Advanced analysis of nutraceuticals.

In this article, we present a review work on different nutraceuticals found in natural matrices together with the analytical techniques used to identify and/or quantify them with special emphasis in the period January 2005-May 2010. The work is distributed according to the different families of nutraceuticals (lipids, vitamins, proteins, glycosides, phenolic compounds, etc.) discussing the analytical techniques employed for their determination (separation, spectroscopic, hyphenated techniques, etc.). Information about the claimed health promoting effects of the different families of nutraceuticals is also provided together with data on the natural matrices in which they can be found (e.g., fruits, vegetables, plants, microalgae, cereals, milk, etc.).

[1]  Luigi Campanella,et al.  Determination of Lactoferrin and Immunoglobulin G in Animal Milks by New Immunosensors , 2009, Sensors.

[2]  A. Mazzanti,et al.  Content of flavonols in Italian bean (Phaseolus vulgaris L.) ecotypes , 2006 .

[3]  Seung-Cheol Lee,et al.  Extraction of nutraceutical compounds from licorice roots with subcritical water , 2008 .

[4]  M. Farag,et al.  Sulforaphane composition, cytotoxic and antioxidant activity of crucifer vegetables , 2010 .

[5]  Myeon-Hyeon Wang,et al.  HPLC analysis and antioxidant activity of Ulmus davidiana and some flavonoids , 2010 .

[6]  D. Yeung,et al.  A novel semisynthesized small molecule icaritin reduces incidence of steroid-associated osteonecrosis with inhibition of both thrombosis and lipid-deposition in a dose-dependent manner , 2008, Bone.

[7]  A. Fiorentino,et al.  Potential food additives from Carex distachya roots: identification and in vitro antioxidant properties. , 2008, Journal of agricultural and food chemistry.

[8]  Chia-Chuan Chang,et al.  Purification, structural elucidation, and anti-inflammatory effect of a water-soluble 1,6-branched 1,3-α-D-galactan from cultured mycelia of Poria cocos. , 2010 .

[9]  L. Estevinho,et al.  Chemical composition and biological properties of portuguese wild mushrooms: a comprehensive study. , 2008, Journal of agricultural and food chemistry.

[10]  Catalina S. Romano,et al.  Antioxidant and antimicrobial activities of rosemary extracts linked to their polyphenol composition , 2006, Free radical research.

[11]  G. Sivakumar,et al.  HPLC screening of anti-cancer sulforaphane from important European Brassica species , 2007 .

[12]  M. J. Vicente,et al.  Characterization by high-performance liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry of the lipid fraction of Spirulina platensis pressurized ethanol extract. , 2007, Rapid communications in mass spectrometry : RCM.

[13]  N. Seeram,et al.  Identification and bioactivities of resveratrol oligomers and flavonoids from Carex folliculata seeds. , 2009, Journal of agricultural and food chemistry.

[14]  G. Mazza,et al.  Triticale bran and straw: Potential new sources of phenolic acids, proanthocyanidins, and lignans , 2009 .

[15]  L. Mondello,et al.  Epoxycarotenoids esters analysis in intact orange juices using two-dimensional comprehensive liquid chromatography. , 2009, Journal of separation science.

[16]  E. Ibáñez,et al.  Screening for bioactive compounds from algae. , 2010, Journal of pharmaceutical and biomedical analysis.

[17]  T. Beta,et al.  Measurement of anthocyanins and other phytochemicals in purple wheat. , 2008, Food chemistry.

[18]  R. Upton,et al.  Quantitative analysis of flavonol glycosides in Ginkgo biloba: a comparison of two analytical methods. , 2006, Phytochemical analysis : PCA.

[19]  G. Shui,et al.  Residue from star fruit as valuable source for functional food ingredients and antioxidant nutraceuticals , 2006 .

[20]  P. He,et al.  Simultaneous determination of flavonoids and phenolic acids in Chinese herbal tea by beta-cyclodextrin based capillary zone electrophoresis , 2009 .

[21]  B. Carratù,et al.  Content of phytoestrogens in soy-based dietary supplements , 2009 .

[22]  K. Nakagawa,et al.  Quantitation of tocotrienol and tocopherol in various rice brans. , 2007, Journal of agricultural and food chemistry.

[23]  K. Mahadik,et al.  Simultaneous quantification of bergenin, catechin, and gallic acid from Bergenia ciliata and Bergenia ligulata by using thin-layer chromatography , 2008 .

[24]  R. Bennett,et al.  Evaluating the potential of chestnut (Castanea sativa Mill.) fruit pericarp and integument as a source of tocopherols, pigments and polyphenols , 2010 .

[25]  A. Marinas,et al.  Liquid chromatography/triple quadrupole tandem mass spectrometry with multiple reaction monitoring for optimal selection of transitions to evaluate nutraceuticals from olive-tree materials. , 2008, Rapid communications in mass spectrometry : RCM.

[26]  E. Ibáñez,et al.  Subcritical water extraction of nutraceuticals with antioxidant activity from oregano. Chemical and functional characterization. , 2006, Journal of pharmaceutical and biomedical analysis.

