Comment: 2004's fastest organic and biomolecular chemistry!

In January 2003, the Royal Society of Chemistry launched Organic & Biomolecular Chemistry (OBC)--a journal promising to provide high quality research from all aspects of synthetic, physical and biomolecular organic chemistry. The journal was set to build upon the foundations laid down by its predecessor publications (J. Chem. Soc., Perkin Trans. 1 and J. Chem. Soc., Perkin Trans. 2) as well as complement the subject coverage already published in prestigious general chemistry journals such as Chemical Communications and Chemical Society Reviews. Nearly two years on, just how is the programme developing and what can the community expect to see from the Royal Society of Chemistry (RSC)?

[1]  F. Diederich,et al.  A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions. , 2004, Organic & biomolecular chemistry.

[2]  R. Akiyama,et al.  Renaissance of immobilized catalysts. New types of polymer-supported catalysts, 'microencapsulated catalysts', which enable environmentally benign and powerful high-throughput organic synthesis. , 2003, Chemical communications.

[3]  R. Pye,et al.  The tethered aminohydroxylation (TA) reaction. , 2003, Organic & biomolecular chemistry.

[4]  Tamsyn Montagnon,et al.  Tandem reactions, cascade sequences, and biomimetic strategies in total synthesis. , 2003, Chemical communications.

[5]  M. Joullié,et al.  Cyclopeptide alkaloids: chemistry and biology. , 2004, Chemical communications.

[6]  C. Parish,et al.  Convergent synthesis and preliminary biological evaluations of the stilbenolignan (+/-)-aiphanol and various congeners. , 2003, Organic & biomolecular chemistry.

[7]  S. Gibson,et al.  Chiral base-mediated benzylic functionalisation of tricarbonylchromium(0) complexes of benzylamine derivatives. , 2003, Organic & biomolecular chemistry.

[8]  H. Zipse,et al.  1,2-Chlorine atom migration in 3-chloro-2-butyl radicals: a computational study. , 2003, Organic & biomolecular chemistry.

[9]  C. Bolm,et al.  Synthesis of novel chiral phosphinocyrhetrenyloxazoline ligands and their application in asymmetric catalysis. , 2003, Organic & biomolecular chemistry.

[10]  G. Gokel.  The aromatic sidechains of amino acids as neutral donor groups for alkali metal cations. , 2003, Chemical communications.

[11]  James J La Clair,et al.  Molecular screening on a compact disc. , 2003, Organic & biomolecular chemistry.

[12]  J. Wengel,et al.  Nucleic acid nanotechnology-towards Angstrom-scale engineering. , 2004, Organic & biomolecular chemistry.

[13]  Junlin He,et al.  Oligonucleotides incorporating 8-aza-7-deazapurines: synthesis and base pairing of nucleosides with nitrogen-8 as a glycosylation position. , 2003, Organic & biomolecular chemistry.

[14]  P. Bäuerle,et al.  Combinatorial organic materials research (COMR): design, synthesis and screening of a 225-membered materials library of liquid crystalline fluorinated p-quaterphenyls. , 2003, Organic & biomolecular chemistry.

[15]  Jean Chmielewski,et al.  Challenges in the design of self replicating peptides. , 2003, Organic & biomolecular chemistry.

[16]  Chi‐Huey Wong,et al.  HIV-1 protease: mechanism and drug discovery. , 2003, Organic & biomolecular chemistry.

[17]  W. Zhuang,et al.  Formation of optically active chromanes by catalytic asymmetric tandem oxa-Michael addition-Friedel-Crafts alkylation reactions. , 2003, Organic & biomolecular chemistry.

[18]  V. Snieckus.  Chemistry of Heterocyclic Compounds, Oxazoles: Synthesis, Reactions, and Spectroscopy, Part A , 2004 .

[19]  Nicholas J Turner,et al.  Directed evolution of enzymes: new biocatalysts for asymmetric synthesis. , 2003, Organic & biomolecular chemistry.

[20]  Dennis G. Gillingham,et al.  Ru complexes bearing bidentate carbenes: from innocent curiosity to uniquely effective catalysts for olefin metathesis. , 2004, Organic & biomolecular chemistry.

[21]  S. Denmark,et al.  Catalytic enantioselective allylation with chiral Lewis bases. , 2003, Chemical communications.

