Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors
暂无分享,去创建一个
D. Chaplin | B. Siim | M. L. Trawick | Amanda K. Charlton-Sevcik | K. Pinney | G. E. Chavarria | Shengwu Chen | T. Strecker | Wara M. Arispe | G. D. Kishore Kumar | Matthew T Macdonough | M. Trawick
[1] S. Steinbacher,et al. Dipeptidyl nitrile inhibitors of Cathepsin L. , 2009, Bioorganic & medicinal chemistry letters.
[2] R. Guy,et al. Antimalarial activity of thiosemicarbazones and purine derived nitriles. , 2009, Bioorganic & medicinal chemistry letters.
[3] K. Lee,et al. Cathepsin B is a target of Hedgehog signaling in pancreatic cancer. , 2009, Cancer letters.
[4] Michael C. Myers,et al. Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype. , 2008, Bioorganic & medicinal chemistry letters.
[5] A. Shelat,et al. Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. , 2008, Bioorganic & medicinal chemistry letters.
[6] R. Ménard,et al. Peptidomimetic 2-cyanopyrrolidines as potent selective cathepsin L inhibitors , 2008, Journal of enzyme inhibition and medicinal chemistry.
[7] O. Vasiljeva,et al. Emerging roles of cysteine cathepsins in disease and their potential as drug targets. , 2007, Current pharmaceutical design.
[8] Bonnie F. Sloane,et al. Cysteine cathepsins: multifunctional enzymes in cancer , 2006, Nature Reviews Cancer.
[9] Ming Zhou,et al. Design, synthesis, and biochemical evaluation of novel cruzain inhibitors with potential application in the treatment of Chagas' disease. , 2006, Bioorganic & medicinal chemistry letters.
[10] Y. Ru,et al. Azepanone-based inhibitors of human cathepsin L. , 2005, Journal of medicinal chemistry.
[11] S. Diamond,et al. Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[12] S. Whelan,et al. Endosomal Proteolysis of the Ebola Virus Glycoprotein Is Necessary for Infection , 2005, Science.
[13] J. Kos,et al. Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues. , 2005, Experimental cell research.
[14] E. Im,et al. Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells. , 2005, Molecular biology of the cell.
[15] J. Gut,et al. Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. , 2005, Bioorganic & medicinal chemistry letters.
[16] Bonnie F. Sloane,et al. Cysteine cathepsins in human cancer , 2004, Biological chemistry.
[17] D. Hanahan,et al. Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. , 2004, Cancer cell.
[18] D. Brömme,et al. Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design. , 2002, Chemical reviews.
[19] E. Purisima,et al. Design of noncovalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides. , 2002, Journal of medicinal chemistry.
[20] C. Bryant,et al. Peptidic 1-cyanopyrrolidines: synthesis and SAR of a series of potent, selective cathepsin inhibitors. , 2002, Bioorganic & medicinal chemistry.
[21] J. McKerrow,et al. Synthesis and Structure−Activity Relationship Study of Potent Trypanocidal Thio Semicarbazone Inhibitors of the Trypanosomal Cysteine Protease Cruzain , 2002 .
[22] D. Turk,et al. Lysosomal cysteine proteases: facts and opportunities , 2001, The EMBO journal.
[23] S. Rafati,et al. Identification of Leishmania major cysteine proteinases as targets of the immune response in humans. , 2001, Molecular and biochemical parasitology.
[24] J. Falgueyret,et al. Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L. , 2001, Journal of medicinal chemistry.
[25] Christian A. Rees,et al. Systematic variation in gene expression patterns in human cancer cell lines , 2000, Nature Genetics.
[26] Y. Fujisawa,et al. Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorption. , 1998, Journal of medicinal chemistry.
[27] K. Tanaka,et al. Purification and properties of a new cathepsin from rat liver. , 1978, Journal of biochemistry.
[28] A. Angulo,et al. Inhibitors of human cathepsin L and cruzain as therapeutic agents. , 2008 .
[29] Michael C. Myers,et al. Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. , 2008, Bioorganic & medicinal chemistry letters.
[30] Rogelio Siles. Design, synthesis and biological evaluation of new anti-Cancer nitrogen-containing combretastatins and novel cysteine protease inhibitors for the treatment of Chagas. , 2005 .
[31] N. Katunuma,et al. Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. , 1990, Journal of enzyme inhibition.