Single-Cell Analysis of Proxy Reporter Allele-Marked Epithelial Cells Establishes Intestinal Stem Cell Hierarchy

[1]  F. D. de Sauvage,et al.  Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration. , 2014, Cell stem cell.

[2]  J. Epstein,et al.  Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells , 2013, Development.

[3]  R. Russell,et al.  Intestinal label-retaining cells are secretory precursors expressing Lgr5 , 2013, Nature.

[4]  A. Oudenaarden,et al.  Dll1+ secretory progenitor cells revert to stem cells upon crypt damage , 2012, Nature Cell Biology.

[5]  Alexander van Oudenaarden,et al.  The Lgr5 Intestinal Stem Cell Signature: Robust Expression of Proposed Quiescent ' Þ 4' Cell Markers , 2022 .

[6]  S. Ichinose,et al.  Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell , 2012, Nature Medicine.

[7]  Samuel E. Senyo,et al.  Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism , 2012, Nature.

[8]  M. Capecchi,et al.  The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations , 2011, Proceedings of the National Academy of Sciences.

[9]  J. Epstein,et al.  Interconversion Between Intestinal Stem Cell Populations in Distinct Niches , 2011, Science.

[10]  A. Oudenaarden,et al.  Single-molecule transcript counting of stem-cell markers in the mouse intestine , 2011, Nature Cell Biology.

[11]  O. Klein,et al.  A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable , 2011, Nature.

[12]  Hans Clevers,et al.  Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling , 2011, Nature.

[13]  Hans Clevers,et al.  The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. , 2011, Cell stem cell.

[14]  Hans Clevers,et al.  Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells , 2010, Cell.

[15]  Yong-ping Su,et al.  Normalizing genes for real-time polymerase chain reaction in epithelial and nonepithelial cells of mouse small intestine. , 2010, Analytical biochemistry.

[16]  Hans Clevers,et al.  Coexistence of Quiescent and Active Adult Stem Cells in Mammals , 2010, Science.

[17]  H. Clevers,et al.  Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche , 2009, Nature.

[18]  M. Capecchi,et al.  Bmi1 is expressed in vivo in intestinal stem cells , 2008, Nature Genetics.

[19]  H. Clevers,et al.  Identification of stem cells in small intestine and colon by marker gene Lgr5 , 2007, Nature.

[20]  S. Morrison,et al.  Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation , 2003, Nature.

[21]  Irving L. Weissman,et al.  Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells , 2003, Nature.

[22]  R. Schwartz,et al.  Hop Is an Unusual Homeobox Gene that Modulates Cardiac Development , 2002, Cell.

[23]  Christopher S Potten,et al.  Intestinal stem cells protect their genome by selective segregation of template DNA strands. , 2002, Journal of cell science.

[24]  油井 史郎.  Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell , 2011 .