[27]  Christianne E. C. Rodrigues,et al.  Optimization of the rice bran oil deacidification process by liquid–liquid extraction , 2006 .

[28]  A. Sanahuja,et al.  Comparative study of tocopherol homologue content in four almond oil cultivars during two consecutive years , 2008 .

[29]  D. Arráez-Román,et al.  Tentative characterization of novel phenolic compounds in extra virgin olive oils by rapid-resolution liquid chromatography coupled with mass spectrometry. , 2009, Journal of agricultural and food chemistry.

[30]  Takuya Katsube,et al.  Identification of novel saponins from edible seeds of Japanese horse chestnut (Aesculus turbinata Blume) after treatment with wooden ashes and their nutraceutical activity. , 2006, Journal of pharmaceutical and biomedical analysis.

[31]  Jungmin Lee,et al.  Correlation of two anthocyanin quantification methods: HPLC and spectrophotometric methods , 2008 .

[32]  M. Grignon-Dubois,et al.  Chicoric acid from Syringodium filiforme. , 2010 .

[33]  N. Uccella,et al.  Demethyloleuropein and β-glucosidase activity in olive fruits , 2007 .

[34]  O. Yesil‐Celiktas,et al.  Supercritical CO2 extraction of glycosides from Stevia rebaudiana leaves: Identification and optimization , 2009 .

[35]  M. Garcia-Conesa,et al.  Nutraceuticals: facts and fiction. , 2007, Phytochemistry.

[36]  F. Tateo,et al.  Stabilization of cranberry anthocyanins in nutraceutical capsules , 2007, International journal of food sciences and nutrition.

[37]  Debasis Bagchi,et al.  Nutraceuticals and functional foods regulations in the United States and around the world. , 2006, Toxicology.

[38]  S. Zeisel Regulation of "Nutraceuticals" , 1999, Science.

[39]  W. Hurst Methods of analysis for functional foods and nutraceuticals , 2002 .

[40]  Se-kwon Kim,et al.  A novel angiotensin I converting enzyme inhibitory peptide from tuna frame protein hydrolysate and its antihypertensive effect in spontaneously hypertensive rats , 2010 .

[41]  Vermont P. Dia,et al.  The role of nutraceutical proteins and peptides in apoptosis, angiogenesis, and metastasis of cancer cells , 2010, Cancer and Metastasis Reviews.

[42]  N. Volpi Capillary electrophoresis determination of glucosamine in nutraceutical formulations after labeling with anthranilic acid and UV detection. , 2009, Journal of pharmaceutical and biomedical analysis.

[43]  V. Piironen,et al.  Tocopherol, tocotrienol and plant sterol contents of vegetable oils and industrial fats , 2008 .

[44]  T. Radjabian,et al.  "Research Note" ANALYSIS OF SILYMARIN COMPONENTS IN THE SEED EXTRACTS OF SOME MILK THISTLE ECOTYPES FROM IRAN BY HPLC * , 2008 .

[45]  I. Villegas,et al.  Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. , 2005, Molecular nutrition & food research.

[46]  R. Andriantsitohaina,et al.  Oral administration of polyphenolic compounds from cognac decreases ADP-induced platelet aggregation and reduces chronotropic effect of isoprenaline in rats. , 2008, Physiological research.

[47]  E. Ibáñez,et al.  Use of supercritical CO2 to obtain extracts with antimicrobial activity from Chaetoceros muelleri microalga. A correlation with their lipidic content , 2007 .

[48]  M. Sousa,et al.  Study and characterization of selected nutrients in wild mushrooms from Portugal by gas chromatography and high performance liquid chromatography , 2009 .

[49]  R. Luque,et al.  Physico-Chemical Characterisation of Lipids from Mytilus galloprovincialis (L.) and Rapana venosa and their Healing Properties on Skin Burns , 2008, Lipids.

[50]  J. Choo,et al.  Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans. , 2006, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[51]  Se-Kwon Kim,et al.  Purification and characterization of an antioxidant peptide obtained from tuna backbone protein by enzymatic hydrolysis , 2007 .

[52]  H. Yoon,et al.  Changes in nutraceutical lipid components of rice at different degrees of milling , 2006 .

[53]  C. Abdelly,et al.  Antioxidant and antimicrobial activities of the edible medicinal halophyte Tamarix gallica L. and related polyphenolic constituents. , 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[54]  T. Osawa,et al.  Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. , 2003, The Journal of nutrition.

[55]  T. Beta,et al.  Antioxidant activity of commercial wild rice and identification of flavonoid compounds in active fractions. , 2009, Journal of agricultural and food chemistry.

[56]  R. Helleur,et al.  Analysis of catechins and condensed tannins by thermally assisted hydrolysis/methylation-GC/MS and by a novel two step methylation. , 2009 .

[57]  T. McAlindon Nutraceuticals: do they work and when should we use them? , 2006, Best practice & research. Clinical rheumatology.

[58]  T. Beta,et al.  Antioxidant properties of commercial wild rice and analysis of soluble and insoluble phenolic acids , 2010 .

