THE INFLUENCE OF PHLORIDZIN ON THE BILE AND LYMPH

In my article on Phloridzin Glyeosuria, published in 1894,* I had in view the demonstration of two propositions: (1) That there existed no sut~cient grounds for v. Noorden's assumption that phloridzin glyeosuria does not at all resemble any forms of spontaneous diabetes mellitus, and that, therefore, the mechanism of this experimental glycosuria cannot be applied to the explanation of any clinical forms of diabetes; and (5) that the appearance of sugar in the urine in this experimental glycosuria could not be satisfactorily explained by mere elimination from the blood. Several facts had led me to doubt the " elimination theory." In the first place v. Mering himself, who examined the blood for sugar only after the injection o£ phloridzin, found that the amount of sugar did not differ much from that which occurs very often in normal dogs, and therefore could not be called subnormal. Again, the work of ~inkowski proved that after the extirpation of the kidneys and subsequent phloridzin injection there was in fact some slight increase of sugar in the blood. Lastly, Cornevin found an increase of sugar in the milk after phloridzin injection. To these facts I was able to add from my own experiments that the venous blood of the kidneys never contained less sugar than the arterial, and that the amount of sugar in the whole kidney after the phloridzin injection was higher than normal Very recently Zuntz, again recurring to the study of " phloridzin diabetes," has shown in a very ingenious way that the appearance of