The Prostate

Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington Department of Urology, University of Washington School of Medicine, Seattle, Washington Department of Urology, Mayo Clinic, Rochester, Minnesota Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota GenomeDx Biosciences Inc, Vancouver, British Columbia, Canada Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland AnchorDx Corporation, Guangzhou, China School of Basic Medical Sciences, Southern Medical University, Guangzhou, China Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington

[1]  James Y. Dai,et al.  A four‐gene transcript score to predict metastatic‐lethal progression in men treated for localized prostate cancer: Development and validation studies , 2019 .

[2]  P. Nelson,et al.  Contribution of Adrenal Glands to Intratumor Androgens and Growth of Castration-Resistant Prostate Cancer , 2018, Clinical Cancer Research.

[3]  Zhitong Bing,et al.  Identification of Potential Key Genes Associated With the Pathogenesis and Prognosis of Gastric Cancer Based on Integrated Bioinformatics Analysis , 2018, Front. Genet..

[4]  Jia Cao,et al.  Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells. , 2018, Toxicology letters.

[5]  Michael V. Fiandalo,et al.  Inhibition of dihydrotestosterone synthesis in prostate cancer by combined frontdoor and backdoor pathway blockade , 2018, Oncotarget.

[6]  Michael D. Nyquist,et al.  Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling. , 2017, Cancer cell.

[7]  C. Magi-Galluzzi,et al.  Direct Metabolic Interrogation of Dihydrotestosterone Biosynthesis from Adrenal Precursors in Primary Prostatectomy Tissues , 2017, Clinical Cancer Research.

[8]  W. Lu,et al.  Identification and validation of a prognostic 9-genes expression signature for gastric cancer , 2017, Oncotarget.

[9]  D. Venzon,et al.  Differential Expression of OATP1B3 Mediates Unconjugated Testosterone Influx , 2017, Molecular Cancer Research.

[10]  P. Nelson,et al.  Gene expression panel predicts metastatic‐lethal prostate cancer outcomes in men diagnosed with clinically localized prostate cancer , 2016, Molecular oncology.

[11]  W. Banks,et al.  Role of OATP Transporters in Steroid Uptake by Prostate Cancer Cells in Vivo , 2016, Prostate Cancer and Prostatic Diseases.

[12]  C. Röcken,et al.  Troy is expressed in human stomach mucosa and a novel putative prognostic marker of intestinal type gastric cancer , 2016, Oncotarget.

[13]  S. Plymate,et al.  Classical and Non-Classical Roles for Pre-Receptor Control of DHT Metabolism in Prostate Cancer Progression , 2016, Hormones and Cancer.

[14]  M. Cooperberg,et al.  Genomic Predictors of Outcome in Prostate Cancer. , 2015, European urology.

[15]  Nan Zhang,et al.  A Biopsy-based 17-gene Genomic Prostate Score Predicts Recurrence After Radical Prostatectomy and Adverse Surgical Pathology in a Racially Diverse Population of Men with Clinically Low- and Intermediate-risk Prostate Cancer. , 2015, European urology.

[16]  A. D'Amico,et al.  Which, when and why? Rational use of tissue-based molecular testing in localized prostate cancer , 2015, Prostate Cancer and Prostatic Disease.

[17]  M. Tewari,et al.  Platelet-Synthesized Testosterone in Men with Prostate Cancer Induces Androgen Receptor Signaling1 , 2015, Neoplasia.

[18]  M. Dutreix,et al.  DNA-PKcs plays role in cancer metastasis through regulation of secreted proteins involved in migration and invasion , 2015, Cell cycle.

[19]  William H. Bisson,et al.  Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor-β1 , 2015, Oncogene.

[20]  Anamaria Crisan,et al.  Combined value of validated clinical and genomic risk stratification tools for predicting prostate cancer mortality in a high-risk prostatectomy cohort. , 2015, European urology.

