Burn Hemangioma (BH) (Scalded Pyogenic Granuloma) versus Infantile Hemangioma: Report of Six Cases of BH and Its Effective Therapy with Oral Propranolol

Infantile hemangioma and burn hemangioma have many similarities in clinical pictures, pathology and treatment. As infantile hemangioma appears usually after birth and then rapidly grow within few months and then a statue state and then involutes within few years while burn hemangioma so called burn pyogenic granuloma usually appears within days after burn with liquid and grow rapidly into many giant angiomatous masses and then after short time usually weeks or months will involute in more than 37.5% of cases. Hence burn hemangioma and infantile hemangioma sharing many similar features as both are angiomatous with dramatic rapid proliferation of blood vessels that followed by involution but with different time periods and both carry CD133 and CD34 for infantile hemangioma and CD34 for burn hemangioma. Also infantile hemangioma rapidly responds to systemic propranolol and similarly do in cases of burn hemangioma. Accordingly it is more better scientifically to call scalded pyogenic granuloma burn hemangioma. The objective of the present report is to review these conditions and do comparison between them and also to record 6 cases of burn hemangioma and its effective therapy with oral propranolol.

[1]  R. Rapini Vascular Proliferations and Neoplasms , 2021, Practical Dermatopathology.

[2]  G. D. Hildebrand,et al.  Review of topical beta blockers as treatment for infantile hemangiomas. , 2016, Survey of ophthalmology.

[3]  Hui Li,et al.  Multiple Eruptive Pyogenic Granulomas Occurring in a Region of Scalded Skin , 2016, Pediatric dermatology.

[4]  Xiaobing Fu,et al.  Should pyogenic granulomas following burns be excised? , 2015, Burns : journal of the International Society for Burn Injuries.

[5]  Vishal Gupta,et al.  Management of Infantile Hemangiomas: Current Trends , 2014, Journal of cutaneous and aesthetic surgery.

[6]  D. Low,et al.  Treatment of Pediatric Pyogenic Granulomas Using β‐Adrenergic Receptor Antagonists , 2014, Pediatric dermatology.

[7]  M. Mihm,et al.  Vascular Neoplasms and Malformations , 2014 .

[8]  J. Mulliken Diagnosis and Natural History of Hemangiomas , 2013 .

[9]  J. Mulliken,et al.  Mulliken and Young's vascular anomalies : hemangiomas and malformations , 2013 .

[10]  S. Greenberger,et al.  Pathogenesis of infantile haemangioma , 2013, The British journal of dermatology.

[11]  U. Alabalık,et al.  Multiple disseminated pyogenic granuloma after second degree scald burn: a rare two case. , 2013, International journal of burns and trauma.

[12]  R. García-Mónaco,et al.  [Infantile hemangiomas]. , 2013, Archivos argentinos de pediatria.

[13]  T. Phung,et al.  Pathogenesis of Infantile Hemangioma , 2012, Facial Plastic Surgery.

[14]  H. Sinno,et al.  Treatment options for cutaneous pyogenic granulomas: a review. , 2011, Journal of plastic, reconstructive & aesthetic surgery : JPRAS.

[15]  Swee T Tan,et al.  Primitive mesodermal cells with a neural crest stem cell phenotype predominate proliferating infantile haemangioma , 2010, Journal of Clinical Pathology.

[16]  A. Mohammadi,et al.  Efficacy of Propranolol in Wound Healing for Hospitalized Burn Patients , 2009, Journal of burn care & research : official publication of the American Burn Association.

[17]  H. Shahidullah,et al.  Naevi and Other Developmental Defects , 2008 .

[18]  刘文敏 草莓状毛细血管瘤(Strawberry Hemangioma)治疗的研究进展 , 2008 .

[19]  A. Giblin,et al.  Pyogenic granuloma - the quest for optimum treatment: audit of treatment of 408 cases. , 2007, Journal of plastic, reconstructive & aesthetic surgery : JPRAS.

[20]  E. Pope,et al.  Topical imiquimod in the treatment of infantile hemangiomas: a retrospective study. , 2007, Journal of the American Academy of Dermatology.

[21]  H. Galvão,et al.  Assessment of angiogenic markers in oral hemangiomas and pyogenic granulomas. , 2005, Experimental and molecular pathology.

[22]  K. Yuan,et al.  The detection and comparison of angiogenesis-associated factors in pyogenic granuloma by immunohistochemistry. , 2000, Journal of periodontology.

[23]  C. Caramelo,et al.  Increased expression of vascular endothelial growth factor in pyogenic granulomas. , 1999, Acta dermato-venereologica.

[24]  N. Esterly Cutaneous hemangiomas, vascular stains and malformations, and associated syndromes. , 1996, Current problems in pediatrics.

[25]  S. Enshaieh,et al.  MULTIPLE GIANT DISSEMINATED PYOGENIC GRANULOMA IN THREE PATIENTS BURNED BY BOILING MILK , 1995, International journal of dermatology.

[26]  A. Metzker,et al.  Strawberry Hemangioma in Preterm Infants , 1986, Pediatric dermatology.

[27]  R. Kierland Diseases of the Skin: Clinical Dermatology , 1972 .

[28]  A. H. Jacobs Strawberry hemangiomas; the natural history of the untreated lesion. , 1957, California medicine.

[29]  K. Holmdahl,et al.  Cutaneous Hemangiomas in Premature and Mature Infants , 1955, Acta paediatrica.