Differential expression of MUC1 and carbohydrate antigens in primary and secondary head and neck squamous cell carcinoma

In head and neck squamous cell carcinoma (HNSCC), tumor markers may be helpful to evaluate prognosis accurately as well as to improve therapy selection. Detection of human MUC1 has been widely employed for the evaluation of carcinoma patients. This article aims to study MUC1, Tn, sTn, and Lewis antigenic expression in primary HNSCC, lymph node metastasis, and local recurrences.

[1]  M. Price,et al.  Detection and isolation of MUC1 mucin from larynx squamous cell carcinoma , 2009, Pathology & Oncology Research.

[2]  P. Singh,et al.  Cell surface-associated mucins in signal transduction. , 2006, Trends in cell biology.

[3]  S. Gendler,et al.  MUC1 cytoplasmic tail detection using CT33 polyclonal and CT2 monoclonal antibodies in breast and colorectal tissue. , 2006, Histology and histopathology.

[4]  A. Furlan,et al.  ST6GalNAc I expression in MDA-MB-231 breast cancer cells greatly modifies their O-glycosylation pattern and enhances their tumourigenicity. , 2006, Glycobiology.

[5]  N. Smorodinsky,et al.  The MUC1 SEA Module Is a Self-cleaving Domain* , 2005, Journal of Biological Chemistry.

[6]  R. Kramer,et al.  Tumor cell invasion and survival in head and neck cancer , 2005, Cancer and Metastasis Reviews.

[7]  Lajos Döbróssy,et al.  Epidemiology of head and neck cancer: Magnitude of the problem , 2005, Cancer and Metastasis Reviews.

[8]  R. Kannagi,et al.  Carbohydrate‐mediated cell adhesion in cancer metastasis and angiogenesis , 2004, Cancer science.

[9]  Sandra J. Gendler MUC1, The Renaissance Molecule , 2001, Journal of Mammary Gland Biology and Neoplasia.

[10]  S. Gendler,et al.  Patterns of MUC1 Tissue Expression Defined by an Anti-MUC1 Cytoplasmic Tail Monoclonal Antibody in Breast Cancer , 2003, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[11]  S. Carrington,et al.  Distribution of MUC1 in the normal human oral cavity is localized to the ducts of minor salivary glands. , 2001, Archives of oral biology.

[12]  M. Pasdar,et al.  The importance of MUC1 cellular localization in patients with breast carcinoma , 2001, Cancer.

[13]  J. Wilson,et al.  Expression of MUC1 and MUC2 glycoproteins in laryngeal cancer. , 2001, Clinical otolaryngology and allied sciences.

[14]  H. L. Vos,et al.  A STAT-responsive Element in the Promoter of the Episialin/MUC1 Gene Is Involved in Its Overexpression in Carcinoma Cells* , 2001, The Journal of Biological Chemistry.

[15]  M. Duffy,et al.  CA 15–3: A Prognostic Marker in Breast Cancer , 2000, The International journal of biological markers.

[16]  F. Murata,et al.  Immunohistochemical study of MUC1 mucin in premalignant oral lesions and oral squamous cell carcinoma , 2000, Cancer.

[17]  J. Taylor‐Papadimitriou,et al.  MUC1 and cancer. , 1999, Biochimica et biophysica acta.

[18]  Seiji Nakamura,et al.  Immunohistochemical study of sialyl lea and sialyl lex antigen in oral squamous cell carcinoma: The association of sialyl lea expression with the metastatic potential , 1999 .

[19]  M. Bryne,et al.  Differences in sialyl‐Tn antigen expression between keratoacanthomas and cutaneous squamous cell carcinomas , 1999, Journal of cutaneous pathology.

[20]  M. Shinohara,et al.  Immunohistochemical study of sialyl Le(a) and sialyl Le(x) antigen in oral squamous cell carcinoma: the association of sialyl Le(a) expression with the metastatic potential. , 1999, Head & neck.

[21]  R. Scher,et al.  Identification of sialyl Lewis‐x in squamous cell carcinoma of the head and neck , 1998, Head & neck.

[22]  I. Bièche,et al.  A gene dosage effect is responsible for high overexpression of the MUC1 gene observed in human breast tumors. , 1997, Cancer genetics and cytogenetics.

[23]  M. Nomoto,et al.  Expression of mucin antigens and Lewis X‐related antigens in carcinomas and dysplasia of the pharynx and larynx , 1996, Pathology international.

[24]  M. Price,et al.  Effect of glycosylation of a synthetic MUC1 mucin-core-related peptide on recognition by anti-mucin antibodies. , 1996, Cancer letters.

[25]  Y. Tatemoto,et al.  Immunohistochemical observations on binding of monoclonal antibody to epithelial membrane antigen in epithelial tumors of the oral cavity and skin. , 1987, Oral surgery, oral medicine, and oral pathology.

[26]  J. Lund,et al.  Epithelial Membrane Antigen Expression in Benign and Malignant Squamous Epithelium of the Head and Neck , 1987, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[27]  K. Shitara,et al.  Generation of monoclonal antibodies against human lung squamous cell carcinoma and adenocarcinoma using mice rendered tolerant to normal human lung. , 1986, Cancer research.

[28]  R. W. Baldwin,et al.  Multiple epitopes on a human breast‐carcinoma‐associated antigen , 1985, International journal of cancer.

[29]  R. W. Baldwin,et al.  A monoclonal antibody against human colonic adenoma recognizes difucosylated Type-2-blood-group chains , 1983, Bioscience reports.

[30]  W. Bodmer,et al.  Monoclonal antibodies to epithelium‐specific components of the human milk fat globule membrane: Production and reaction with cells in culture , 1981, International journal of cancer.