Heavy ion tumor therapy]. , 2009, Medizinische Monatsschrift fur Pharmazeuten.

[3]  D Kiefer,et al.  Radiation-pressure acceleration of ion beams driven by circularly polarized laser pulses. , 2009, Physical review letters.

[4]  Tsutomu Shimada,et al.  High-temporal contrast using low-gain optical parametric amplification. , 2009, Optics letters.

[5]  T Shimada,et al.  Enhanced laser-driven ion acceleration in the relativistic transparency regime. , 2009, Physical review letters.

[6]  V. Cherepenin,et al.  Characteristics of relativistic electron mirrors generated by an ultrashort nonadiabatic laser pulse from a nanofilm. , 2009, Physical review. E, Statistical, nonlinear, and soft matter physics.

[7]  L. Gremillet,et al.  High-quality ion beams by irradiating a nano-structured target with a petawatt laser pulse , 2009, 0906.3972.

[8]  Masakatsu Murakami,et al.  Application of laser-accelerated protons to the demonstration of DNA double-strand breaks in human cancer cells , 2009 .

[9]  M Borghesi,et al.  Stable GeV ion-beam acceleration from thin foils by circularly polarized laser pulses. , 2009, Physical review letters.

[10]  Z. Sheng,et al.  Self-organizing GeV, nanocoulomb, collimated proton beam from laser foil interaction at 7 x 10;{21} W/cm;{2}. , 2009, Physical review letters.

[11]  Z. Sheng,et al.  Enhanced collimated GeV monoenergetic ion acceleration from a shaped foil target irradiated by a circularly polarized laser pulse. , 2009, Physical review letters.

[12]  S. V. Bulanov,et al.  On the ion acceleration by high power electromagnetic waves in the radiation pressure dominated regime , 2009 .

[13]  V A Gasilov,et al.  Energy increase in multi-MeV ion acceleration in the interaction of a short pulse laser with a cluster-gas target. , 2009, Physical review letters.

[14]  Z. Sheng,et al.  Laser mode effects on the ion acceleration during circularly polarized laser pulse interaction with foil targets , 2008 .

[15]  Michael Geissler,et al.  Ion acceleration with ultra-thin foils using elliptically polarized laser pulses , 2008 .

[16]  Daniel Jung,et al.  Dense laser-driven electron sheets as relativistic mirrors for coherent production of brilliant X-ray and γ-ray beams , 2008 .

[17]  R. Loch,et al.  Fast-ion energy-flux enhancement from ultrathin foils irradiated by intense and high-contrast short laser pulses. , 2008, Physical review letters.

[18]  M. Lontano,et al.  Theory of light-ion acceleration driven by a strong charge separation. , 2008, Physical review letters.

[19]  J. Fang,et al.  Mono-Energetic Proton Beam Acceleration in Laser Foil-Plasma Interactions , 2008 .

[20]  Z. Sheng,et al.  Generation of High-Current Proton Beams With a Low Energy Spread by Phase-Stable Acceleration (PSA) , 2008, IEEE Transactions on Plasma Science.

[21]  S. V. Bulanov,et al.  Radiotherapy using a laser proton accelerator , 2008, 0804.3826.

[22]  Z. Sheng,et al.  Generating high-current monoenergetic proton beams by a circularly polarized laser pulse in the phase-stable acceleration regime. , 2008, Physical review letters.

[23]  Jiri Limpouch,et al.  Monoenergetic ion beams from ultrathin foils irradiated by ultrahigh-contrast circularly polarized laser pulses , 2008 .

[24]  K Nemoto,et al.  Laser ion acceleration via control of the near-critical density target. , 2008, Physical review. E, Statistical, nonlinear, and soft matter physics.

[25]  B. Shen,et al.  Efficient GeV ion generation by ultraintense circularly polarized laser pulse , 2007 .

[26]  C. Rhodes,et al.  Temperature enhancement of Xe(L) x-ray amplifier (λ ∼ 2.9 Å) emission , 2007 .

[27]  D. Neely,et al.  Low- and medium-mass ion acceleration driven by petawatt laser plasma interactions , 2007 .

[28]  F. Réau,et al.  Proton acceleration with high-intensity ultrahigh-contrast laser pulses. , 2007, Physical review letters.

[29]  P. Norreys,et al.  Dynamic control of laser-produced proton beams. , 2007, Physical review letters.

[30]  M. Abe.  Charged particle radiotherapy at the Hyogo Ion Beam Medical Center: Characteristics, technology and clinical results , 2007, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

[31]  R. G. Evans,et al.  Radiation pressure acceleration of thin foils with circularly polarized laser pulses , 2007, 0708.2040.

[32]  F. Pegoraro,et al.  Photon bubbles and ion acceleration in a plasma dominated by the radiation pressure of an electromagnetic pulse. , 2007, Physical review letters.

[33]  Xiangyang Song,et al.  Double optimization of Xe(L) amplifier power scaling at λ ∼ 2.9 Å , 2007 .

[34]  Brian James Albright,et al.  Monoenergetic and GeV ion acceleration from the laser breakout afterburner using ultrathin targets , 2007 .