[21]  Xin Ma,et al.  Fibulin-1 is epigenetically down-regulated and related with bladder cancer recurrence , 2014, BMC Cancer.

[22]  P. Febbo,et al.  A 17-gene assay to predict prostate cancer aggressiveness in the context of Gleason grade heterogeneity, tumor multifocality, and biopsy undersampling. , 2014, European urology.

[23]  M. Terris,et al.  Multi-institutional validation of the CAPRA-S score to predict disease recurrence and mortality after radical prostatectomy. , 2014, European urology.

[24]  I. Haviv,et al.  Canonical Androstenedione Reduction Is the Predominant Source of Signaling Androgens in Hormone-Refractory Prostate Cancer , 2014, Clinical Cancer Research.

[25]  Anirban P. Mitra,et al.  Validation of a genomic classifier that predicts metastasis following radical prostatectomy in an at risk patient population. , 2013, The Journal of urology.

[26]  Anirban P. Mitra,et al.  Discovery and Validation of a Prostate Cancer Genomic Classifier that Predicts Early Metastasis Following Radical Prostatectomy , 2013, PloS one.

[27]  Bruno Stieger,et al.  The SLCO (former SLC21) superfamily of transporters. , 2013, Molecular aspects of medicine.

[28]  E. Kikuchi,et al.  Human castration resistant prostate cancer rather prefer to decreased 5α-reductase activity , 2013, Scientific Reports.

[29]  P. Nelson,et al.  Androgen action and metabolism in prostate cancer , 2012, Molecular and Cellular Endocrinology.

[30]  R. Bendayan,et al.  Differential Role of Organic Anion-Transporting Polypeptides in Estrone-3-Sulphate Uptake by Breast Epithelial Cells and Breast Cancer Cells , 2012, Journal of Pharmacology and Experimental Therapeutics.

[31]  J. Cuzick,et al.  Prognostic value of a cell cycle progression signature for prostate cancer death in a conservatively managed needle biopsy cohort , 2012, British Journal of Cancer.

[32]  A. Dicker,et al.  Postprostatectomy radiation therapy: an evidence-based review. , 2011, Future oncology.

[33]  M. Cooperberg,et al.  The CAPRA‐S score , 2011, Cancer.

[34]  Rui Li,et al.  Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer , 2011, Proceedings of the National Academy of Sciences.

[35]  A. Stephenson,et al.  Radiation therapy for prostate cancer after prostatectomy: adjuvant or salvage? , 2011, Nature Reviews Urology.

[36]  J. Cuzick,et al.  Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study. , 2011, The Lancet. Oncology.

[37]  Misop Han,et al.  Predicting 15-year prostate cancer specific mortality after radical prostatectomy. , 2011, The Journal of urology.

[38]  Jörg Rahnenführer,et al.  Changes in cortical cytoskeletal and extracellular matrix gene expression in prostate cancer are related to oncogenic ERG deregulation , 2010, BMC Cancer.

[39]  T. Willnow,et al.  Cellular uptake of steroid carrier proteins—Mechanisms and implications , 2010, Molecular and Cellular Endocrinology.

[40]  E. Keller,et al.  Prostate cancer stromal cells and LNCaP cells coordinately activate the androgen receptor through synthesis of testosterone and dihydrotestosterone from dehydroepiandrosterone. , 2009, Endocrine-related cancer.

[41]  R. Pöllänen,et al.  Intracrine androgenic apparatus in human bone marrow stromal cells , 2009, Journal of cellular and molecular medicine.

[42]  M. Finel,et al.  UDP-Glucuronosyltransferases (UGTs) 2B7 and UGT2B17 Display Converse Specificity in Testosterone and Epitestosterone Glucuronidation, whereas UGT2A1 Conjugates Both Androgens Similarly , 2009, Drug Metabolism and Disposition.

[43]  M. Gleave,et al.  Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer. , 2008, Cancer research.

