Early and Late Fusion Machine Learning on Multi-Frequency Electrical Impedance Data to Improve Radiofrequency Ablation Monitoring

Radiofrequency ablation (RFA) is a popular modality for tumor treatment. However, inexpensive real-time monitoring of RFA within multiple tissue types is still an ongoing research topic. The objective of this study is to utilize multi-frequency electrical impedance data within real-time RFA depth estimation through data fusion schemes that include non-linear machine learning (ML) models. Multi-frequency tissue complex electrical impedance measurements are used to provide input data to the data fusion schemes. Our results show that the fusion schemes significantly decrease both the spread of residuals and the mean of the residuals for depth estimation. Thus, data fusion can be a significant tool for use in improving the performance of ML-based monitoring for RFA.

[1]  Robert E. Schapire,et al.  The Boosting Approach to Machine Learning An Overview , 2003 .

[2]  Fakhri Karray,et al.  Multisensor data fusion: A review of the state-of-the-art , 2013, Inf. Fusion.

[3]  Lionel Tarassenko,et al.  Data fusion for estimating respiratory rate from a single-lead ECG , 2013, Biomed. Signal Process. Control..

[4]  Marco Brambilla,et al.  Potential advantage of studying the lymphatic drainage by sentinel node technique and SPECT-CT image fusion for pelvic irradiation of prostate cancer. , 2006, International journal of radiation oncology, biology, physics.

[5]  Kirill V. Larin,et al.  Real-time optoacoustic monitoring of temperature in tissues , 2005 .

[6]  M. Obayya,et al.  Data fusion for heart diseases classification using multi-layer feed forward neural network , 2008, 2008 International Conference on Computer Engineering & Systems.

[7]  Wei-Yin Loh,et al.  Fifty Years of Classification and Regression Trees , 2014 .

[8]  A. Sahakian,et al.  Real-time estimation of lesion depth and control of radiofrequency ablation within ex vivo animal tissues using a neural network , 2018, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[9]  P. Shankar A general statistical model for ultrasonic backscattering from tissues , 2000 .

[10]  James Llinas,et al.  An introduction to multi-sensor data fusion , 1998, ISCAS '98. Proceedings of the 1998 IEEE International Symposium on Circuits and Systems (Cat. No.98CH36187).

[11]  Vince D. Calhoun,et al.  Feature-Based Fusion of Medical Imaging Data , 2009, IEEE Transactions on Information Technology in Biomedicine.

[12]  Manuchehr Soleimani,et al.  A fast time-difference inverse solver for 3D EIT with application to lung imaging , 2016, Medical & Biological Engineering & Computing.

[13]  Thomas G. Dietterich Multiple Classifier Systems , 2000, Lecture Notes in Computer Science.

[14]  J. McGahan,et al.  Current oncologic applications of radiofrequency ablation therapies. , 2013, World journal of gastrointestinal oncology.

[15]  Erwin Bay,et al.  Three‐Dimensional Optoacoustic Monitoring of Lesion Formation in Real Time During Radiofrequency Catheter Ablation , 2015, Journal of cardiovascular electrophysiology.

[16]  Christopher L Brace,et al.  Radiofrequency and microwave ablation of the liver, lung, kidney, and bone: what are the differences? , 2009, Current problems in diagnostic radiology.

[17]  James Sayre,et al.  Effect of vessel size on creation of hepatic radiofrequency lesions in pigs: assessment of the "heat sink" effect. , 2002, AJR. American journal of roentgenology.

[18]  Li Bin,et al.  Rapid Multimodal Medical Image Registration and Fusion in 3D Conformal Radiotherapy Treatment Planning , 2010 .

[19]  Ansgar Malich,et al.  Definition of the CTV Prostate in CT and MRI by Using CT–MRI Image Fusion in IMRT Planning for Prostate Cancer , 2011, Strahlentherapie und Onkologie.

[20]  G. Passariello,et al.  Multisensor fusion for atrial and ventricular activity detection in coronary care monitoring , 1999, IEEE Transactions on Biomedical Engineering.

[21]  Bernadette Dorizzi,et al.  A pervasive multi-sensor data fusion for smart home healthcare monitoring , 2011, 2011 IEEE International Conference on Fuzzy Systems (FUZZ-IEEE 2011).

[22]  Eung Je Woo,et al.  Real‐time conductivity imaging of temperature and tissue property changes during radiofrequency ablation: An ex vivo model using weighted frequency difference , 2015, Bioelectromagnetics.

[23]  D. Dupuy,et al.  Thermal ablation of tumours: biological mechanisms and advances in therapy , 2014, Nature Reviews Cancer.

[24]  U. Tiwary,et al.  Feature level fusion of multimodal medical images in lifting wavelet transform domain , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[25]  S L Dawson,et al.  Tissue ablation with radiofrequency: effect of probe size, gauge, duration, and temperature on lesion volume. , 1995, Academic radiology.

[26]  S. Nahum Goldberg,et al.  Radiofrequency tumor ablation: principles and techniques , 2001 .

[27]  Terence Chan,et al.  Classifying Small Volumes of Tissue for Real-Time Monitoring Radiofrequency Ablation , 2019, AIME.

[28]  Cha Zhang,et al.  Ensemble Machine Learning: Methods and Applications , 2012 .

[29]  V. Cherepenin,et al.  Three-dimensional EIT imaging of breast tissues: system design and clinical testing , 2002, IEEE Transactions on Medical Imaging.

[30]  Bernhard Schölkopf,et al.  A tutorial on support vector regression , 2004, Stat. Comput..

[31]  Emre Besler,et al.  Real-time monitoring radiofrequency ablation using tree-based ensemble learning models , 2019, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[32]  S. Stättner,et al.  Thermographic real-time-monitoring of surgical radiofrequency and microwave ablation in a perfused porcine liver model , 2017, Oncology letters.

[33]  Chung-Chih Lin,et al.  Monitoring Radiofrequency Ablation Using Real-Time Ultrasound Nakagami Imaging Combined with Frequency and Temporal Compounding Techniques , 2015, PloS one.

[34]  R. Polikar,et al.  Multimodal EEG, MRI and PET data fusion for Alzheimer's disease diagnosis , 2010, 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology.

[35]  Fikret Yildiz,et al.  Prediction of laser-induced thermal damage with artificial neural networks , 2019, Laser Physics.

[36]  D. L. Hall,et al.  Mathematical Techniques in Multisensor Data Fusion , 1992 .