[22]  S. Fukuzumi.  New perspective of electron transfer chemistry. , 2003, Organic & biomolecular chemistry.

[23]  J. Rebek,et al.  The ins and outs of molecular encapsulation. , 2004, Organic & biomolecular chemistry.

[24]  F. Diederich,et al.  Acetylenic scaffolding on solid support: poly(triacetylene)-derived oligomers by Sonogashira and Cadiot-Chodkiewicz-type cross-coupling reactions. , 2003, Organic & biomolecular chemistry.

[25]  S. Ley,et al.  Synthesis of (-)-gloeosporone, a fungal autoinhibitor of spore germination using a pi-allyltricarbonyliron lactone complex as a templating architecture for 1,7-diol construction. , 2003, Organic & biomolecular chemistry.

[26]  M. Burkart.  Metabolic engineering--a genetic toolbox for small molecule organic synthesis. , 2003, Organic & biomolecular chemistry.

[27]  M. Nahmany,et al.  Chemoselectivity in reactions of esterification. , 2004, Organic & biomolecular chemistry.

[28]  H. Imahori,et al.  Porphyrin-fullerene linked systems as artificial photosynthetic mimics. , 2004, Organic & biomolecular chemistry.

[29]  S. Balasubramanian,et al.  Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform. , 2004, Organic & biomolecular chemistry.

[30]  A. Hobson,et al.  Highly diastereoselective 1,3-dipolar cycloaddition reactions of trans-2-methylene-1,3-dithiolane 1,3-dioxide with 3-oxidopyridinium and 3-oxidopyrylium betaines: a route to the tropane skeleton. , 2003, Organic & biomolecular chemistry.

[31]  T. Carell,et al.  Electrontransfer through DNA and metal-containing DNA. , 2003, Organic & biomolecular chemistry.

[32]  K. Maruoka,et al.  Meerwein-Ponndorf-Verley alkynylation of aldehydes: essential modification of aluminium alkoxides for rate acceleration and asymmetric synthesis. , 2004, Organic & biomolecular chemistry.

[33]  A. Plowright,et al.  Total synthesis of (+)-phorboxazole A, a potent cytostatic agent from the sponge Phorbas sp. , 2003, Organic & biomolecular chemistry.

[34]  P. Wipf,et al.  Synthesis and biological evaluation of caulibugulones A-E. , 2004, Organic & biomolecular chemistry.

[35]  M. Sigman,et al.  The renaissance of palladium(II)-catalyzed oxidation chemistry. , 2004, Organic & biomolecular chemistry.

[36]  Tom W Muir,et al.  "The splice is right": how protein splicing is opening new doors in protein science. , 2003, Chemical communications.

[37]  S. Lincoln,et al.  Diazacoronand linked beta-cyclodextrin dimer complexes of Brilliant Yellow tetraanion and their sodium(I) analogues. , 2003, Organic & biomolecular chemistry.

[38]  R. Noyori,et al.  Green oxidation with aqueous hydrogen peroxide. , 2003, Chemical communications.

[39]  S. Silverman,et al.  Deoxyribozymes: DNA catalysts for bioorganic chemistry. , 2004, Organic & biomolecular chemistry.

[40]  W. A. van der Donk,et al.  Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids. , 2003, Chemical communications.

[41]  Rahul M Kohli,et al.  Enzymology of acyl chain macrocyclization in natural product biosynthesis. , 2003, Chemical communications.

[42]  A. Nelson.  The development of strategies and methods for the synthesis of biologically active compounds , 2004 .

[43]  V. Lynch,et al.  Water soluble sapphyrins: potential fluorescent phosphate anion sensors. , 2003, Organic & biomolecular chemistry.

[44]  S. Weiner,et al.  An organic hydrogel as a matrix for the growth of calcite crystals. , 2004, Organic & biomolecular chemistry.

[45]  S. Shinkai,et al.  Proton-sensitive fluorescent organogels. , 2003, Organic & biomolecular chemistry.

[46]  F. Opperdoes,et al.  Natural products active against African trypanosomes: a step towards new drugs. , 2004, Natural product reports.

[47]  I. Fleming,et al.  The Ireland-Claisen rearrangement as a probe for the diastereoselectivity of nucleophilic attack on a double bond adjacent to a stereogenic centre carrying a silyl group. , 2003, Organic & biomolecular chemistry.

