Recent pharmacological studies on natural products in China.

[1]  M. Beppu,et al.  Triptolide, an active compound identified in a traditional Chinese herb, induces apoptosis of rheumatoid synovial fibroblasts , 2004, BMC Pharmacology.

[2]  K. Tang,et al.  Mechanism of (-)clausenamide induced calcium transient in primary culture of rat cortical neurons. , 2004, Life sciences.

[3]  Hualiang Jiang,et al.  Progress in clinical, pharmacological, chemical and structural biological studies of huperzine A: a drug of traditional chinese medicine origin for the treatment of Alzheimer's disease. , 2003, Current medicinal chemistry.

[4]  Yadi Wu,et al.  The suppressive effect of triptolide on experimental autoimmune uveoretinitis by down-regulating Th1-type response. , 2003, International immunopharmacology.

[5]  J. A. Ross,et al.  PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy. , 2003, Molecular cancer therapeutics.

[6]  Xiao-Liang Wang,et al.  Effects of chiral 3-n-butylphthalide on apoptosis induced by transient focal cerebral ischemia in rats. , 2003, Acta pharmacologica Sinica.

[7]  B. Ahlemeyer,et al.  Pharmacological Studies Supporting the Therapeutic Use of Ginkgo biloba Extract for Alzheimer’s Disease , 2003, Pharmacopsychiatry.

[8]  A. Zangara.  The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease , 2003, Pharmacology Biochemistry and Behavior.

[9]  H. Zhang,et al.  Huperzine A attenuates the neurotoxic effect of staurosporine in primary rat cortical neurons , 2003, Neuroscience Letters.

[10]  Xiao-chao Ma,et al.  Acute effects of huperzine A and tacrine on rat liver. , 2003, Acta pharmacologica Sinica.

[11]  Xiaochao Ma,et al.  Identification of cytochrome P450 1A2 as enzyme involved in the microsomal metabolism of Huperzine A. , 2003, European journal of pharmacology.

[12]  Chuan-jiang Zhu,et al.  Stereoselective pharmacokinetics of clausenamide enantiomers and their major metabolites after single intravenous and oral administration to rats. , 2003, Chirality.

[13]  Chuan-jiang Zhu,et al.  Identification of rat cytochrome P450 forms involved in the metabolism of clausenamide enantiomers. , 2003, Chirality.

[14]  X. Tang,et al.  Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine. , 2002, European journal of pharmacology.

[15]  Xiao-yu Li,et al.  Ginkgolide A, B, and huperzine A inhibit nitric oxide-induced neurotoxicity. , 2002, International immunopharmacology.

[16]  Jin Zhou,et al.  Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia–ischemia , 2002, Brain Research.

[17]  Jin Zhou,et al.  Huperzine A attenuates apoptosis and mitochondria‐dependent caspase‐3 in rat cortical neurons , 2002, FEBS letters.

[18]  Zhenxin Zhang,et al.  [Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial]. , 2002, Zhonghua yi xue za zhi.

[19]  K. Tang,et al.  The effects of (-)clausenamide on functional recovery in transient focal cerebral ischemia , 2002, Neurological research.

[20]  Zhi-Hong Liu,et al.  Inhibition of vascular endothelial growth factor expression and production by triptolide. , 2002, Planta medica.

[21]  D. Bai,et al.  Stereoselectivities of enantiomers of huperzine A in protection against β-amyloid25–35-induced injury in PC12 and NG108-15 cells and cholinesterase inhibition in mice , 2002, Neuroscience Letters.

[22]  C. Ballard,et al.  Advances in the Treatment of Alzheimer’s Disease: Benefits of Dual Cholinesterase Inhibition , 2002, European Neurology.

[23]  H. Zhang,et al.  Huperzine A attenuates amyloid β‐peptide fragment 25‐35‐induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase‐3 activation , 2002, Journal of neuroscience research.