[59]  M. Affolter,et al.  OMICS-rooted studies of milk proteins, oligosaccharides and lipids. , 2009, Journal of proteomics.

[60]  I. López-Expósito,et al.  Application of mass spectrometry to the characterization and quantification of food-derived bioactive peptides. , 2008, Journal of AOAC International.

[61]  Chi-Tang Ho,et al.  Effects of processing on the nutraceutical profile of quinoa , 2007 .

[62]  F. Maccari,et al.  Quantitative and Qualitative Evaluation of Chondroitin Sulfate in Dietary Supplements , 2008 .

[63]  M. Caboni,et al.  Characterization of total, free and esterified phytosterols in tetraploid and hexaploid wheats. , 2009, Journal of agricultural and food chemistry.

[64]  L. Achour,et al.  Phenolic content and antioxidant activity of four date palm (Phoenix dactylifera L.) fruit varieties grown in Tunisia , 2009 .

[65]  Yong-Mu Kim,et al.  Licochalcone A: A lipase inhibitor from the roots of Glycyrrhiza uralensis , 2007 .

[66]  C. Shin,et al.  Isolation and characterization of a new compound from Prunus mume fruit that inhibits cancer cells. , 2006, Journal of agricultural and food chemistry.

[67]  T. Hayek,et al.  Phenolic antioxidants and antiatherogenic effects of Marula (Sclerocarrya birrea Subsp. caffra) fruit juice in healthy humans. , 2008, Journal of agricultural and food chemistry.

[68]  S. Chu,et al.  The tumor-growth inhibitory activity of flavanone and 2'-OH flavanone in vitro and in vivo through induction of cell cycle arrest and suppression of cyclins and CDKs. , 2007, Journal of biomedical science.

[69]  S. Lumyong,et al.  The presence and the content of Monacolins in Red Yeast rice prepared from Thai glutinous rice , 2008 .

[70]  E. Farnworth,et al.  A review of latest research findings on the health promotion properties of tea. , 2001, The Journal of nutritional biochemistry.

[71]  D. Sun-Waterhouse,et al.  Evaluation of the extraction efficiency for polyphenol extracts from by‐products of green kiwifruit juicing , 2009 .

[72]  Alejandro Cifuentes,et al.  Enrichment of vitamin E from Spirulina platensis microalga by SFE , 2008 .

[73]  Patrick Coppens,et al.  European regulations on nutraceuticals, dietary supplements and functional foods: a framework based on safety. , 2006, Toxicology.

[74]  S. Ercişli,et al.  Some physico-chemical characteristics of black mulberry (Morus nigra L.) genotypes from Northeast Anatolia region of Turkey , 2008 .

[75]  Luiz O. Oliveira,et al.  Protein, Oil, and Isoflavone Contents in Lipoxygenase- and Kunitz Trypsin Inhibitor-Deficient Soybean Seeds , 2007 .

[76]  Yun Wei,et al.  Separation of epigallocatechin and flavonoids from Hypericum perforatum L. by high-speed counter-current chromatography and preparative high-performance liquid chromatography. , 2009, Journal of chromatography. A.

[77]  Shiying Xu,et al.  Purification and characterization of type II collagen from chick sternal cartilage. , 2008, Food chemistry.

[78]  P. Variyar,et al.  Antioxidant activity of some phenolic constituents from green pepper (Piper nigrum L.) and fresh nutmeg mace (Myristica fragrans) , 2007 .

[79]  Andreas Schieber,et al.  Characterization of Canadian black currant (Ribes nigrum L.) seed oils and residues. , 2009, Journal of agricultural and food chemistry.

[80]  L. Mondello,et al.  Comprehensive normal-phase x reversed-phase liquid chromatography coupled to photodiode array and mass spectrometry detection for the analysis of free carotenoids and carotenoid esters from mandarin. , 2008, Journal of chromatography. A.

[81]  Devanand L. Luthria,et al.  PHENOLIC ACIDS PROFILING AND ANTIOXIDANT POTENTIAL OF MULBERRY (MORUS LAEVIGATA W., MORUS NIGRA L., MORUS ALBA L.) LEAVES AND FRUITS GROWN IN PAKISTAN , 2010 .

[82]  Sun-Ju Kim,et al.  Effect of Natural Light Periods on Rutin, Free Amino Acid and Vitamin C Contents in the Sprouts of Common (Fagopyrum esculentum Moench) and Tartary (F. tataricum Gaertn.) Buckwheats , 2006 .

[83]  M. Iriti,et al.  Melatonin content in grape: myth or panacea? , 2006 .

[84]  M. D. Luque de Castro,et al.  Determination of phenolic compounds in grape skin by capillary electrophoresis with simultaneous dual fluorescence and diode array absorption detection after dynamic superheated liquid leaching. , 2007, Journal of chromatography. A.

[85]  V. Tešević,et al.  Influence of thermal treatment on phenolic compounds and antioxidant properties of oak acorns from Serbia , 2007 .

[86]  Matteo D'Amore,et al.  Phenolic constituents levels in cv. Agria potato under microwave processing , 2008 .

[87]  Shih-Chuan Liu,et al.  Composition of flavonoids and phenolic acids in Glycin tomentella Hayata cultivated in various soils , 2010 .