[48]  B. Feringa,et al.  Exploring the boundaries of a light-driven molecular motor design: new sterically overcrowded alkenes with preferred direction of rotation. , 2004, Organic & biomolecular chemistry.

[49]  Jeffrey S. Moore,et al.  Nucleation-elongation: a mechanism for cooperative supramolecular polymerization. , 2003, Organic & biomolecular chemistry.

[50]  S. Otto,et al.  Hydrophobic interactions and chemical reactivity. , 2003, Organic & biomolecular chemistry.

[51]  K. Baldridge,et al.  Through-space interactions between face-to-face, center-to-edge oriented arenes: importance of polar-pi effects. , 2003, Organic & biomolecular chemistry.

[52]  A. Mapp.  Regulating transcription: a chemical perspective. , 2003, Organic & biomolecular chemistry.

[53]  Dudley H. Williams,et al.  How can enzymes be so efficient? , 2003, Chemical communications.

[54]  S. Gibson,et al.  [2.2]Paracyclophane derivatives in asymmetric catalysis. , 2003, Organic & biomolecular chemistry.

[55]  C. Abell,et al.  Polymer-assisted solution phase synthesis of the antihyperglycemic agent Rosiglitazone (Avandia). , 2003, Organic & biomolecular chemistry.

[56]  J. Baldwin,et al.  Biomimetic studies on polyenes. , 2003, Organic & biomolecular chemistry.

[57]  D. Williams.  A chemist's view of the nitric oxide story. , 2003, Organic & biomolecular chemistry.

[58]  W. Goldring,et al.  A total synthesis of phomactin A. , 2003, Chemical communications.

[59]  O. Seitz,et al.  New isocysteine building blocks and chemoselective peptide ligation. , 2004, Organic & biomolecular chemistry.

[60]  J. Becher,et al.  New strategies and building blocks for functionalised 9,10-bis(1,3-dithiol-2-ylidene)-9,10-dihydroanthracene derivatives, including pyrrolo-annelated derivatives and pi-extended systems with intramolecular charge-transfer. , 2003, Organic & biomolecular chemistry.

[61]  Scope of the reductive aldol reaction: application to aromatic carbocycles and heterocycles. , 2003, Organic & biomolecular chemistry.

[62]  Simon M. Tyrrell,et al.  Representation and use of chemistry in the global electronic age. , 2004, Organic & biomolecular chemistry.

[63]  L. Amos,et al.  Microtubule structure and its stabilisation. , 2004, Organic & biomolecular chemistry.

[64]  David R Spring,et al.  Diversity-oriented synthesis; a challenge for synthetic chemists. , 2003, Organic & biomolecular chemistry.

[65]  Koji Nakanishi,et al.  A2-rhodopsin: a new fluorophore isolated from photoreceptor outer segments. , 2003, Organic and biomolecular chemistry.

[66]  J. Michael.  Quinoline, quinazoline and acridone alkaloids. , 2001, Natural product reports.

[67]  J. Trent,et al.  Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives. , 2003, Organic & biomolecular chemistry.

[68]  D. Armstrong,et al.  Assignment of absolute configuration of a chiral phenyl-substituted dihydrofuroangelicin. , 2003, Organic & biomolecular chemistry.

[69]  B. Plietker,et al.  The RuO4-catalysed dihydroxylation, ketohydroxylation and mono oxidation--novel oxidation reactions for the synthesis of diols and alpha-hydroxy ketones. , 2004, Organic & biomolecular chemistry.

[70]  Shuj Kobayashi,et al.  Hydrophobic, low-loading and alkylated polystyrene-supported sulfonic acid for several organic reactions in water: remarkable effects of both the polymer structures and loading levels of sulfonic acids. , 2003, Organic & biomolecular chemistry.

[71]  H. Schoemaker,et al.  A pincer auxiliary to force difficult lactamisations. , 2003, Organic & biomolecular chemistry.

[72]  R. Glen,et al.  Molecular similarity: a key technique in molecular informatics. , 2004, Organic & biomolecular chemistry.

[73]  L. Overman,et al.  The tethered Biginelli condensation in natural product synthesis. , 2004, Chemical communications.

[74]  H. Miyabe,et al.  The utility of indium in aqueous medium radical reactions. , 2004, Organic & biomolecular chemistry.