[24]  Yu Fu,et al.  (-)-Stepholidine: a potential novel antipsychotic drug with dual D1 receptor agonist and D2 receptor antagonist actions. , 2002, Trends in pharmacological sciences.

[25]  J. Cai,et al.  Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys. , 2001, European journal of pharmacology.

[26]  H. Zhang,et al.  Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils , 2001, Neuroscience Letters.

[27]  T. Sato,et al.  Triptolide, a novel diterpenoid triepoxide from Tripterygium wilfordii Hook. f., suppresses the production and gene expression of pro-matrix metalloproteinases 1 and 3 and augments those of tissue inhibitors of metalloproteinases 1 and 2 in human synovial fibroblasts. , 2001, Arthritis and rheumatism.

[28]  Z. Liu,et al.  [Triptolide inhibits vascular endothelial growth factor expression and production by endothelial cells]. , 2001, Zhonghua yi xue za zhi.

[29]  X. Tang,et al.  Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by beta-amyloid protein-(1-40) in rat. , 2001, European journal of pharmacology.

[30]  Xu Hl,et al.  [Effects of 3-n-butylphthalide on thrombosis formation and platelet function in rats] , 2001 .

[31]  J. A. Ross,et al.  Triptolide and Chemotherapy Cooperate in Tumor Cell Apoptosis , 2001, The Journal of Biological Chemistry.

[32]  G. Berry,et al.  Triptolide attenuates pulmonary arterial hypertension and neointimal formation in rats. , 2000, American journal of respiratory and critical care medicine.

[33]  K. Goa,et al.  Galantamine: a review of its use in Alzheimer's disease. , 2000, Drugs.

[34]  P. Kao,et al.  Anti-inflammatory effects of triptolide in human bronchial epithelial cells. , 2000, American journal of physiology. Lung cellular and molecular physiology.

[35]  F. M. Tang,et al.  Relevance between striatal expression of Fos, proenkephalin mRNA, prodynorphin mRNA and rotation induced by l-stepholidine in 6-hydroxydopamine-lesioned rats. , 2000, Acta pharmacologica Sinica.

[36]  Rui Wang,et al.  Huperzine A and tacrine attenuate β‐amyloid peptide‐induced oxidative injury , 2000 .

[37]  G. Hu,et al.  Modulation of medical prefrontal cortical D1 receptors on the excitatory firing activity of nucleus accumbens neurons elicited by (-)-Stepholidine. , 2000, Life sciences.

[38]  G. Jin,et al.  I-stepholidine facilitates inhibition of mPFC DA receptors on subcortical NAc DA release. , 2000, Acta pharmacologica Sinica.

[39]  Rui Wang,et al.  Protective effects of huperzine A on β-amyloid25–35 induced oxidative injury in rat pheochromocytoma cells , 2000, Neuroscience Letters.

[40]  L. Zhou,et al.  Reactive oxygen species-induced apoptosis in PC12 cells and protective effect of bilobalide. , 2000, The Journal of pharmacology and experimental therapeutics.

[41]  W. Song,et al.  Protective effect of bilobalide against nitric oxide-induced neurotoxicity in PC12 cells. , 2000, Acta pharmacologica Sinica.

[42]  G. Hu,et al.  Electrophysiological study on biphasic firing activity elicited by D(1) agonistic-D(2) antagonistic action of (-)-stepholidine in nucleus accumbens. , 2000, Sheng li xue bao : [Acta physiologica Sinica].

[43]  D. Bai,et al.  Huperzine A, a potential therapeutic agent for treatment of Alzheimer's disease. , 2000, Current medicinal chemistry.

[44]  X. Jie.  THE PROTECTIVE EFFECT OF BUTYLPHTHALIDE AGAINST MITOCHONDRIAL INJURY DURING CEREBRAL ISCHEMIA , 2000 .

[45]  Jian Yang,et al.  Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury , 1999, Neuroscience Letters.

[46]  H. Xu,et al.  Effects of 3-n-butylphthalide on production of vasoactive substances by cerebral and aortic endothelial cells. , 1999, Zhongguo yao li xue bao = Acta pharmacologica Sinica.