[88]  G. Haegeman,et al.  Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds. , 2009, Journal of natural products.

[89]  C. Tringali,et al.  Polyphenol-enriched fractions from Sicilian grape pomace: HPLC-DAD analysis and antioxidant activity. , 2008, Bioresource technology.

[90]  C. Schacky The role of omega-3 fatty acids in cardiovascular disease , 2003 .

[91]  F. Destaillats,et al.  Triacylglycerols of Apiaceae seed oils: Composition and regiodistribution of fatty acids , 2009 .

[92]  B. Gallo,et al.  A general analytical strategy for the characterization of phenolic compounds in fruit juices by high-performance liquid chromatography with diode array detection coupled to electrospray ionization and triple quadrupole mass spectrometry. , 2009, Journal of chromatography. A.

[93]  R. Karjalainen,et al.  Red clover (Trifolium pratense L.) isoflavones: determination of concentrations by plant stage, flower colour, plant part and cultivar , 2008 .

[94]  Chibuike C. Udenigwe,et al.  Multifunctional peptides from egg white lysozyme , 2010 .

[95]  E. Ibáñez,et al.  A systematic study on the interactions between carnosic acid and ethylpyrrolidine methacrylate–methyl methacrylate copolymer in supercritical media , 2007 .

[96]  P. Manchand,et al.  β,β-Carotene , 1996 .

[97]  Chang Yong Lee,et al.  Optimization of phenolics and dietary fibre extraction from date seeds. , 2008, Food chemistry.

[98]  B. Lokesh,et al.  Hypolipidemic effect of oils with balanced amounts of fatty acids obtained by blending and interesterification of coconut oil with rice bran oil or sesame oil. , 2007, Journal of agricultural and food chemistry.

[99]  E. Ibáñez,et al.  Optimization of the extraction of antioxidants from Dunaliella salina microalga by pressurized liquids. , 2006, Journal of agricultural and food chemistry.

[100]  E. Ibáñez,et al.  Pressurized fluid extraction of bioactive compounds from Phormidium species. , 2008, Journal of agricultural and food chemistry.

[101]  R. Pedreschi,et al.  High-performance liquid chromatography with photodiode array detection (HPLC-DAD)/HPLC-mass spectrometry (MS) profiling of anthocyanins from Andean Mashua Tubers (Tropaeolum tuberosum Ruíz and Pavón) and their contribution to the overall antioxidant activity. , 2006, Journal of agricultural and food chemistry.

[102]  S. N. Pramod,et al.  Identity of the immunomodulatory proteins from garlic (Allium sativum) with the major garlic lectins or agglutinins. , 2010, International immunopharmacology.

[103]  Paula Baptista,et al.  Wild and commercial mushrooms as source of nutrients and nutraceuticals. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[104]  R. Peralta,et al.  Antioxidant activity and total phenolic content of Agaricus brasiliensis (Agaricus blazei Murril) in two stages of maturity , 2009 .

[105]  R. Przybylski,et al.  Lipid Components of North American Wild Rice (Zizania palustris) , 2009 .

[106]  Baojun Xu,et al.  Total phenolics, phenolic acids, isoflavones, and anthocyanins and antioxidant properties of yellow and black soybeans as affected by thermal processing. , 2008, Journal of agricultural and food chemistry.

[107]  S. Furlanetto,et al.  Multivariate optimisation and validation of a capillary electrophoresis method for the analysis of resveratrol in a nutraceutical. , 2008, Talanta.

[108]  G. Mazza,et al.  Optimization of solid-liquid extraction of resveratrol and other phenolic compounds from milled grape canes (Vitis vinifera). , 2008, Journal of agricultural and food chemistry.

[109]  F. Anwar,et al.  Fatty Acid, Tocopherol and Sterol Compositions of Canadian Prairie Fruit Seed Lipids , 2008 .

[110]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[111]  Usha Thiyam,et al.  De-oiled rapeseed and a protein isolate: characterization of sinapic acid derivatives by HPLC–DAD and LC–MS , 2009 .

[112]  R. Bottini,et al.  Phenolic composition in grape (Vitis vinifera L. cv. Malbec) ripened with different solar UV-B radiation levels by capillary zone electrophoresis. , 2008, Journal of agricultural and food chemistry.

[113]  Noritada Kaji,et al.  Quantitative determination of amino acids in functional foods by microchip electrophoresis. , 2008, Journal of separation science.

[114]  M. C. Lanari,et al.  Phenolic acids composition and antioxidant activity of canola extracts in cooked beef, chicken and pork , 2010 .

[115]  Rekha S. Singhal,et al.  Supercritical CO2 extraction of γ-linolenic acid (GLA) from Spirulina platensis ARM 740 using response surface methodology , 2008 .

[116]  G. D’ascenzo,et al.  Simultaneous determination of water-soluble vitamins in selected food matrices by liquid chromatography/electrospray ionization tandem mass spectrometry. , 2008, Rapid communications in mass spectrometry : RCM.

