In vitro synergistic effect of gentamicin with the anti‐inflammatory agent diclofenac against Listeria monocytogenes

Aims:  A total of nine Listeria monocytogenes strains (seven serotypes) were studied to ascertain whether the non‐steroidal anti‐inflammatory drug diclofenac (Dc) used in combination with the conventional antilisterial antibiotic gentamicin (Gm) or ampicillin (Am) synergistically augments the efficacy of the antibiotic in vitro.

[1]  K. Mazumdar,et al.  The anti‐inflammatory drug Diclofenac retains anti‐listerial activity in vivo , 2008, Letters in applied microbiology.

[2]  D. J. Kim,et al.  In vitro efficacy of diclofenac against Listeria monocytogenes , 2008, European Journal of Clinical Microbiology & Infectious Diseases.

[3]  S. Dastidar,et al.  Activity of diclofenac used alone and in combination with streptomycin against Mycobacterium tuberculosis in mice. , 2007, International journal of antimicrobial agents.

[4]  J. Molnár,et al.  Potential management of resistant microbial infections with a novel non-antibiotic: the anti-inflammatory drug diclofenac sodium. , 2007, International journal of antimicrobial agents.

[5]  Y. Shirataki,et al.  Diclofenac in the management of E. coli urinary tract infections. , 2006, In vivo.

[6]  V. Lorian Antibiotics in laboratory medicine , 2005 .

[7]  David A Rasko,et al.  Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne pathogen Listeria monocytogenes reveal new insights into the core genome components of this species. , 2004, Nucleic acids research.

[8]  W. F. Shepherd,et al.  A clinical evaluation of diclofenac-gentamicin combination eye drops in the control of inflammation after cataract surgery. Diclofenac-Gentamicin versus Gentamicin Study Group. , 1998, Ocular immunology and inflammation.

[9]  L. Amaral,et al.  The potential management of resistant infections with non-antibiotics. , 1997, The Journal of antimicrobial chemotherapy.

[10]  Claude Carbón [Antibiotics and anti-inflammatory agents: drug interactions]. , 1990, Pathologie-biologie.

[11]  J. Waitz Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically , 1990 .