[47]  J. Kohlmeier,et al.  Triptolide is more effective in preventing T cell proliferation and interferon‐gamma production than is FK506 , 1999, Phytotherapy research : PTR.

[48]  Y. Feng,et al.  dl-3-n-butylphthalide attenuates reperfusion-induced blood-brain barrier damage after focal cerebral ischemia in rats. , 1999, Zhongguo yao li xue bao = Acta pharmacologica Sinica.

[49]  H. Koyanagi,et al.  Immunosuppressive effect of triptolide in vitro. , 1999, Transplantation proceedings.

[50]  Su Qq,et al.  Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. , 1999 .

[51]  Xing-zu Zhu,et al.  Involvement of monoamine oxidase inhibition in neuroprotective and neurorestorative effects of Ginkgo biloba extract against MPTP-induced nigrostriatal dopaminergic toxicity in C57 mice. , 1999, Life sciences.

[52]  G. Rosen,et al.  PG490 (Triptolide) Cooperates with Tumor Necrosis Factor-α to Induce Apoptosis in Tumor Cells* , 1999, The Journal of Biological Chemistry.

[53]  P. Kao,et al.  Immunosuppressant PG490 (Triptolide) Inhibits T-cell Interleukin-2 Expression at the Level of Purine-box/Nuclear Factor of Activated T-cells and NF-κB Transcriptional Activation* , 1999, The Journal of Biological Chemistry.

[54]  B. Ahlemeyer,et al.  Inhibition of serum deprivation- and staurosporine-induced neuronal apoptosis by Ginkgo biloba extract and some of its constituents. , 1999, European journal of pharmacology.

[55]  J. Cai,et al.  Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment. , 1999, The Journal of pharmacology and experimental therapeutics.

[56]  Y. Feng,et al.  Protective effects of dl-3-n-butylphthalide on changes of regional cerebral blood flow and blood-brain barrier damage following experimental subarachnoid hemorrhage. , 1998, Chinese medical journal.

[57]  Y. Yang,et al.  Triptolide induces apoptotic death of T lymphocyte. , 1998, Immunopharmacology.

[58]  X. Tang,et al.  Comparative Studies of Huperzine A, E2020, and Tacrine on Behavior and Cholinesterase Activities , 1998, Pharmacology Biochemistry and Behavior.

[59]  C. Yan,et al.  [Effects of d-3-n-butylphthalide and l-3-n-butylphthalide on extracellular no level and intracellular cGMP level in primary cultured rat cortical neurons]. , 1998, Yao xue xue bao = Acta pharmaceutica Sinica.

[60]  C. Yan,et al.  Effects of dl-3-n-butylphthalide on regional cerebral blood flow in right middle cerebral artery occlusion rats. , 1998, Zhongguo yao li xue bao = Acta pharmacologica Sinica.

[61]  X. Tang,et al.  Anticholinesterase effects of huperzine A, E2020, and tacrine in rats. , 1998, Zhongguo yao li xue bao = Acta pharmacologica Sinica.

[62]  J. Zhang,et al.  [Effects of (-), (+)clausenamide on anisodine-induced acetylcholine decrease and associated memory deficits in the mouse brain]. , 1998, Yao xue xue bao = Acta pharmaceutica Sinica.

[63]  P. Lipsky,et al.  Effects of Tripterygium wilfordii hook F extracts on induction of cyclooxygenase 2 activity and prostaglandin E2 production. , 1998, Arthritis and rheumatism.

[64]  M. Mesulam,et al.  Butyrylcholinesterase in the life cycle of amyloid plaques , 1997, Annals of neurology.

[65]  R. Ihl,et al.  Clinical efficacy of Ginkgo biloba special extract EGb 761 in dementia of the Alzheimer type. , 1997, Journal of psychiatric research.

[66]  H. Hatanaka,et al.  Changes in mitochondrial membrane potential during oxidative stress‐induced apoptosis in PC12 cells , 1997, Journal of neuroscience research.