[35]  O. Bunk,et al.  Hard x-ray phase tomography with low-brilliance sources. , 2007, Physical review letters.

[36]  G. Kraft.  Impact & Applications: Heavy Ion Tumor Therapy - From the Scientific Principles to the Clinical Routine , 2007 .

[37]  David Neely,et al.  Scaling of proton acceleration driven by petawatt-laser-plasma interactions , 2007 .

[38]  S. Ter-Avetisyan,et al.  Analytical model for ion acceleration by high-intensity laser pulses. , 2006, Physical review letters.

[39]  Patrick Audebert,et al.  Ultrafast Laser-Driven Microlens to Focus and Energy-Select Mega-Electron Volt Protons , 2006, Science.

[40]  T. Sokollik,et al.  Quasimonoenergetic deuteron bursts produced by ultraintense laser pulses. , 2006, Physical review letters.

[41]  O. Bunk,et al.  Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sources , 2006 .

[42]  P. Shukla,et al.  Nonlinear collective effects in photon-photon and photon-plasma interactions , 2006, hep-ph/0602123.

[43]  K.-U. Amthor,et al.  Laser-plasma acceleration of quasi-monoenergetic protons from microstructured targets , 2006, Nature.

[44]  P. Audebert,et al.  Laser-driven proton scaling laws and new paths towards energy increase , 2006 .

[45]  P. Mora.  Thin-foil expansion into a vacuum. , 2005, Physical review. E, Statistical, nonlinear, and soft matter physics.

[46]  T. Esirkepov,et al.  Laser ion-acceleration scaling laws seen in multiparametric particle-in-cell simulations. , 2005, Physical review letters.

[47]  O Jäkel,et al.  The Heidelberg Ion Therapy Center. , 2004, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[48]  A. Macchi,et al.  Laser acceleration of ion bunches at the front surface of overdense plasmas. , 2004, Physical review letters.

[49]  S. V. Bulanov,et al.  Highly efficient relativistic-ion generation in the laser-piston regime. , 2004, Physical review letters.

[50]  V. Tikhonchuk,et al.  Charge separation effects in solid targets and ion acceleration with a two-temperature electron distribution. , 2004, Physical review. E, Statistical, nonlinear, and soft matter physics.

[51]  S. V. Bulanov,et al.  Energetic protons from a few-micron metallic foil evaporated by an intense laser pulse. , 2003, Physical review letters.

[52]  Julien Fuchs,et al.  Proton spectra from ultraintense laser-plasma interaction with thin foils: Experiments, theory, and simulation , 2003 .

[53]  J S Li,et al.  Particle selection for laser-accelerated proton therapy feasibility study. , 2003, Medical physics.

[54]  P. Mora,et al.  Plasma expansion into a vacuum. , 2003, Physical review letters.

[55]  Edward B. Clark,et al.  Experimental study of proton emission from 60-fs, 200-mJ high-repetition-rate tabletop-laser pulses interacting with solid targets. , 2003, Physical review. E, Statistical, nonlinear, and soft matter physics.

[56]  S. V. Bulanov,et al.  Feasibility of using laser ion accelerators in proton therapy , 2002 .

[57]  J. Meyer-ter-Vehn,et al.  Laser wake field acceleration: the highly non-linear broken-wave regime , 2002 .

[58]  T. C. Sangster,et al.  Intense electron and proton beams from PetaWatt laser–matter interactions , 2000 .

[59]  T. C. Sangster,et al.  Intense high-energy proton beams from Petawatt-laser irradiation of solids. , 2000, Physical review letters.

[60]  Gu,et al.  Forward ion acceleration in thin films driven by a high-intensity laser , 2000, Physical review letters.

[61]  Michael D. Perry,et al.  Electron, photon, and ion beams from the relativistic interaction of Petawatt laser pulses with solid targets , 2000 .

[62]  Deanna M. Pennington,et al.  Energetic proton generation in ultra-intense laser–solid interactions , 2000 .

[63]  Alexander Wu Chao,et al.  Handbook of Accelerator Physics and Engineering: (3rd Printing) , 1999 .

[64]  Francesco Pegoraro,et al.  Nonlinear electrodynamics of the interaction of ultra-intense laser pulses with a thin foil , 1998 .

[65]  T. Tajima,et al.  Strongly nonlinear magnetosonic waves and ion acceleration , 1997 .

[66]  M. Grieser,et al.  Electron cooling and recombination experiments with an adiabatically expanded electron beam , 1996 .

[67]  Eric Esarey,et al.  Trapping and acceleration in nonlinear plasma waves , 1995 .

[68]  Brunel.  Not-so-resonant, resonant absorption. , 1987, Physical review letters.

[69]  T. Tajima,et al.  Collective ion acceleration by a reflexing electron beam: model and scaling. Memorandum report , 1983 .

[70]  T. Tajima,et al.  Laser Electron Accelerator , 1979 .

[71]  T. M. O'Neil,et al.  The Collisionless Damping of Nonlinear Plasma Oscillations. , 1965 .

[72]  C. Belka,et al.  Quantitative Cell Kill of Radio- and Chemotherapy , 2009 .

[73]  Y. Kishimoto,et al.  Strong Coupling between Clusters and Radiation , 2000 .