Autistic college students face significant challenges in college settings and have a higher dropout rate than neurotypical college students. High physiological distress, depression, and anxiety are identified as critical challenges that contribute to this less than optimal college experience. In this paper, we leverage affordable mobile and wearable devices to collect large amounts of physiological and contextual data (biomarkers) and leverage a data-driven analysis approach for building stress prediction models. Such models can be used to provide real-time intervention for better stress management. We conducted a mixed-method study where we collected physiological and contextual data from 20 college students (10 neurotypical and 10 autistic). Our proposed data-driven analysis pipeline leverages an unsupervised representation learning technique with a semi-supervised label approximation method to predict the onset of stress based on biomarkers for autistic students, neurotypical students, and both populations with accuracies 69%, 72%, and 70%, respectively.