Quantum dots and their potential applications in cancer detection and therapy

Tools are needed which can distinguish healthy from high risk populations for the early diagnosis of cancer and development of cancer control strategies. Imaging tools which may analyse the cellular profiles are non-invasive tools suitable for epidemiologic screening purposes. Quantum dots (QDs) technology fulfils the requirements of non-invasive technologies and high-throughput. Optical properties of normal cells and cancer cells are different. QDs help identify cancerous tissues and cells and follow-up of the efficacy of treatment based on the optical properties of cells. Although QD technology is still in a formative phase, it is maturing at an extremely rapid pace. Semiconductor quantum dots and nanoparticles composed of metals, lipids or polymers have emerged with promising applications for early detection and therapy of cancer. Implications of QDs in the biomedical field, especially cancer, are discussed in this article.

[1]  Zheng Gu,et al.  Green chemistry for large-scale synthesis of semiconductor quantum dots. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[2]  J. Wu,et al.  Effects of quantum confinement on the doping limit of semiconductor nanowires. , 2007, Nano letters.

[3]  R. Weissleder,et al.  Targeted delivery of multifunctional magnetic nanoparticles. , 2007, Nanomedicine.

[4]  Daniel E. Hall,et al.  Rapid and quantitative assessment of cancer treatment response using in vivo bioluminescence imaging. , 2000, Neoplasia.

[5]  Igor Nabiev,et al.  Fluorescent nanocrystal-encoded microbeads for multiplexed cancer imaging and diagnosis. , 2008, Critical reviews in oncology/hematology.

[6]  Shuming Nie,et al.  Quantum dots: emerging applications in urologic oncology. , 2008, Urologic oncology.

[7]  Noriaki Ohuchi,et al.  In vivo single molecular imaging and sentinel node navigation by nanotechnology for molecular targeting drug-delivery systems and tailor-made medicine , 2008, Breast cancer.

[8]  Lin-Wang Wang,et al.  Colloidal nanocrystal heterostructures with linear and branched topology , 2004, Nature.

[9]  R. Weissleder,et al.  Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas. , 2006, Bioconjugate chemistry.

[10]  B. Robinson,et al.  Room-temperature electron spin dynamics in free-standing ZnO quantum dots. , 2007, Physical review letters.

[11]  Yu Hua Wang,et al.  Synthesis and photoluminescence of ZnS quantum dots. , 2008, Journal of nanoscience and nanotechnology.

[12]  J. Boilot,et al.  High temperature strategy for oxide nanoparticle synthesis. , 2008, ACS nano.

[13]  M. Dahan,et al.  Interaction between water-soluble peptidic CdSe/ZnS nanocrystals and membranes: formation of hybrid vesicles and condensed lamellar phases. , 2008, Journal of the American Chemical Society.

[14]  Robert Sinclair,et al.  Improved QD-BRET conjugates for detection and imaging. , 2008, Biochemical and biophysical research communications.

[15]  Yadong Li,et al.  Preparation of CdSe quantum dots with full color emission based on a room temperature injection technique. , 2008, Inorganic chemistry.

[16]  Karolin F Meyer,et al.  Quantum dot-carrier peptide conjugates suitable for imaging and delivery applications. , 2008, Bioconjugate chemistry.

[17]  F. Romanato,et al.  Patterning of sol-gel hybrid organic-inorganic film doped with luminescent semiconductor quantum dots. , 2009, Journal of nanoscience and nanotechnology.

[18]  N. Kaji,et al.  Quantum Dots for Labeling Adipose Tissue-Derived Stem Cells , 2009, Cell transplantation.

[19]  Sailing He,et al.  Imaging pancreatic cancer using surface-functionalized quantum dots. , 2007, The journal of physical chemistry. B.

[20]  I. Texier,et al.  In vivo imaging of quantum dots. , 2009, Methods in molecular biology.

[21]  M. Gundersen,et al.  pH-sensitive Photoluminescence of CdSe/ZnSe/ZnS Quantum Dots in Human Ovarian Cancer Cells. , 2007, The journal of physical chemistry. C, Nanomaterials and interfaces.

[22]  Yi Zhang,et al.  MS-qFRET: a quantum dot-based method for analysis of DNA methylation. , 2009, Genome research.

[23]  Mehmet R Dokmeci,et al.  Toxicity of CdSe Nanoparticles in Caco-2 Cell Cultures , 2008, Journal of nanobiotechnology.

[24]  R. Weissleder Scaling down imaging: molecular mapping of cancer in mice , 2002, Nature Reviews Cancer.

[25]  M. Fromm,et al.  Functionalized silicon quantum dots tailored for targeted siRNA delivery. , 2009, Biochemical and biophysical research communications.