[75]  Jieping Zhu,et al.  From central to planar chirality, the first example of atropenantioselective cycloetherification. , 2003, Organic & biomolecular chemistry.

[76]  J. Chattopadhyaya,et al.  Antisense oligonuclotides with oxetane-constrained cytidine enhance heteroduplex stability, and elicit satisfactory RNase H response as well as showing improved resistance to both exo and endonucleases. , 2003, Organic & biomolecular chemistry.

[77]  S. Withers,et al.  Nature's many mechanisms for the degradation of oligosaccharides. , 2004, Organic & biomolecular chemistry.

[78]  J. Clayden.  Atropisomers and near-atropisomers: achieving stereoselectivity by exploiting the conformational preferences of aromatic amides. , 2004, Chemical communications.

[79]  B. K. Carpenter.  Understanding the puzzling chemistry of bicyclo[2.1.0]pentane. , 2004, Organic & biomolecular chemistry.

[80]  Andrew G. Leach,et al.  The mechanism and regioselectivity of the ene reactions of nitroso compounds: a theoretical study of reactivity, regioselectivity, and kinetic isotope effects establishes a stepwise path involving polarized diradical intermediates. , 2003, Organic & biomolecular chemistry.

[81]  S. Withers,et al.  Mechanistic analogies amongst carbohydrate modifying enzymes. , 2004, Chemical communications.

[82]  U. Hanefeld.  Reagents for (ir)reversible enzymatic acylations. , 2003, Organic & biomolecular chemistry.

[83]  D. Reinhoudt,et al.  Multivalency in supramolecular chemistry and nanofabrication. , 2004, Organic & biomolecular chemistry.

[84]  K. Altmann.  The merger of natural product synthesis and medicinal chemistry: on the chemistry and chemical biology of epothilones. , 2004, Organic & biomolecular chemistry.

[85]  B. Imperiali,et al.  Peptides to peptidomimetics: towards the design and synthesis of bioavailable inhibitors of oligosaccharyl transferase. , 2003, Organic & biomolecular chemistry.

[86]  Claus Jacob,et al.  The sulfinic acid switch in proteins , 2004 .

[87]  R. Evans,et al.  Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. , 2003, Organic & biomolecular chemistry.

[88]  Substituted tren-capped porphyrins: probing the influence of copper in synthetic models of cytochrome c oxidase. , 2003, Organic & biomolecular chemistry.

[89]  V. Aggarwal,et al.  The use of enantiomerically pure ketene dithioacetal bis(sulfoxides) in highly diastereoselective intramolecular nitrone cycloadditions. Application in the total synthesis of the beta-amino acid (-)-cispentacin and the first asymmetric synthesis of cis-(3R,4R)-4-amino-pyrrolidine-3-carboxylic acid. , 2003, Organic & biomolecular chemistry.

[90]  Y. Yamaguchi,et al.  Detection of a metallo-beta-lactamase (IMP-1) by fluorescent probes having dansyl and thiol groups. , 2003, Organic & biomolecular chemistry.

[91]  V. Aggarwal,et al.  The complexity of catalysis: origins of enantio- and diastereocontrol in sulfur ylide mediated epoxidation reactions. , 2003, Chemical communications.

[92]  O. Kent,et al.  RNAi: running interference for the cell. , 2004, Organic & biomolecular chemistry.

[93]  E. Unanue,et al.  Influence of saccharide size on the cellular immune response to glycopeptides. , 2003, Organic & biomolecular chemistry.

[94]  J. M. Sanderson,et al.  The synthesis of peptides and proteins containing non-natural amino acids. , 2004, Chemical Society reviews.

[95]  Peter Murray-Rust,et al.  Experimental data checker: better information for organic chemists. , 2004, Organic & biomolecular chemistry.

[96]  S. Ley,et al.  A concise total synthesis of (+)-okaramine C. , 2004, Organic & biomolecular chemistry.

[97]  J. Stubbe,et al.  Polyhydroxyalkanoate (PHA) homeostasis: the role of the PHA synthase , 2003 .

[98]  M. Ladlow,et al.  The development and preparation of the 2,4-dimethoxybenzyl arylhydrazine (DMBAH) "latent" safety-catch linker: solid phase synthesis of ketopiperazines. , 2003, Organic & biomolecular chemistry.