[117]  Karamatollah Rezaei,et al.  Comparison of microwave-assisted hydrodistillation withthe traditional hydrodistillation method in the extractionof essential oils from Thymus vulgaris L. , 2008, Food chemistry.

[118]  G. Reglero,et al.  Recovery of squalene from vegetable oil sources using countercurrent supercritical carbon dioxide extraction , 2007 .

[119]  Guonan Chen,et al.  An improved facile method for extraction and determination of steroidal saponins in Tribulus terrestris by focused microwave-assisted extraction coupled with GC-MS. , 2009, Journal of separation science.

[120]  V. Navaratnam,et al.  Chemical constituents and in vitro anticancer activity of Typhonium flagelliforme (Araceae). , 2010, Journal of ethnopharmacology.

[121]  P. Goetz,et al.  Ribes nigrum L. , 2008, Phytothérapie.

[122]  L. Abrankó,et al.  Three-step HPLC–ESI-MS/MS procedure for screening and identifying non-target flavonoid derivatives , 2010 .

[123]  V. Stocchi,et al.  Biochemical characterisation and antioxidant activity of mycelium of Ganoderma lucidum from Central Italy , 2009 .

[124]  M. Netzel,et al.  Sources of antioxidant activity in Australian native fruits. Identification and quantification of anthocyanins. , 2006, Journal of agricultural and food chemistry.

[125]  Rozenn Ravallec,et al.  Purification and identification of novel antioxidant peptides from enzymatic hydrolysates of sardinelle (Sardinella aurita) by-products proteins. , 2010 .

[126]  Ajay P. Singh,et al.  Isolation of Specific Cranberry Flavonoids for Biological Activity Assessment. , 2009, Food chemistry.

[127]  Stéphanie Jung,et al.  Isoflavone profiles of soymilk as affected by high-pressure treatments of soymilk and soybeans , 2008 .

[128]  G. Reglero,et al.  Supercritical fluid extraction of minor lipids from pretreated sunflower oil deodorizer distillates , 2006 .

[129]  L. Srinivas,et al.  Purification and characterization of ∼35 kDa antioxidant protein from curry leaves (Murraya koenigii L.) , 2008 .

[130]  Bambang Veriansyah,et al.  Extraction of bioactive components from Centella asiatica using subcritical water , 2009 .

[131]  C. Haller Nutraceuticals: Has There Been Any Progress? , 2010, Clinical pharmacology and therapeutics.

[132]  S. Deshmukh,et al.  Nutraceuticals , 2021, Treating Endocrine and Metabolic Disorders With Herbal Medicines.

[133]  G. Peluso,et al.  Polyunsaturated Fatty Acids: Biochemical, Nutritional and Epigenetic Properties , 2004, Journal of the American College of Nutrition.

[134]  S. Ercişli,et al.  Chemical composition of blood orange varieties from Turkey: a comparative study. , 2009 .

[135]  Yeong Shik Kim,et al.  Evaluation of chondroitin sulfate in shark cartilage powder as a dietary supplement: Raw materials and finished products , 2007 .

[136]  K. Engel,et al.  Content of gamma-oryzanol and composition of steryl ferulates in brown rice (Oryza sativa L.) of European origin. , 2006, Journal of agricultural and food chemistry.

[137]  C. Fredes Antioxidants in Chilean native berries. , 2009 .

[138]  L. Yu,et al.  Effects of conjugated linoleic acid (CLA) isomers on oxygen diffusion-concentration products in liposomes and phospholipid solutions. , 2006, Journal of agricultural and food chemistry.

[139]  D. Hernández-López,et al.  Physicochemical, nutritional and functional characteristics of two underutilised fruit cactus species (Myrtillocactus) produced in central Mexico , 2010 .

[140]  W. Prinyawiwatkul,et al.  FA composition of the oil extracted from farmed atlantic salmon (Salmo salar L.) viscera , 2006 .

[141]  A. Alegría,et al.  Determination of sialic acid and gangliosides in biological samples and dairy products: a review. , 2010, Journal of pharmaceutical and biomedical analysis.

[142]  Trust Beta,et al.  An evaluation of the antioxidant properties and aroma quality of infant cereals , 2010 .

[143]  J. Pejin,et al.  Investigation of Phenolic Acids Content and Antioxidant Activity in Malt Production , 2009 .

[144]  Sylvia Adjoa Mitchell,et al.  Extraction, processing, and storage effects on curcuminoids and oleoresin yields from Curcuma longa L. grown in Jamaica. , 2008, Journal of agricultural and food chemistry.

[145]  L. F. D'Antuono,et al.  Glucosinolates in Diplotaxis and Eruca leaves: diversity, taxonomic relations and applied aspects. , 2008, Phytochemistry.

[146]  G. Mazza,et al.  Mass transfer during pressurized low polarity water extraction of lignans from flaxseed meal , 2008 .

[147]  Mónica González,et al.  Antioxidant activity in banana peel extracts: Testing extraction conditions and related bioactive compounds , 2010 .

[148]  Tabiwang N. Arrey,et al.  Structural characterization of 132-hydroxy-(132-S)-phaeophytin-a from leaves and stems of Amaranthus tricolor isolated by high-speed countercurrent chromatography , 2007 .