[26]  C. Contag,et al.  It's not just about anatomy: In vivo bioluminescence imaging as an eyepiece into biology , 2002, Journal of magnetic resonance imaging : JMRI.

[27]  H. Higuchi,et al.  Intracellular imaging of targeted proteins labeled with quantum dots. , 2008, Experimental cell research.

[28]  Yuesi Wang,et al.  Intracellular oxidative stress and cadmium ions release induce cytotoxicity of unmodified cadmium sulfide quantum dots. , 2009, Toxicology in vitro : an international journal published in association with BIBRA.

[29]  Bong Hyun Chung,et al.  Quantum dot‐based protein micro‐ and nanoarrays for detection of prostate cancer biomarkers , 2008, Proteomics.

[30]  Casey K. Chan,et al.  The dose effect of human bone marrow-derived mesenchymal stem cells on epidermal development in organotypic co-culture. , 2009, Journal of dermatological science.

[31]  I. Ishikawa,et al.  Intracellular delivery of nanogel-quantum dot hybrid nanoparticles into human periodontal ligament cells. , 2007, Drug metabolism letters.

[32]  M. Mimeault,et al.  Recent progress on normal and malignant pancreatic stem/progenitor cell research: therapeutic implications for the treatment of type 1 or 2 diabetes mellitus and aggressive pancreatic cancer , 2008, Gut.

[33]  M. Gundersen,et al.  Receptor-targeted quantum dots: fluorescent probes for brain tumor diagnosis. , 2007, Journal of biomedical optics.

[34]  Chun-Yen Chen,et al.  Type-II CdSe/CdTe/ZnTe (core-shell-shell) quantum dots with cascade band edges: the separation of electron (at CdSe) and hole (at ZnTe) by the CdTe layer. , 2005, Small.

[35]  Brad A. Kairdolf,et al.  One-pot synthesis, encapsulation, and solubilization of size-tuned quantum dots with amphiphilic multidentate ligands. , 2008, Journal of the American Chemical Society.

[36]  John V Frangioni,et al.  Size series of small indium arsenide-zinc selenide core-shell nanocrystals and their application to in vivo imaging. , 2006, Journal of the American Chemical Society.

[37]  Yoshinobu Baba,et al.  Structure-property correlation of CdSe clusters using experimental results and first-principles DFT calculations. , 2006, Journal of the American Chemical Society.

[38]  Feng Jiang,et al.  Detecting genomic aberrations by fluorescence in situ hybridization with quantum dots-labeled probes. , 2007, Journal of nanoscience and nanotechnology.

[39]  W. Chan,et al.  Cytotoxic Effects of CdSe Quantum Dots on Maturation of Mouse Oocytes, Fertilization, and Fetal Development , 2009, International journal of molecular sciences.

[40]  A. Dzurak,et al.  Gate-defined quantum dots in intrinsic silicon. , 2007, Nano letters.

[41]  Erkki Ruoslahti,et al.  Targeted quantum dot conjugates for siRNA delivery. , 2007, Bioconjugate chemistry.

[42]  Yuri Volkov,et al.  High-content screening as a universal tool for fingerprinting of cytotoxicity of nanoparticles. , 2008, ACS nano.

[43]  Q. Zeng,et al.  Highly luminescent CdSe/ZnSe core-shell quantum dots of one-pot preparation in octadecene. , 2008, Journal of nanoscience and nanotechnology.

[44]  D. Pang,et al.  The biocompatibility of quantum dot probes used for the targeted imaging of hepatocellular carcinoma metastasis. , 2008, Biomaterials.

[45]  S. Valiyaveettil,et al.  Multicolored carbon nanotubes: decorating patterned carbon nanotube microstructures with quantum dots. , 2008, ACS Nano.

[46]  Ralph Weissleder,et al.  Emerging concepts in molecular MRI. , 2007, Current opinion in biotechnology.

[47]  E. Tholouli,et al.  Quantum dots light up pathology , 2008, The Journal of pathology.

[48]  Lily Yang,et al.  Multiplexed fluorescence imaging of tumor biomarkers in gene expression and protein levels for personalized and predictive medicine. , 2009, Current molecular medicine.

[49]  Sami Kilpinen,et al.  High‐resolution copy number and gene expression microarray analyses of head and neck squamous cell carcinoma cell lines of tongue and larynx , 2008, Genes, chromosomes & cancer.

[50]  Dai-Wen Pang,et al.  Quantum dots-based immunofluorescence technology for the quantitative determination of HER2 expression in breast cancer. , 2009, Biomaterials.

[51]  Sangeeta N. Bhatia,et al.  The European charter for counteracting obesity: A late but important step towards action. Observations on the WHO-Europe ministerial conference, Istanbul, November 15–17, 2006 , 2007, The international journal of behavioral nutrition and physical activity.