[99]  K. Laali,et al.  A theoretical (DFT, GIAO-NMR, NICS) study of the carbocations and oxidation dications from azulenes, homoazulene, benzazulenes, benzohomoazulenes, and the isomeric azulenoazulenes. , 2003, Organic & biomolecular chemistry.

[100]  E. Buncel,et al.  High Brønsted βnuc values in SNAr displacement. An indicator of the SET pathway , 2003 .

[101]  H. Zipse.  The influence of hydrogen bonding interactions on the C-H bond activation step in class I ribonucleotide reductases. , 2003, Organic & biomolecular chemistry.

[102]  C. Moody.  Addition reactions of ROPHy/SOPHy oxime ethers: asymmetric synthesis of nitrogen containing compounds. , 2004, Chemical communications.

[103]  M. Inoue.  Convergent syntheses of polycyclic ethers. Illustrations of the utility of acetal-linked intermediates. , 2004, Organic & biomolecular chemistry.

[104]  E. Nakamura,et al.  Regioselective synthesis of [60]fullerene η5-indenide R3C60− and η5-cyclopentadienide R5C60− bearing different R groups , 2003 .

[105]  M. Searle,et al.  DNA recognition by the anthracycline antibiotic respinomycin D: NMR structure of the intercalation complex with d(AGACGTCT)2. , 2003, Organic & biomolecular chemistry.

[106]  C. Nielsen,et al.  Synthesis and evaluation of new potential HIV-1 non-nucleoside reverse transcriptase inhibitors. New analogues of MKC-442 containing Michael acceptors in the C-6 position. , 2003, Organic & biomolecular chemistry.

[107]  F. Seela,et al.  Oligonucleotide duplexes containing N8-glycosylated 8-aza-7-deazaguanine and self-assembly of 8-aza-7-deazapurines on the nucleoside and the oligomeric level. , 2003, Organic & biomolecular chemistry.

[108]  Helen E Blackwell,et al.  Out of the oil bath and into the oven--microwave-assisted combinatorial chemistry heats up. , 2003, Organic & biomolecular chemistry.

[109]  G. Lloyd‐Jones.  Mechanistic aspects of transition metal catalysed 1,6-diene and 1,6-enyne cycloisomerisation reactions. , 2003, Organic & biomolecular chemistry.

[110]  P. Nielsen,et al.  Bicyclic nucleosides; stereoselective dihydroxylation and 2'-deoxygenation. , 2003, Organic & biomolecular chemistry.

[111]  Peter H Seeberger,et al.  Automated carbohydrate synthesis to drive chemical glycomics. , 2003, Chemical communications.

[112]  R. Weatherman.  Chemical approaches to studying transcription. , 2003, Organic & biomolecular chemistry.

[113]  R. Ulijn,et al.  Enzymatic optical resolution via acylation-hydrolysis on a solid support. , 2003, Organic & biomolecular chemistry.

[114]  R. Austin,et al.  Structure–reactivity relationships in the inactivation of elastase by β-sultams , 2003 .

[115]  S. Ley,et al.  Development of beta-keto 1,3-dithianes as versatile intermediates for organic synthesis. , 2003, Organic & biomolecular chemistry.

[116]  Linda C Hsieh-Wilson,et al.  A 'molecular switchboard'--covalent modifications to proteins and their impact on transcription. , 2004, Organic & biomolecular chemistry.

[117]  S. Davies,et al.  SuperQuat N-acyl-5,5-dimethyloxazolidin-2-ones for the asymmetric synthesis of α-alkyl and β-alkyl aldehydes , 2003 .

[118]  Bradley D. Smith,et al.  Facilitated phosphatidylserine flip-flop across vesicle and cell membranes using urea-derived synthetic translocases. , 2004, Organic & biomolecular chemistry.

[119]  R. J. Williams,et al.  Metallo-enzyme catalysis. , 2003, Chemical communications.

[120]  Bradley D. Smith,et al.  Facilitated transport of sodium or potassium chloride across vesicle membranes using a ditopic salt-binding macrobicycle. , 2003, Organic & biomolecular chemistry.

[121]  Auke Meetsma,et al.  A donor-acceptor substituted molecular motor: unidirectional rotation driven by visible light. , 2003, Organic & biomolecular chemistry.