[149]  G. Mazza,et al.  Extraction of saponins and cyclopeptides from cow cockle seed with pressurized low polarity water , 2008 .

[150]  Y. Man,et al.  Physicochemical properties and bioactive compounds of selected seed oils , 2009 .

[151]  A. Piga,et al.  Polyphenol composition of peel and pulp of two Italian fresh fig fruits cultivars (Ficus carica L.) , 2008 .

[152]  L. Krenn,et al.  An efficient HPLC method for the quantification of isoflavones in soy extracts and soy dietary supplements in routine quality control. , 2006, Die Pharmazie.

[153]  E. Ibáñez,et al.  Innovative natural functional ingredients from microalgae. , 2009, Journal of agricultural and food chemistry.

[154]  G. Giovanelli,et al.  Antioxidant composition of tomato products typically consumed in Italy. , 2009 .

[155]  Baoru Yang,et al.  Characterization of phenolic compounds in Chinese hawthorn (Crataegus pinnatifida Bge. var. major) fruit by high performance liquid chromatography–electrospray ionization mass spectrometry , 2010 .

[156]  Tonino Caruso,et al.  Characterization of high purity lycopene from tomato wastes using a new pressurized extraction approach. , 2008, Journal of agricultural and food chemistry.

[157]  S. Siriamornpun,et al.  Antioxidant capacities and phenolic compounds of the husk, bran and endosperm of Thai rice. , 2010 .

[158]  J. Lupton,et al.  Suppression of colon carcinogenesis by bioactive compounds in grapefruit. , 2006, Carcinogenesis.

[159]  G. Morlock,et al.  Simultaneous determination of riboflavin, pyridoxine, nicotinamide, caffeine and taurine in energy drinks by planar chromatography-multiple detection with confirmation by electrospray ionization mass spectrometry. , 2006, Journal of chromatography. A.

[160]  L. Beaulieu,et al.  Proteolytic processing of herring (Clupea harengus): biochemical and nutritional characterisation of hydrolysates , 2009 .

[161]  R. Aluko,et al.  Functional properties of yellow field pea (Pisum sativum L.) seed flours and the in vitro bioactive properties of their polyphenols. , 2010 .

[162]  Chi-Tang Ho,et al.  Hydroxylated polymethoxyflavones and methylated flavonoids in sweet orange (Citrus sinensis) peel. , 2006, Journal of agricultural and food chemistry.

[163]  D. Liebler,et al.  Fatty Acid , 2020, Definitions.

[164]  E. Perri,et al.  Gas chromatography screening of bioactive phytosterols from mono-cultivar olive oils , 2006 .

[165]  B. Peterson,et al.  Enrichment of channel catfish (Ictalurus punctatus) fillets with conjugated linoleic acid and omega-3 fatty acids by dietary manipulation , 2006 .

[166]  J. Hansen,et al.  No significant effect on bone mineral density by high doses of vitamin D3 given to overweight subjects for one year , 2010, Nutrition journal.

[167]  S. Czaplicki,et al.  Chemical composition of Pinus sibirica nut oils , 2009 .

[168]  R. Agrawal,et al.  Volatile Compounds of Therapeutic Importance Produced by Leuconostoc paramesenteroides, a Native Laboratory Isolate , 2007 .

[169]  G. F. Barbero,et al.  Ultrasound-assisted extraction of capsaicinoids from peppers. , 2008, Talanta.

[170]  Ana Maria Carvalho,et al.  Strawberry-tree, blackthorn and rose fruits: detailed characterisation in nutrients and phytochemicals with antioxidant properties. , 2010 .

[171]  A. Mobasheri,et al.  Nutraceutical Therapies for Degenerative Joint Diseases: A Critical Review , 2005, Critical reviews in food science and nutrition.

[172]  M. Ramadan,et al.  Characterisation of fatty acids and bioactive compounds of kachnar (Bauhinia purpurea L.) seed oil , 2006 .

[173]  A. Sundaresan,et al.  An ecofriendly approach to process rice bran for high quality rice bran oil using supercritical carbon dioxide for nutraceutical applications. , 2008, Bioresource technology.

[174]  M. de Castro,et al.  Temporal metabolomic analysis of o-glucoside phenolic compounds and their aglycone forms in olive tree and derived materials. , 2009, Phytochemical analysis : PCA.

[175]  A. Siger,et al.  THE CONTENT AND ANTIOXIDANT ACTIVITY OF PHENOLIC COMPOUNDS IN COLD‐PRESSED PLANT OILS , 2008 .

[176]  M. Sójka,et al.  Composition of industrial seedless black currant pomace , 2009 .

[177]  Sahari,et al.  Determination of Main Tea Seed Oil Antioxidants and their Effects on Common Kilka Oil , 2009 .

[178]  I. Mocchetti Exogenous gangliosides, neuronal plasticity and repair, and the neurotrophins , 2005, Cellular and Molecular Life Sciences CMLS.

[179]  M. Koffas,et al.  High‐yield anthocyanin biosynthesis in engineered Escherichia coli , 2008, Biotechnology and bioengineering.