[44]  D. Venzon,et al.  Effect of SLCO1B3 Haplotype on Testosterone Transport and Clinical Outcome in Caucasian Patients with Androgen-Independent Prostatic Cancer , 2008, Clinical Cancer Research.

[45]  P. Kantoff,et al.  Androgen receptor mediates the expression of UDP‐glucuronosyltransferase 2 B15 and B17 genes , 2008, The Prostate.

[46]  P. Nelson,et al.  Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. , 2008, Cancer research.

[47]  Y. Asmann,et al.  A Tissue Biomarker Panel Predicting Systemic Progression after PSA Recurrence Post-Definitive Prostate Cancer Therapy , 2008, PloS one.

[48]  R. Tukey,et al.  Journal of Steroid Biochemistry and Molecular Biology , 2022 .

[49]  Wolfgang A. Schulz,et al.  Downregulation of several fibulin genes in prostate cancer , 2007, The Prostate.

[50]  Olivier Barbier,et al.  UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 Enzymes Are Major Determinants of the Androgen Response in Prostate Cancer LNCaP Cells* , 2007, Journal of Biological Chemistry.

[51]  P. Nelson,et al.  Analysis of testosterone and dihydrotestosterone from biological fluids as the oxime derivatives using high-performance liquid chromatography/tandem mass spectrometry. , 2007, Rapid communications in mass spectrometry : RCM.

[52]  T. Golub,et al.  Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. , 2006, Cancer research.

[53]  H. Schulz,et al.  Role of Endocytosis in Cellular Uptake of Sex Steroids , 2005, Cell.

[54]  Alan W Partin,et al.  Risk of prostate cancer-specific mortality following biochemical recurrence after radical prostatectomy. , 2005, JAMA.

[55]  K. Tomer,et al.  Testosterone and Dihydrotestosterone Tissue Levels in Recurrent Prostate Cancer , 2005, Clinical Cancer Research.

[56]  Sarel J Fleishman,et al.  Free diffusion of steroid hormones across biomembranes: a simplex search with implicit solvent model calculations. , 2004, Biophysical journal.

[57]  Desok Kim,et al.  The Androgen Axis in Recurrent Prostate Cancer , 2004, Clinical Cancer Research.

[58]  T. Ogihara,et al.  Functional characterization of active transport of progesterone to adrenal cells , 2004, The Journal of pharmacy and pharmacology.

[59]  O. Barbier,et al.  Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans , 2003, Trends in Endocrinology & Metabolism.

[60]  Byungkook Lee,et al.  Discovery of the breast cancer gene BASE using a molecular approach to enrich for genes encoding membrane and secreted proteins , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[61]  S. Vavricka,et al.  Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver , 2002, Hepatology.

[62]  Michael W Kattan,et al.  Cancer control with radical prostatectomy alone in 1,000 consecutive patients. , 2002, The Journal of urology.

[63]  T. Visser,et al.  Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability. , 2001, Endocrine reviews.

[64]  D. Hum,et al.  Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members. , 2001, Endocrinology.

[65]  M. Namiki,et al.  ADRENAL STEROIDS IN HUMAN PROSTATIC CANCER CELL LINES , 2001, Archives of andrology.

[66]  D. Hum,et al.  Isolation and Characterization of a Novel cDNA Encoding a Human UDP-Glucuronosyltransferase Active on C19 Steroids* , 1996, The Journal of Biological Chemistry.

[67]  J. Huisman The Netherlands , 1996, The Lancet.

[68]  V. Schuster,et al.  Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates. , 1996, The American journal of physiology.

[69]  C. Guillemette,et al.  Glucuronosyltransferase activity in human cancer cell line LNCaP , 1995, Molecular and Cellular Endocrinology.

[70]  K. Miyake,et al.  Evidence for active transport of 3H-androgens across the epididymal epithelium in the rat. , 1993, Nagoya journal of medical science.

[71]  C. Tiribelli,et al.  Transport of sulfobromophthalein and taurocholate in the HepG2 cell line in relation to the expression of membrane carrier proteins. , 1992, Biochemical and biophysical research communications.

