Lack of Association of XRCC4 (rs1805377) and ATF6 (rs2070150) SNPs with HCC in Thai Patients with HBV Infection

Liver cancer, ranked sixth of most common sites of cancer in world population, is originated in sites of the liver. In 2012, approximately 782,000 newly diagnosed cases occurred worldwide. Besides, about 83% of liver cancer has been arisen in under developed and developing country, which results in devastation in hospitalization and economic. Previous study showed that the highest incidence of liver cancer was in Africa and Asia, the lower incidence was presented in Europe, Latin America and Carribbean (Ferlay, 2014). One of the most frequent of liver cancer is called Hepatocellular Carcinoma (HCC), a primary liver cancer which is defined by a cancer formed within hepatocytes and further become malignant. Annually, it appears that HCC is the cause of death in 500,000-600,000 liver cancer patients (Arzumanyan et al., 2013). Previous studies showed that many risk factors (both of viral and host factors) can be responsible for HCC, such as cirrhosis, aflatoxin exposure, smoking, alcohol addiction and virus infection (Nakamoto et al., 2003; Blum, 2005; Herzer et al., 2007), especially chronic hepatitis B virus infection (CHB), which has been focused

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