A Panel PET With Window: Design, Performance Evaluation, and Prototype Development

Positron emission tomography (PET) scanners with new features, such as open structure, compact size, and adaptive field of view (FOV), have attracted significant attention. Among these novel designs, panel PET has the potential to combine the open structure and variable FOV into a compact form. In this paper, we would like to further exploit these structural advantages by proposing a modified version, called the panel PET with window (PPW). A PPW is a panel PET with a rectangular opening in the center of one detector panel, which inherts the advantages of the compact size and adjustable FOV of the panel PET. Meanwhile, it utilizes fewer detector modules and offers additional flexibility and convenience in practical applications. We quantitatively evaluated the imaging performance of the PPW based on Monte Carlo simulations and real data experiments using a prototype system. The results show that the PPW system sensitivity, spatial resolution, signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) deteriorate, and the effective FOV narrows down. However, the deterioration is not linear to the increase of window size. In our extreme case with 69.4% of detectors removed from a panel, the degradation of SNR, CNR, and spatial resolution are 42.4%, 43.1%, and 25.0%, respectively. Meanwhile, the contrast recovery coefficient of PPW remains almost constant.

[1]  Yuki Shinohara,et al.  Interindividual Variations of Cerebral Blood Flow, Oxygen Delivery, and Metabolism in Relation to Hemoglobin Concentration Measured by Positron Emission Tomography in Humans , 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[2]  Jens Overgaard,et al.  Resolution in PET hypoxia imaging: Voxel size matters , 2008, Acta oncologica.

[3]  Wolfgang Enghardt,et al.  On the detector arrangement for in-beam PET for hadron therapy monitoring , 2006, Physics in medicine and biology.

[4]  Roger Fulton,et al.  Median non-local means filtering for low SNR image denoising: Application to PET with anatomical knowledge , 2010, IEEE Nuclear Science Symposuim & Medical Imaging Conference.

[5]  P. V. van Rijk,et al.  The detection of local recurrent head and neck cancer with fluroine-18 fluorodeoxyglucose dual-head positron emission tomography , 1999, European Journal of Nuclear Medicine.

[6]  W W Moses,et al.  A Multi-Threshold Sampling Method for TOF PET Signal Processing. , 2009, Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment.

[7]  Di Yan,et al.  Potential for reduced toxicity and dose escalation in the treatment of inoperable non-small-cell lung cancer: a comparison of intensity-modulated radiation therapy (IMRT), 3D conformal radiation, and elective nodal irradiation. , 2003, International journal of radiation oncology, biology, physics.

[8]  Deepa Narayanan,et al.  PET‐Guided Breast Biopsy , 2011, The breast journal.

[9]  W. Enghardt,et al.  Direct time-of-flight for quantitative, real-time in-beam PET: a concept and feasibility study , 2007, Physics in medicine and biology.

[10]  Keishi Kitamura,et al.  Performance characteristics of a new 3-dimensional continuous-emission and spiral-transmission high-sensitivity and high-resolution PET camera evaluated with the NEMA NU 2-2001 standard. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[11]  Robert M. Lewitt,et al.  Application of the row action maximum likelihood algorithm with spherical basis functions to clinical PET imaging , 2001 .

[12]  W. Moses.  Time of flight in PET revisited , 2003 .

[13]  R Freifelder,et al.  Dedicated PET scanners for breast imaging. , 1997, Physics in medicine and biology.

[14]  C. Michel,et al.  Performance of a high sensitivity PET scanner based on LSO panel detectors , 2005, IEEE Nuclear Science Symposium Conference Record, 2005.

[15]  W. Beckham,et al.  Is multibeam IMRT better than standard treatment for patients with left-sided breast cancer? , 2007, International journal of radiation oncology, biology, physics.

[16]  J. Karp,et al.  Design considerations for a limited angle, dedicated breast, TOF PET scanner , 2007, 2007 IEEE Nuclear Science Symposium Conference Record.

[17]  Q. Xie,et al.  Conceptual Design and Simulation Study of an ROI-Focused Panel-PET Scanner , 2013, PloS one.

[18]  S. Reske,et al.  Detection of liver metastases from pancreatic cancer using FDG PET. , 1999, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[19]  P. Olcott,et al.  Study of the performance of a novel 1 mm resolution dual-panel PET camera design dedicated to breast cancer imaging using Monte Carlo simulation. , 2007, Medical physics.

[20]  John R. Votaw,et al.  Optimization of PET activation studies based on the SNR measured in the 3-D Hoffman brain phantom , 1998, IEEE Transactions on Medical Imaging.

[21]  P. V. van Rijk,et al.  Preoperative evaluation of patients with primary head and neck cancer using dual-head 18fluorodeoxyglucose positron emission tomography. , 2000, Annals of surgery.

[22]  Anders Brahme,et al.  Dose prescription and treatment planning based on FMISO-PET hypoxia , 2012, Acta oncologica.

[23]  C. L. Le Rest,et al.  Validation of a Monte Carlo simulation of the Philips Allegro/GEMINI PET systems using GATE , 2006, Physics in medicine and biology.

[24]  Peng Xiao,et al.  TOF capability evaluation on a panel PET for human body imaging , 2013 .

[25]  M. Picchio,et al.  Tumour hypoxia imaging with [18F]FAZA PET in head and neck cancer patients: a pilot study , 2007, European Journal of Nuclear Medicine and Molecular Imaging.

[26]  R.R. Raylman.  Positron Emission Tomography-Guided Biopsy With a Dedicated Breast Scanner: Initial Evaluation , 2009, IEEE Transactions on Nuclear Science.