[180]  B. Nobre,et al.  Supercritical carbon dioxide extraction of astaxanthin and other carotenoids from the microalga Haematococcus pluvialis , 2006 .

[181]  S. Dall’Acqua,et al.  Steroidal glycosides from Hoodia gordonii , 2007, Steroids.

[182]  K. Stark,et al.  Direct Determinations of the Fatty Acid Composition of Daily Dietary Intakes Incorporating Nutraceuticals and Functional Food Strategies to Increase n-3 Highly Unsaturated Fatty Acids , 2008, Journal of the American College of Nutrition.

[183]  G. Nader,et al.  A review of fatty acid profiles and antioxidant content in grass-fed and grain-fed beef , 2010, Nutrition journal.

[184]  J. Manthey Fourier transform infrared spectroscopic analysis of the polymethoxylated flavone content of orange oil residues. , 2006, Journal of agricultural and food chemistry.

[185]  P. Winterhalter,et al.  Quantitative Determination of Isoflavones in Soy Based Nutritional Supplements by High-Performance Liquid Chromatography , 2008, Journal für Verbraucherschutz und Lebensmittelsicherheit.

[186]  D. Kitts,et al.  Mycosporine-like amino acid composition of the edible red alga, Palmaria palmata (dulse) harvested from the west and east coasts of Grand Manan Island, New Brunswick , 2009 .

[187]  A. Bendini,et al.  CAPILLARY GAS CHROMATOGRAPHY ANALYSIS OF LIPID COMPOSITION AND EVALUATION OF PHENOLIC COMPOUNDS BY MICELLAR ELECTROKINETIC CHROMATOGRAPHY IN ITALIAN WALNUT (JUGLANS REGIA L.): IRRIGATION AND FERTILIZATION INFLUENCE , 2009 .

[188]  A. Humeny,et al.  Analysis of the peptide profile of milk and its changes during thermal treatment and storage. , 2008, Journal of agricultural and food chemistry.

[189]  I. Koca,et al.  Physico-chemical and antioxidant properties of cornelian cherry fruits (Cornus mas L.) grown in Turkey , 2008 .

[190]  J. Sherma,et al.  Analysis of lycopene in nutritional supplements by silica gel high-performance thin-layer chromatography with visible-mode densitometry , 2008 .

[191]  Chi-Tang Ho,et al.  Food factors in health promotion and disease prevention , 2003 .

[192]  Gordon C. Tucker Morus alba L. , 2001 .

[193]  H. Godoy,et al.  Vitamins B1 and B2 contents in cultivated mushrooms , 2008 .

[194]  D. Corradini,et al.  Identification and quantification of phenolic compounds in grapes by HPLC-PDA-ESI-MS on a semimicro separation scale. , 2008, Journal of agricultural and food chemistry.

[195]  A. Kamal-Eldin,et al.  Phenolic compounds in Rosaceae fruits from Ecuador. , 2009, Journal of agricultural and food chemistry.

[196]  B. Marzouk,et al.  Glycerolipid and fatty acid distribution in pericarp, seed and whole fruit oils of Myrtus communis var. italica , 2010 .

[197]  H. Bartsch,et al.  Characterization of alkyl phenols in cashew (Anacardium occidentale) products and assay of their antioxidant capacity. , 2006, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[198]  E. Ibáñez,et al.  Profiling of different bioactive compounds in functional drinks by high-performance liquid chromatography. , 2008, Journal of chromatography. A.

[199]  K. Miyashita,et al.  EVALUATION OF RECOVERABLE FUNCTIONAL LIPID COMPONENTS OF SEVERAL BROWN SEAWEEDS (PHAEOPHYTA) FROM JAPAN WITH SPECIAL REFERENCE TO FUCOXANTHIN AND FUCOSTEROL CONTENTS 1 , 2009, Journal of phycology.

[200]  L. Velasco,et al.  Novel seed oil types of Ethiopian mustard with high levels of polyunsaturated fatty acids , 2008 .

[201]  B. Gallo,et al.  New features on the fragmentation and differentiation of C-glycosidic flavone isomers by positive electrospray ionization and triple quadrupole mass spectrometry. , 2008, Rapid communications in mass spectrometry : RCM.

[202]  Ana Maria Carvalho,et al.  Aromatic plants as a source of important phytochemicals: Vitamins, sugars and fatty acids in Cistus ladanifer, Cupressus lusitanica and Eucalyptus gunnii leaves. , 2009 .

[203]  R. Karjalainen,et al.  High-performance liquid chromatography analysis of black currant (Ribes nigrum L.) fruit phenolics grown either conventionally or organically. , 2006, Journal of agricultural and food chemistry.

[204]  R. Lobinski,et al.  ICP-MS-assisted nanoHPLC-electrospray Q/time-of-flight MS/MS selenopeptide mapping in Brazil nuts , 2007 .

[205]  S. Czaplicki,et al.  Phenolic acid profiles of mangosteen fruits (Garcinia mangostana) , 2009 .