[67]  Turan M. Itil,et al.  A Placebo-Controlled, Double-blind, Randomized Trial of an Extract of Ginkgo Biloba for Dementia , 1997 .

[68]  A. Schatzberg,et al.  A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group. , 1997, JAMA.

[69]  W. Deng,et al.  Effect of dl-3-n-butylphthalide on brain edema in rats subjected to focal cerebral ischemia. , 1997, Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih.

[70]  D. Butterfield.  beta-Amyloid-associated free radical oxidative stress and neurotoxicity: implications for Alzheimer's disease. , 1997, Chemical research in toxicology.

[71]  T. Ikeuchi,et al.  Generation of free radicals during lipid hydroperoxide-triggered apoptosis in PC12h cells , 1997 .

[72]  J. Dave,et al.  Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate , 1997, Neuroreport.

[73]  J. Pezzuto,et al.  Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii. , 1997, Cancer letters.

[74]  Y. Jun.  Immunosuppression of triptolide on skin allograft in mice , 1997 .

[75]  X. Tang,et al.  Huperzine A, a novel promising acetylcholinesterase inhibitor , 1996, Neuroreport.

[76]  X. Tang.  Huperzine A (shuangyiping): a promising drug for Alzheimer's disease. , 1996, Zhongguo yao li xue bao = Acta pharmacologica Sinica.

[77]  Paul F. Smith,et al.  The neuroprotective properties of the Ginkgo biloba leaf: a review of the possible relationship to platelet-activating factor (PAF). , 1996, Journal of ethnopharmacology.

[78]  Y. Feng,et al.  [Effect of dl-3-n-butylphthalide (NBP) on life span and neurological deficit in SHRsp rats]. , 1996, Yao xue xue bao = Acta pharmaceutica Sinica.

[79]  Y. Feng,et al.  [Protective effect of dl-3-n-butylphthalide on ischemic neurological damage and abnormal behavior in rats subjected to focal ischemia]. , 1995, Yao xue xue bao = Acta pharmaceutica Sinica.

[80]  I. Reynolds,et al.  Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[81]  P. Henrich-Noack,et al.  Neuroprotective effects of Ginkgo biloba constituents , 1995 .

[82]  Eugene M. Johnson,et al.  Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death , 1995, Neuron.

[83]  G. Jin,et al.  Effects of (-)-stepholidine on firing activity of dopamine neurons in ventral tegmental area of rats. , 1992, Zhongguo yao li xue bao = Acta pharmacologica Sinica.

[84]  Huang Kai-xing,et al.  THE ANTAGONISTIC EFFECTS OF TETRAHYDRO-PROTOBERBERINES ON DOPAMINE RECEPTORS: ELECTROPHYSIOLOGICAL STUDIES , 1992 .

[85]  Bao-cun Sun,et al.  Dual actions of (−)-stepholidine on dopamine receptor subtypes after substantia nigra lesion , 1992, Neurochemistry International.

[86]  J. Zheng.  [Screening of active anti-inflammatory, immunosuppressive and antifertility components of Tripterygium wilfordii. III. A comparison of the antiinflammatory and immunosuppressive activities of 7 diterpene lactone epoxide compounds in vivo]. , 1991, Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.

[87]  I. Adachi,et al.  Inhibitory effect of triptolide on colony formation of breast and stomach cancer cell lines. , 1991, Zhongguo yao li xue bao = Acta pharmacologica Sinica.

[88]  J. T. Zhang,et al.  [Anti-lipidperoxidation and cerebral protective effects of clausenamide]. , 1991, Yao xue xue bao = Acta pharmaceutica Sinica.

[89]  L. Pu,et al.  [Effects of triptolide on T lymphocyte functions in mice]. , 1990, Zhongguo yao li xue bao = Acta pharmacologica Sinica.

[90]  J. Krieglstein,et al.  Effects of Ginkgo biloba constituents related to protection against brain damage caused by hypoxia. , 1988, Pharmacological research communications.