[52]  F. Mannello,et al.  Protein profile ana lysis of the breast microenvironment to differentiate healthy women from breast cancer patients , 2009, Expert review of proteomics.

[53]  Laura Marcu,et al.  Quantum dot labeling and tracking of human leukemic, bone marrow and cord blood cells. , 2007, Leukemia research.

[54]  Jianghong Rao,et al.  Quantum dot bioconjugates for in vitro diagnostics & in vivo imaging. , 2008, Cancer biomarkers : section A of Disease markers.

[55]  Frank Emmrich,et al.  Quantum dots for human mesenchymal stem cells labeling. A size-dependent autophagy activation. , 2006, Nano letters.

[56]  D. Reinhoudt,et al.  Reversible phase transfer of (CdSe/ZnS) quantum dots between organic and aqueous solutions. , 2009, ACS nano.

[57]  Shuming Nie,et al.  Bioconjugated quantum dots for in vivo molecular and cellular imaging. , 2008, Advanced drug delivery reviews.

[58]  Steffen Hackbarth,et al.  Long-term exposure to CdTe quantum dots causes functional impairments in live cells. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[59]  Wei Chen,et al.  Nanoparticle fluorescence based technology for biological applications. , 2008, Journal of nanoscience and nanotechnology.

[60]  Giedre Streckyte,et al.  Examination of the stability of hydrophobic (CdSe)ZnS quantum dots in the digestive tract of rats , 2008, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[61]  Z. Zhong,et al.  The fabrication and application of patterned Si(001) substrates with ordered pits via nanosphere lithography , 2009, Nanotechnology.

[62]  C. Dais,et al.  Three-dimensional Si/Ge quantum dot crystals. , 2007, Nano letters.

[63]  R. O'Regan,et al.  Inorganic nanoparticles for predictive oncology of breast cancer. , 2009, Nanomedicine.

[64]  E. Rossinyol,et al.  QDs versus Alexa: reality of promising tools for immunocytochemistry , 2009, Journal of nanobiotechnology.

[65]  Sanjiv S Gambhir,et al.  Self-illuminating quantum dot conjugates for in vivo imaging , 2006, Nature Biotechnology.

[66]  A. Zasedatelev,et al.  Oligonucleotide microchip for subtyping of influenza A virus , 2007, Influenza and other respiratory viruses.

[67]  J. Cayuela,et al.  A diagnostic biochip for the comprehensive analysis of MLL translocations in acute leukemia , 2004, Leukemia.

[68]  Joan G. Jones,et al.  Tumor microenvironment of metastasis (TMEM): a novel tissue-based assay for metastatic risk in breast cancer. , 2009, Future Oncology.

[69]  Steven C Kazmierczak,et al.  From diagnostics to therapy: prospects of quantum dots. , 2007, Clinical biochemistry.

[70]  T. Nann,et al.  Blue shift of CdSe/ZnS nanocrystal-labels upon DNA-hybridization , 2008, Journal of nanobiotechnology.

[71]  R. Weissleder,et al.  Molecular imaging of gene therapy for cancer , 2004, Gene Therapy.

[72]  L. Chung,et al.  Quantum dots-based multiplexed immunohistochemistry of protein expression in human prostate cancer cells. , 2009, European journal of histochemistry : EJH.

[73]  L. Cohn,et al.  Sentinel Lymph Node Mapping of the Gastrointestinal Tract by Using Invisible Light , 2006, Annals of Surgical Oncology.

[74]  D. Yee,et al.  Quantum dots for cancer diagnosis and therapy: biological and clinical perspectives. , 2008, Nanomedicine.

[75]  Depu Chen,et al.  Microminiaturized immunoassays using quantum dots as fluorescent label by laser confocal scanning fluorescence detection. , 2001, Journal of immunological methods.

[76]  Xiaohu Gao,et al.  Quantum dots for cancer molecular imaging. , 2009, Advances in experimental medicine and biology.

[77]  Jackie Y Ying,et al.  Synthesis of carbohydrate-conjugated nanoparticles and quantum dots. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[78]  Bing Xu,et al.  Multifunctional magnetic nanoparticles: design, synthesis, and biomedical applications. , 2009, Accounts of chemical research.

[79]  M. Bawendi,et al.  Sentinel lymph node mapping with type-II quantum dots. , 2007, Methods in molecular biology.

[80]  Kaiyang Li,et al.  Immunofluorescence detection with quantum dot bioconjugates for hepatoma in vivo. , 2007, Journal of biomedical optics.

[81]  M.D. Wang,et al.  Detecting and Quantifying Biomarkers of Risk for Colorectal Cancer Using Quantum Dots and Novel Image Analysis Algorithms , 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.

[82]  P. S. Nair,et al.  Evolutionary shape control during colloidal quantum-dot growth. , 2007, Small.