[27]  T. Jones,et al.  Can positron emission tomography (PET) be used to detect subclinical response to cancer therapy? The EC PET Oncology Concerted Action and the EORTC PET Study Group. , 1995, European journal of cancer.

[28]  Katia Parodi,et al.  Charged hadron tumour therapy monitoring by means of PET , 2004 .

[29]  Hee-Joung Kim,et al.  Assessment of Early Phase $^{18}{\rm F}$-FP-CIT PET as an Alternative Method of FDG PET for Voxel Based Statistical Analysis: Application for Parkinson's Disease Rat Model , 2013, IEEE Transactions on Nuclear Science.

[30]  Qingguo Xie,et al.  A PET system design by using mixed detectors: resolution properties , 2014, Physics in medicine and biology.

[31]  C. Kufta,et al.  Cerebral necrosis after radiotherapy and/or intraarterial chemotherapy for brain tumors: PET and neuropathologic studies. , 1987, AJR. American journal of roentgenology.

[32]  C. Perez,et al.  Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma: a comparison with conventional techniques. , 2001, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[33]  Steven G. Ross,et al.  Application and Evaluation of a Measured Spatially Variant System Model for PET Image Reconstruction , 2010, IEEE Transactions on Medical Imaging.

[34]  Chin-Tu Chen,et al.  Performance characterization of a high-sensitivity small-animal PET scanner , 2007, 2007 IEEE Nuclear Science Symposium Conference Record.

[35]  Roberta Matheoud,et al.  Performance characteristics obtained for a new 3-dimensional lutetium oxyorthosilicate-based whole-body PET/CT scanner with the National Electrical Manufacturers Association NU 2-2001 standard. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[36]  Richard S. J. Frackowiak,et al.  PET and plasma pharmacokinetic studies after bolus intravenous administration of [11C]melatonin in humans. , 1991, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

[37]  D. Townsend,et al.  Three-Dimensional Image Reconstruction for a Positron Camera with Limited Angular Acceptance , 1980, IEEE Transactions on Nuclear Science.

[38]  Chin-Tu Chen,et al.  A High-Sensitivity Small-Animal PET Scanner: Development and Initial Performance Measurements , 2009, IEEE Transactions on Nuclear Science.

[39]  K. Parodi,et al.  Suppression of random coincidences during in-beam PET measurements at ion beam radiotherapy facilities , 2005, IEEE Transactions on Nuclear Science.

[40]  Eiji Yoshida,et al.  A proposal of an open PET geometry , 2008, Physics in medicine and biology.

[41]  H. Haneishi,et al.  Performance evaluation of a transformable axial-shift type single-ring OpenPET , 2013, 2013 IEEE Nuclear Science Symposium and Medical Imaging Conference (2013 NSS/MIC).

[42]  D. Mankoff,et al.  Beyond Detection: Novel Applications for PET Imaging to Guide Cancer Therapy , 2007, Journal of Nuclear Medicine.

[43]  P Armstrong,et al.  Staging non-small cell lung cancer. , 1993, Clinical radiology.

[44]  H. Murayama,et al.  Real-Time Imaging System for the OpenPET , 2012, IEEE Transactions on Nuclear Science.

[45]  S. Pistorius,et al.  Evaluation of the Feasibility and Quantitative Accuracy of a Generalized Scatter 2D PET Reconstruction Method , 2013 .

[46]  J. Qi,et al.  Initial Results of a Positron Tomograph for Prostate Imaging , 2006, IEEE Transactions on Nuclear Science.

[47]  D. Groheux,et al.  Effect of variation in relaxation parameter value on LOR-RAMLA reconstruction of 18F-FDG PET studies , 2009, Nuclear medicine communications.

[48]  M. Mintun,et al.  Breast cancer: PET imaging of estrogen receptors. , 1988, Radiology.

[49]  J. Humm,et al.  Pharmacokinetic Assessment of the Uptake of 16β-18F-Fluoro-5α-Dihydrotestosterone (FDHT) in Prostate Tumors as Measured by PET , 2010, Journal of Nuclear Medicine.

[50]  Chin-Tu Chen,et al.  Potentials of Digitally Sampling Scintillation Pulses in Timing Determination in PET , 2009, IEEE Transactions on Nuclear Science.

[51]  J. S. Karp,et al.  Design Optimization of a Time-Of-Flight, Breast PET Scanner , 2013, IEEE Transactions on Nuclear Science.

[52]  Georges El Fakhri,et al.  Proton Therapy Verification with PET Imaging , 2013, Theranostics.

[53]  J. Daouk,et al.  A practical way to improve contrast-to-noise ratio and quantitation for statistical-based iterative reconstruction in whole-body PET imaging. , 2009, Medical physics.

[54]  Juan Manuel Górriz,et al.  NMF-SVM Based CAD Tool Applied to Functional Brain Images for the Diagnosis of Alzheimer's Disease , 2012, IEEE Transactions on Medical Imaging.

[55]  William W. Moses,et al.  Conceptual design of a high-sensitivity small animal PET camera with 4/spl pi/ coverage , 1999 .

[56]  Tetsuya Shinaji,et al.  Development of a small single-ring OpenPET prototype with a novel transformable architecture , 2016, Physics in medicine and biology.

[57]  G. Tomasi,et al.  Evaluation of Deuterated 18F- and 11C-Labeled Choline Analogs for Cancer Detection by Positron Emission Tomography , 2012, Clinical Cancer Research.

[58]  Wei Liu,et al.  FPGA-Only MVT Digitizer for TOF PET , 2013, IEEE Transactions on Nuclear Science.