Pemphigus vulgaris in two sisters.

The Ž rst patient, a 52-year-old Greek woman, was admitted to hospital 1. Park MS, Terasaki Pl, Ahmed AR, Tiwari JL. HLA-DRW4 in 91% with a great number of small,  accid vesicles on the trunk and of Jewish pemphigus vulgaris patients. Lancet 1979; 2: 441–442. numerous erosions with intense oozing on the scalp. Skin biopsy 2. Spinowitz AL, Fiedler-Weiss VC, Fu T, Solomon LM. Pemphigus showed suprabasal clefting with acantholytic cells, characteristic of vulgaris in sisters. J Am Acad Dermatol 1986; 15: 115–116. pemphigus vulgaris. Both direct and indirect immuno uorescence tests 3. Feinstein A, Yorav S, Movshovit z M, Schewach-Millet M. gave positive results for pemphigus vulgaris. Human leukocyte antigen Pemphigus in families. Int J Dermatol 1991; 30: 347–351. (HLA) typing showed the following: 9(24) 19(32) 5(51) 35 W4 , 4. Zervas J, Tosca A, Apostolakis I, Varelzidis A. HLA and pem1(6), 3(8) 4 , 6(13), W52 , W53 The patient was treated phigus. Br J Dermatol 1979; 101: 357–358. with prednisolone 75 mg/day. As the lesions regressed , the steroid 5. Laskaris G , Sklavounou A, Stavrou A, Stavropoulou K. Familial dose was gradually decreased and now the maintenance dose is 15 mg prednisolone daily. pemphigus vulgaris with oral manifestations aŒecting two Greek Her younger sister, a 45-year-old Greek woman, had also suŒered families. J Oral Pathol 1989; 18: 49–53. from pemphigus vulgaris for the last 7 years. When recalled, the 6. Reohr PB, Mangklabruks A, Janiga AM, De Groot LJ, clinical examination showed few, small erosions on her back. Skin Banjasuratwong Y, Soltani K . Pemphigus vulgaris in siblings: biopsy and immuno uorescence tests showed features consisten t with 4 and W3 and susceptibility to pemphigus. J Am pemphigus vulgaris. HLA-typing showed the following: 28 , 19(32), Acad Dermatol 1992; 27: 189–193. B16(38), B35, CW4 , DQ3(7), DQx, DR4 , DR5(11), DRW52 , DRW53 . She 7. Katzenelson V, David M, Zamir R , Mellibovsky J, Idises C, has been treated with prednisolone 40 mg/day, the dose being tapered Sandbank M. Familial pemphigus vulgaris. Dermatologica 1990; following clinical improvement . Currently, the patient is on a 181: 48–50. maintenance dose of 10 mg prednisolone daily. Sera, of both patients, were examined by the ELISA technique in 8. Starzycki Z, Chorzelsk i TP, Jablonska S. Familial pemphigus order to ascertain the antigens of pemphigus vulgaris. The ELISA vulgaris in mother and daughter . Int J Dermatol 1998; 37: 211–214. detected only desmoglein-3 in both cases.