[83]  Hedi Mattoussi,et al.  Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy , 2004, Nature Medicine.

[84]  Hedi Mattoussi,et al.  Capping of CdSe–ZnS quantum dots with DHLA and subsequent conjugation with proteins , 2006, Nature Protocols.

[85]  T. Jovin,et al.  Tumor-Targeted Quantum Dots Can Help Surgeons Find Tumor Boundaries , 2009, IEEE Transactions on NanoBioscience.

[86]  Ken-Tye Yong,et al.  Biocompatible luminescent silicon quantum dots for imaging of cancer cells. , 2008, ACS nano.

[87]  Zahi A Fayad,et al.  Nanotechnology in Medical Imaging: Probe Design and Applications , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[88]  W. Tseng,et al.  Synthesis of highly fluorescent glutathione-capped Zn(x)Hg(1-x)Se quantum dot and its application for sensing copper ion. , 2009, Journal of colloid and interface science.

[89]  M A Jacobs,et al.  Molecular and functional imaging of breast cancer , 2009, NMR in biomedicine.

[90]  Nanoscale memory characterization of virus-templated semiconducting quantum dots. , 2008, ACS nano.

[91]  Ming Wang,et al.  Unmodified CdSe Quantum Dots Induce Elevation of Cytoplasmic Calcium Levels and Impairment of Functional Properties of Sodium Channels in Rat Primary Cultured Hippocampal Neurons , 2008, Environmental health perspectives.

[92]  Zhivko Zhelev,et al.  Quantum dot-conjugated hybridization probes for preliminary screening of siRNA sequences. , 2005, Journal of the American Chemical Society.

[93]  Yan Wang,et al.  Formulation, characterization, and in vitro evaluation of quantum dots loaded in poly(lactide)‐vitamin E TPGS nanoparticles for cellular and molecular imaging , 2008, Biotechnology and bioengineering.

[94]  A Paul Alivisatos,et al.  Cellular effect of high doses of silica-coated quantum dot profiled with high throughput gene expression analysis and high content cellomics measurements. , 2006, Nano letters.

[95]  B. Kang,et al.  UV-enhanced cytotoxicity of thiol-capped CdTe quantum dots in human pancreatic carcinoma cells. , 2009, Toxicology letters.

[96]  Hong Ding,et al.  MMP-9 gene silencing by a quantum dot–siRNA nanoplex delivery to maintain the integrity of the blood brain barrier , 2009, Brain Research.

[97]  T. Mihaljevic,et al.  Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping , 2004, Nature Biotechnology.

[98]  Patricia A Holden,et al.  Effects of soluble cadmium salts versus CdSe quantum dots on the growth of planktonic Pseudomonas aeruginosa. , 2009, Environmental science & technology.

[99]  Use of CdSe/ZnS luminescent quantum dots incorporated within sol-gel matrix for urea detection. , 2008, Analytica chimica acta.

[100]  John V Frangioni,et al.  Intraoperative sentinel lymph node mapping of the lung using near-infrared fluorescent quantum dots. , 2005, The Annals of thoracic surgery.

[101]  Xiaohu Gao,et al.  Quantum dot-amphipol nanocomplex for intracellular delivery and real-time imaging of siRNA. , 2008, ACS nano.

[102]  H. Fuchs,et al.  One-step controllable synthesis for high-quality ultrafine metal oxide semiconductor nanocrystals via a separated two-phase hydrolysis reaction. , 2008, Journal of the American Chemical Society.

[103]  Dansheng Song,et al.  Protein microarrays and quantum dot probes for early cancer detection. , 2007, Colloids and surfaces. B, Biointerfaces.

[104]  Zheng Gu,et al.  Microwave-mediated nonaqueous synthesis of quantum dots at moderate temperature. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[105]  Yachna Sharma,et al.  Simple quantification of multiplexed Quantum Dot staining in clinical tissue samples , 2008, 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[106]  Olivier Ferraris,et al.  Use of the DNA Flow-Thru Chip, a Three-Dimensional Biochip, for Typing and Subtyping of Influenza Viruses , 2004, Journal of Clinical Microbiology.

[107]  M. Yezhelyev,et al.  Nanoparticles as a Novel Class of Autophagy Activators , 2007, Autophagy.

[108]  Igor L. Medintz,et al.  Delivering quantum dots into cells: strategies, progress and remaining issues , 2009, Analytical and bioanalytical chemistry.

[109]  J. Rao,et al.  Semiconductor Quantum Dots for Biosensing and In Vivo Imaging , 2009, IEEE Transactions on NanoBioscience.

[110]  John S. Condeelis,et al.  Tumor Microenvironment of Metastasis in Human Breast Carcinoma: A Potential Prognostic Marker Linked to Hematogenous Dissemination , 2009, Clinical Cancer Research.