[206]  S. Schwartz,et al.  Determination of anthocyanins, total phenolic content, and antioxidant activity in Andes Berry (Rubus glaucus Benth). , 2009, Journal of food science.

[207]  S. Abbasi,et al.  Anthocyanins characterization of 15 Iranian pomegranate (Punica granatum L.) varieties and their variation after cold storage and pasteurization , 2008 .

[208]  J. German,et al.  Phytochemicals: nutraceuticals and human health , 2000 .

[209]  G. Vilahur,et al.  Nutraceuticals and atherosclerosis: human trials. , 2010, Cardiovascular therapeutics.

[210]  B. Carratù,et al.  Determination of alpha-amylase inhibitor activity of phaseolamin from kidney bean (Phaseolus vulgaris) in dietary supplements by HPAEC-PAD. , 2008, Analytica chimica acta.

[211]  S. Mir,et al.  Chemical composition of fixed oil of Olea europaea drupes from Iraq. , 2009 .

[212]  Isabel Odriozola-Serrano,et al.  Antioxidant content of fresh-cut pears stored in high-O2 active packages compared with conventional low-o2 active and passive modified atmosphere packaging. , 2008, Journal of agricultural and food chemistry.

[213]  I. Orhan,et al.  Discovery of drug candidates from some Turkish plants and conservation of biodiversity , 2005 .

[214]  K. Srinivasan Role of Spices Beyond Food Flavoring: Nutraceuticals with Multiple Health Effects , 2005 .

[215]  M. Sousa,et al.  Optimization of analytical procedures for GC–MS determination of phytosterols and phytostanols in enriched milk and yoghurt , 2007 .

[216]  F. Han,et al.  HPLC-DAD-ESI-MS/MS analysis and antioxidant activities of nonanthocyanin phenolics in mulberry (Morus alba L.). , 2008, Journal of food science.

[217]  R. Veberič,et al.  Phenolic characterization of some hazelnut cultivars from different European germplasm collections , 2009 .

[218]  Young Soon Kim,et al.  Ectopic expression of serotonin N-hydroxycinnamoyltransferase and differential production of phenylpropanoid amides in transgenic tomato tissues , 2009 .

[219]  P. Sungpuag,et al.  Beta-carotene, lycopene, and alpha-tocopherol contents of selected Thai fruits , 2009 .

[220]  Hui-ming Zhou,et al.  RETRACTED: Biologically active components and nutraceuticals in sesame and related products: a review and prospect , 2007 .

[221]  M. Bronze,et al.  Phenolic Content and Antioxidant Activity of Moscatel Dessert Wines from the Setúbal Region in Portugal , 2009 .

[222]  P. Cioni,et al.  In vitro activity of the essential oils of Origanum vulgare, Satureja montana and their main constituents in peroxynitrite-induced oxidative processes , 2007 .

[223]  S. Fanali,et al.  Quantitation of chiral amino acids from microalgae by MEKC and LIF detection , 2007, Electrophoresis.

[224]  N. Yoon,et al.  Phlorotannins from Ishige okamurae and their acetyl- and butyrylcholinesterase inhibitory effects , 2009 .

[225]  Y. Ju,et al.  Purification and identification of rice bran oil fatty acid steryl and wax esters , 2006 .

[226]  Hosahalli S. Ramaswamy,et al.  Pumpkin (Cucurbita maxima) seed oil extraction using supercritical carbon dioxide and physicochemical properties of the oil , 2009 .

[227]  A. Theocharis,et al.  Capillary electrophoresis for the quality control of chondroitin sulfates in raw materials and formulations. , 2008, Analytical biochemistry.

[228]  B. Bergenståhl,et al.  Total antioxidant capacity and content of flavonoids and other phenolic compounds in canihua (Chenopodium pallidicaule): an Andean pseudocereal. , 2008, Molecular nutrition & food research.

[229]  E. Ibáñez,et al.  Beta-carotene isomer composition of sub- and supercritical carbon dioxide extracts. Antioxidant activity measurement. , 2007, Journal of agricultural and food chemistry.

[230]  N. Bandarra,et al.  The effect of low temperature on fatty acid composition and tocopherols of the red microalga, Porphyridium cruentum , 2007, Journal of Applied Phycology.

[231]  Martina Medvidović‐Kosanović,et al.  Anthocyanin content and antioxidant activity of various red fruit juices , 2007 .

[232]  P. Ferranti,et al.  Characterisation and cytomodulatory properties of peptides from Mozzarella di Bufala Campana cheese whey , 2009, Journal of peptide science : an official publication of the European Peptide Society.

[233]  A. Sinha,et al.  RP-HPTLC densitometric determination and validation of vanillin and related phenolic compounds in accelerated solvent extract of Vanilla planifolia*. , 2007, Journal of separation science.

[234]  E. Ibáñez,et al.  Supercritical technology as an alternative to fractionate prebiotic galactooligosaccharides , 2009 .

[235]  M. Sovák,et al.  Resveratrol and its glycon piceid are stable polyphenols. , 2006, Journal of medicinal food.

[236]  B. Nobre,et al.  Functional food oil coloured by pigments extracted from microalgae with supercritical CO2 , 2007 .