[72]  A. Roy Regulation of Steroid Hormone Action in Target Cells by Specific Hormone-Inactivating Enzymes , 1992, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[73]  F. Labrie,et al.  Steroid glucuronides: Human circulatory levels and formation by LNCaP cells , 1991, The Journal of Steroid Biochemistry and Molecular Biology.

[74]  T. Tani,et al.  Transport of steroid hormones facilitated by serum proteins. , 1991, Biochimica et biophysica acta.

[75]  A. Johnson,et al.  Metabolism of dehydroisoandrosterone and androstenedione in human pulmonary endothelial cells in culture. , 1983, The Journal of clinical endocrinology and metabolism.

[76]  G. Murphy,et al.  LNCaP model of human prostatic carcinoma. , 1983, Cancer research.

[77]  L. Milewich,et al.  Metabolism of androstenedione by human platelets: a source of potent androgens. , 1982, The Journal of clinical endocrinology and metabolism.

[78]  J. Lechner,et al.  Establishment and characterization of a human prostatic carcinoma cell line (PC-3). , 1979, Investigative urology.

[79]  B. Setchell,et al.  The Mechanism of Transport of Testosterone through the Walls of the Seminiferous Tubules of the Rat Testis , 1978 .

[80]  H. Breuer,et al.  Uptake of cortisol by isolated rat liver cells. A phenomenon indicative of carrier-mediation and simple diffusion. , 1976, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

[81]  E. Baulieu Some aspects of the mechanism of action of steroid hormones , 1975, Molecular and Cellular Biochemistry.

[82]  G. Waites,et al.  Steroid entry into rete testis fluid and the blood-testis barrier. , 1975, The Journal of endocrinology.

[83]  E. Baulieu,et al.  Studies on estrogen entry into uterine cells and on estradiol-receptor complex attachment to the nucleus--is the entry of estrogen into uterine cells a protein-mediated process? , 1973, Biochimica et biophysica acta.

[84]  H. Karl,et al.  Enzymes of androgen metabolism in human leucocytes. , 1973, Acta endocrinologica. Supplementum.

[85]  C. Huggins,et al.  Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate , 1941, CA: a cancer journal for clinicians.

[86]  L. True,et al.  Testosterone accumulation in prostate cancer cells is enhanced by facilitated diffusion. , 2019, The Prostate.

[87]  A. Jemal,et al.  Cancer statistics, 2019 , 2019, CA: a cancer journal for clinicians.

[88]  P. Nelson,et al.  Castration-resistant prostate cancer: targeting androgen metabolic pathways in recurrent disease. , 2009, Urologic oncology.

[89]  H. Lepor,et al.  Androgen deprivation therapy in the treatment of advanced prostate cancer. , 2007, Reviews in urology.

[90]  N. Palackal,et al.  Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. , 2000, The Biochemical journal.

[91]  P. Soucy,et al.  Characteristics of a highly labile human type 5 17beta-hydroxysteroid dehydrogenase. , 1999, Endocrinology.

[92]  C. Guillemette,et al.  Differential regulation of two uridine diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells. , 1997, Endocrinology.

[93]  D. Yee,et al.  Insulinlike growth factors in human malignancy. , 1991, Cancer investigation.

[94]  N. Dubrawsky Cancer statistics , 1989, CA: a cancer journal for clinicians.

[95]  L. Milewich,et al.  Androstenedione metabolism by human lymphocytes. , 1982, Journal of steroid biochemistry.

[96]  B. Setchell,et al.  The facilitated diffusion of testosterone into the rete testis of the ram [proceedings]. , 1978, The Journal of physiology.

[97]  B. Setchell,et al.  The blood - testis barrier and steroids. , 1975, Current topics in molecular endocrinology.

[98]  H. Christensen,et al.  Concentration of taurine, beta-alanine, and triiodothyronine by ascites carcinoma cells. , 1954, Cancer research.